NO310498B1 - Fremgangsmåte for fremstilling av et immunstimuleringsmiddel - Google Patents
Fremgangsmåte for fremstilling av et immunstimuleringsmiddel Download PDFInfo
- Publication number
- NO310498B1 NO310498B1 NO19905228A NO905228A NO310498B1 NO 310498 B1 NO310498 B1 NO 310498B1 NO 19905228 A NO19905228 A NO 19905228A NO 905228 A NO905228 A NO 905228A NO 310498 B1 NO310498 B1 NO 310498B1
- Authority
- NO
- Norway
- Prior art keywords
- lysozyme
- immunostimulant
- bulgaricus
- culture
- milk
- Prior art date
Links
- 230000003308 immunostimulating effect Effects 0.000 title claims abstract description 33
- 239000003022 immunostimulating agent Substances 0.000 title claims abstract description 29
- 229960001438 immunostimulant agent Drugs 0.000 title claims abstract description 27
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 102000016943 Muramidase Human genes 0.000 claims abstract description 53
- 108010014251 Muramidase Proteins 0.000 claims abstract description 53
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 53
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 53
- 229960000274 lysozyme Drugs 0.000 claims abstract description 53
- 239000004325 lysozyme Substances 0.000 claims abstract description 53
- 241000894006 Bacteria Species 0.000 claims abstract description 18
- 235000013336 milk Nutrition 0.000 claims abstract description 18
- 239000008267 milk Substances 0.000 claims abstract description 18
- 210000004080 milk Anatomy 0.000 claims abstract description 18
- 210000002421 cell wall Anatomy 0.000 claims abstract description 12
- 241000186672 Lactobacillus delbrueckii subsp. bulgaricus Species 0.000 claims abstract 5
- 210000004027 cell Anatomy 0.000 claims description 25
- 235000013351 cheese Nutrition 0.000 claims description 21
- -1 N -acetylmuramyl Chemical group 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 230000007062 hydrolysis Effects 0.000 claims description 12
- 238000006460 hydrolysis reaction Methods 0.000 claims description 12
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 11
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000001963 growth medium Substances 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 7
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 6
- 102000002322 Egg Proteins Human genes 0.000 claims description 6
- 108010000912 Egg Proteins Proteins 0.000 claims description 6
- 235000014103 egg white Nutrition 0.000 claims description 6
- 210000000969 egg white Anatomy 0.000 claims description 6
- 238000011218 seed culture Methods 0.000 claims description 6
- 235000020247 cow milk Nutrition 0.000 claims description 5
- 235000014048 cultured milk product Nutrition 0.000 claims description 3
- 238000011081 inoculation Methods 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 16
- 239000005862 Whey Substances 0.000 abstract description 12
- 102000007544 Whey Proteins Human genes 0.000 abstract description 12
- 108010046377 Whey Proteins Proteins 0.000 abstract description 12
- 239000000725 suspension Substances 0.000 abstract description 10
- 235000015140 cultured milk Nutrition 0.000 abstract description 7
- 239000006228 supernatant Substances 0.000 abstract description 4
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 28
- 241000699670 Mus sp. Species 0.000 description 22
- 229960005486 vaccine Drugs 0.000 description 9
- 235000013618 yogurt Nutrition 0.000 description 9
- 238000012360 testing method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 238000002627 tracheal intubation Methods 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- 241000194020 Streptococcus thermophilus Species 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000002028 Biomass Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 244000197960 Galium verum Species 0.000 description 3
