NO309173B1 - Virkestoffholdig transdermalt farmasöytisk preparat (plaster) for anvendelse på huden samt fremgangsmåte for dets fremstilling - Google Patents
Virkestoffholdig transdermalt farmasöytisk preparat (plaster) for anvendelse på huden samt fremgangsmåte for dets fremstilling Download PDFInfo
- Publication number
- NO309173B1 NO309173B1 NO982621A NO982621A NO309173B1 NO 309173 B1 NO309173 B1 NO 309173B1 NO 982621 A NO982621 A NO 982621A NO 982621 A NO982621 A NO 982621A NO 309173 B1 NO309173 B1 NO 309173B1
- Authority
- NO
- Norway
- Prior art keywords
- active ingredient
- pharmaceutical preparation
- preparation according
- layer
- pharmaceutical
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title description 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 claims abstract description 28
- 239000012790 adhesive layer Substances 0.000 claims abstract description 14
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 14
- 239000000853 adhesive Substances 0.000 claims abstract description 9
- 230000001070 adhesive effect Effects 0.000 claims abstract description 6
- 239000010410 layer Substances 0.000 claims description 50
- 239000004480 active ingredient Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 239000003435 antirheumatic agent Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000011241 protective layer Substances 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003270 steroid hormone Substances 0.000 claims description 2
- 230000003937 effect on alzheimer disease Effects 0.000 claims 1
- 239000011888 foil Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 229920000728 polyester Polymers 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229920004939 Cariflex™ Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- -1 glycerol ester Chemical class 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19546024A DE19546024C2 (de) | 1995-12-09 | 1995-12-09 | Transdermale pharmazeutische Zubereitung und deren Herstellung |
| PCT/EP1996/005411 WO1997021430A2 (de) | 1995-12-09 | 1996-12-04 | Flächenstabilisierte pharmazeutische zubereitung zur anwendung auf der haut |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982621D0 NO982621D0 (no) | 1998-06-08 |
| NO982621L NO982621L (no) | 1998-06-08 |
| NO309173B1 true NO309173B1 (no) | 2000-12-27 |
Family
ID=7779685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982621A NO309173B1 (no) | 1995-12-09 | 1998-06-08 | Virkestoffholdig transdermalt farmasöytisk preparat (plaster) for anvendelse på huden samt fremgangsmåte for dets fremstilling |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6207183B1 (hu) |
| EP (1) | EP0865274B1 (hu) |
| JP (1) | JP3525391B2 (hu) |
| KR (1) | KR100444541B1 (hu) |
| AT (1) | ATE185069T1 (hu) |
| AU (1) | AU715763B2 (hu) |
| CA (1) | CA2239952C (hu) |
| CZ (1) | CZ289240B6 (hu) |
| DE (2) | DE19546024C2 (hu) |
| DK (1) | DK0865274T3 (hu) |
| ES (1) | ES2141548T3 (hu) |
| GR (1) | GR3032219T3 (hu) |
| HU (1) | HUP9904181A3 (hu) |
| IL (1) | IL124538A (hu) |
| MY (1) | MY132532A (hu) |
| NO (1) | NO309173B1 (hu) |
| NZ (1) | NZ324306A (hu) |
| PL (1) | PL327321A1 (hu) |
| SI (1) | SI0865274T1 (hu) |
| SK (1) | SK281406B6 (hu) |
| WO (1) | WO1997021430A2 (hu) |
| ZA (1) | ZA9610270B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100382373B1 (ko) * | 2000-08-28 | 2003-05-01 | 주식회사 동성화학 | 약제의 역확산 억제능이 우수한 패취제 제조용 폴리우레탄 지지체 및 이의 제조방법 |
| US20040043171A1 (en) | 2002-08-30 | 2004-03-04 | Audett Jay Douglas | Multilaminate backing construction |
| DE10356925B4 (de) * | 2003-12-05 | 2006-05-11 | Lts Lohmann Therapie-Systeme Ag | Inhalator für basische pharmazeutische Wirkstoffe sowie Verfahren für dessen Herstellung |
| DE102004039728A1 (de) * | 2004-08-16 | 2006-02-23 | Beiersdorf Ag | Wirkstoffhaltiges Tape zur Behandlung von Gelenkerkrankungen |
| US9155725B2 (en) * | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
| EP2255809B1 (en) * | 2008-02-27 | 2017-08-23 | Hisamitsu Pharmaceutical Co., Inc. | Medicated patch |