- 235000000911 Galium verum Nutrition 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000006872 mrs medium Substances 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000369 enteropathogenic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940108461 rennet Drugs 0.000 description 1
- 108010058314 rennet Proteins 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/335—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dairy Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4484/89A CH680192A5 (ko) | 1989-12-13 | 1989-12-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO905228D0 NO905228D0 (no) | 1990-12-03 |
| NO905228L NO905228L (no) | 1991-06-14 |
| NO310498B1 true NO310498B1 (no) | 2001-07-16 |
Family
ID=4276966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19905228A NO310498B1 (no) | 1989-12-13 | 1990-12-03 | Fremgangsmåte for fremstilling av et immunstimuleringsmiddel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5185321A (ko) |
| EP (1) | EP0432490B2 (ko) |
| JP (1) | JP2595133B2 (ko) |
| AT (1) | ATE127023T1 (ko) |
| AU (1) | AU643728B2 (ko) |
| CA (1) | CA2030951C (ko) |
| CH (1) | CH680192A5 (ko) |
| DE (1) | DE69022005T3 (ko) |
| DK (1) | DK0432490T4 (ko) |
| ES (1) | ES2076280T5 (ko) |
| GR (1) | GR3017428T3 (ko) |
| IE (1) | IE68244B1 (ko) |
| MX (1) | MX172984B (ko) |
| NO (1) | NO310498B1 (ko) |
| NZ (1) | NZ236295A (ko) |
| PT (1) | PT96167B (ko) |
| ZA (1) | ZA909658B (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0686039B1 (en) * | 1993-02-24 | 2000-08-23 | Valio Ltd. | Method of enhancing immune response to oral vaccines |
| WO1994022459A1 (en) * | 1993-04-07 | 1994-10-13 | Eisai Co., Ltd. | Immunopotentiative and infection-protective agent, containing two or more bacillus, egg white and garlic |
| US6348346B1 (en) | 1994-05-27 | 2002-02-19 | University Of Kentucky Research Foundation | Method of inhibiting binding activity of immunoglobulins |
| DE19619505C2 (de) * | 1996-05-14 | 1998-03-26 | Zyma Gmbh | Milch/Bakterienlysat zur Herstellung von Kosmetika und Arzneimitteln |
| GB9822619D0 (en) * | 1998-10-19 | 1998-12-09 | Porter William L | Immune response stimulation |
| US6696057B1 (en) | 1999-09-22 | 2004-02-24 | Lacpro Industries, Inc. | Composition and method for treatment of gastrointestinal disorders and hyperlipidemia |
| US20040166101A1 (en) * | 1999-09-22 | 2004-08-26 | Bojrab Gregory G. | Enchanced composition for treatment of gastrointestinal disorders and hyperlipidemia |
| US6641808B1 (en) * | 1999-09-22 | 2003-11-04 | Lacpro Industries, Llc | Composition for treatment of obesity |
| US6827940B1 (en) | 2000-05-25 | 2004-12-07 | Aidan Products, Llc | Immune-stimulating bacterial cell wall extracts |
| EP1303300B1 (en) * | 2000-06-19 | 2010-08-11 | Hunter Immunology Limited | Compositions and methods for treatment of candidiasis |
| GB0027761D0 (en) * | 2000-11-14 | 2000-12-27 | Nestle Sa | Nutritional composition for an immune condition |
| US20040258779A1 (en) * | 2003-06-06 | 2004-12-23 | Pinegrin Boris V. | Dietary and pharmaceutical compositions for treatment of anemia, thrombocytopenia, and leukopenia |
| JP4716769B2 (ja) * | 2005-03-29 | 2011-07-06 | キユーピー株式会社 | 血圧降下剤の製造方法 |
| JP4716770B2 (ja) * | 2005-03-29 | 2011-07-06 | キユーピー株式会社 | 免疫賦活・アレルギー改善剤の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO134752C (ko) * | 1965-06-01 | 1976-12-08 | Texim Entreprise Economique D | |
| SU618088A1 (ru) * | 1975-06-03 | 1978-08-05 | Киргизский Научно-Исследовательский Институт Акушерства И Педиатрии | Способ получени детского лечебного кисломолочного продукта |
| FR2343484A1 (fr) * | 1976-03-10 | 1977-10-07 | Anvar | Le 2- (2-acetamido-2-deoxy-3-o-d-glucopyranosyl) -d-propionyl-l-alanyl-d- (a-methylamide)-glutamique et medicaments le contenant |
| SU789096A1 (ru) * | 1978-03-23 | 1980-12-23 | Киргизский Научно-Исследовательский Институт Акушерства И Педиатрии | Способ получени кисломолочного продукта дл детского питани |
| JPS5553298A (en) * | 1978-10-17 | 1980-04-18 | Dainippon Pharmaceut Co Ltd | Water-soluble peptide glycan |
| FR2454302A1 (fr) * | 1979-04-18 | 1980-11-14 | Rhone Poulenc Ind | Nouvelle substance biologiquement active, sa preparation et les medicaments qui la contiennent |
| JPS58126797A (ja) * | 1982-01-22 | 1983-07-28 | Dainippon Pharmaceut Co Ltd | ジサツカライドトリペプチド及びジサツカライドテトラペプチドの製法 |
| FR2523154A1 (fr) * | 1982-03-09 | 1983-09-16 | Fabre Sa Pierre | Procede de preparation de proteoglycanes immunostimulants inducteurs d'interferon, proteoglycanes obtenus et medicaments les contenant |
| SU1465003A1 (ru) † | 1987-06-25 | 1989-03-15 | Всесоюзный научно-исследовательский и конструкторский институт молочной промышленности | Способ производства адаптированного кисломолочного продукта дл детского питани |
-
1989
- 1989-12-13 CH CH4484/89A patent/CH680192A5/fr not_active IP Right Cessation
-
1990
- 1990-11-14 ES ES90121752T patent/ES2076280T5/es not_active Expired - Lifetime
- 1990-11-14 DE DE69022005T patent/DE69022005T3/de not_active Expired - Lifetime
- 1990-11-14 DK DK90121752T patent/DK0432490T4/da not_active Application Discontinuation
- 1990-11-14 AT AT90121752T patent/ATE127023T1/de not_active IP Right Cessation
- 1990-11-14 EP EP90121752A patent/EP0432490B2/fr not_active Expired - Lifetime
- 1990-11-27 AU AU67021/90A patent/AU643728B2/en not_active Expired
- 1990-11-27 CA CA002030951A patent/CA2030951C/en not_active Expired - Lifetime
- 1990-11-27 US US07/619,119 patent/US5185321A/en not_active Expired - Lifetime
- 1990-11-30 NZ NZ236295A patent/NZ236295A/en unknown
- 1990-11-30 ZA ZA909658A patent/ZA909658B/xx unknown
- 1990-11-30 IE IE432390A patent/IE68244B1/en not_active IP Right Cessation
- 1990-12-03 NO NO19905228A patent/NO310498B1/no not_active IP Right Cessation
- 1990-12-11 MX MX023693A patent/MX172984B/es unknown
- 1990-12-12 PT PT96167A patent/PT96167B/pt not_active IP Right Cessation
- 1990-12-13 JP JP2402041A patent/JP2595133B2/ja not_active Expired - Lifetime
-
1995
- 1995-09-18 GR GR950402553T patent/GR3017428T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ236295A (en) | 1993-04-28 |
| DE69022005T3 (de) | 2001-10-04 |
| CA2030951A1 (en) | 1991-06-14 |
| CH680192A5 (ko) | 1992-07-15 |
| DE69022005T2 (de) | 1996-02-15 |
| JPH03255034A (ja) | 1991-11-13 |
| CA2030951C (en) | 2002-01-15 |
| IE904323A1 (en) | 1991-06-19 |
| EP0432490A2 (fr) | 1991-06-19 |
| DE69022005D1 (de) | 1995-10-05 |
| JP2595133B2 (ja) | 1997-03-26 |
| ZA909658B (en) | 1991-09-25 |
| EP0432490A3 (en) | 1991-08-21 |
| NO905228D0 (no) | 1990-12-03 |
| MX172984B (es) | 1994-01-26 |
| PT96167B (pt) | 2001-05-31 |
| US5185321A (en) | 1993-02-09 |
| NO905228L (no) | 1991-06-14 |
| IE68244B1 (en) | 1996-06-12 |
| ATE127023T1 (de) | 1995-09-15 |
| AU6702190A (en) | 1991-06-20 |
| ES2076280T5 (es) | 2001-09-01 |
| EP0432490B2 (fr) | 2001-05-16 |
| GR3017428T3 (en) | 1995-12-31 |
| ES2076280T3 (es) | 1995-11-01 |
| DK0432490T3 (da) | 1995-12-27 |
| AU643728B2 (en) | 1993-11-25 |
| EP0432490B1 (fr) | 1995-08-30 |
| DK0432490T4 (da) | 2001-08-06 |
| PT96167A (pt) | 1991-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JUNE 2003 |