| EP2111857A1 (de) * | 2008-04-25 | 2009-10-28 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4725439A (en) * | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| DE68917292T2 (de) | 1988-02-26 | 1995-02-02 | Riker Laboratories Inc | Transdermales estradiol als therapeutisches sytem. |
| US4994278A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Breathable backing |
| GB8812096D0 (en) * | 1988-05-21 | 1988-06-22 | Smith & Nephew Ass | Adhesive sheet |
| US4859935A (en) | 1988-10-27 | 1989-08-22 | Tektronix, Inc. | Method and apparatus for combining an optical and electrical channel in an oscilloscope |
| AU9147691A (en) * | 1990-11-28 | 1992-06-25 | Sano Corporation | Method and device for treating tobacco addiction |
| US5352456A (en) * | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| US5246705A (en) * | 1992-04-08 | 1993-09-21 | Cygnus Therapeutic System | Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use |
| DE4341444C2 (de) * | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
| US5536263A (en) * | 1994-03-30 | 1996-07-16 | Lectec Corporation | Non-occulusive adhesive patch for applying medication to the skin |
-
1995
- 1995-12-09 DE DE19546024A patent/DE19546024C2/de not_active Expired - Fee Related
-
1996
- 1996-12-04 JP JP52170397A patent/JP3525391B2/ja not_active Expired - Fee Related
- 1996-12-04 SI SI9630131T patent/SI0865274T1/xx unknown
- 1996-12-04 NZ NZ324306A patent/NZ324306A/en unknown
- 1996-12-04 EP EP96942341A patent/EP0865274B1/de not_active Expired - Lifetime
- 1996-12-04 ES ES96942341T patent/ES2141548T3/es not_active Expired - Lifetime
- 1996-12-04 CZ CZ19981711A patent/CZ289240B6/cs not_active IP Right Cessation
- 1996-12-04 AT AT96942341T patent/ATE185069T1/de active
- 1996-12-04 DE DE59603246T patent/DE59603246D1/de not_active Expired - Lifetime
- 1996-12-04 PL PL96327321A patent/PL327321A1/xx unknown
- 1996-12-04 HU HU9904181A patent/HUP9904181A3/hu unknown
- 1996-12-04 IL IL12453896A patent/IL124538A/xx not_active IP Right Cessation
- 1996-12-04 WO PCT/EP1996/005411 patent/WO1997021430A2/de active IP Right Grant
- 1996-12-04 DK DK96942341T patent/DK0865274T3/da active
- 1996-12-04 AU AU11764/97A patent/AU715763B2/en not_active Ceased
- 1996-12-04 CA CA002239952A patent/CA2239952C/en not_active Expired - Fee Related
- 1996-12-04 SK SK674-98A patent/SK281406B6/sk unknown
- 1996-12-04 KR KR10-1998-0704155A patent/KR100444541B1/ko not_active IP Right Cessation
- 1996-12-04 US US09/091,259 patent/US6207183B1/en not_active Expired - Fee Related
- 1996-12-06 ZA ZA9610270A patent/ZA9610270B/xx unknown
- 1996-12-06 MY MYPI96005139A patent/MY132532A/en unknown
-
1998
- 1998-06-08 NO NO982621A patent/NO309173B1/no not_active IP Right Cessation
-
1999
- 1999-12-22 GR GR990403306T patent/GR3032219T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100343877B1 (ko) | 에스트라디올을함유하는경피치료시스템 | |
| JP3228341B2 (ja) | 塩基性薬物を経皮的に送達するための透過増強剤としてのトリアセチン | |
| JP2701951B2 (ja) | プリントされた皮膚透過性薬剤投与具 | |
| JP3523259B2 (ja) | 溶媒なしに製造できる揮発性活性物質を含有するプラスター | |
| KR101396446B1 (ko) | 첩부제 | |
| TWI244395B (en) | Pressure-sensitive adhesive transdermal drug delivery system containing low molecular weight drugs which are liquid at room temperatures, and method of providing the same | |
| JPH0575727B2 (hu) | ||
| NO333297B1 (no) | Forbedret transdermalt leveringssystem for administrering av rotigotin | |
| WO2005105150A1 (ja) | 貼付剤 | |
| JPH11512080A (ja) | 皮膚を通して人体に活性物質を供給するための経皮性治療システム | |
| JP2004529890A (ja) | 活性成分としてのニコチンを有する可撓性の著しい皮膚透過性治療系 | |
| NO309173B1 (no) | Virkestoffholdig transdermalt farmasöytisk preparat (plaster) for anvendelse på huden samt fremgangsmåte for dets fremstilling | |
| JPWO2017164084A1 (ja) | 誤用防止特性を有する貼付製剤 | |
| AU725245B2 (en) | Extensible transdermal therapeutic system | |
| JP3248764B2 (ja) | 貼付剤 | |
| JP2781016B2 (ja) | 経皮吸収製剤 | |
| JPH09509154A (ja) | 活性物質モルフィン−６−グルクロニドを含む全身的経皮投与用医薬組成物 | |
| JP6912122B2 (ja) | 経皮投与製剤 | |
| KR19980701419A (ko) | (s)-3-메틸-5-(1-메틸-2-피롤리데닐)-이속사졸 또는 약제학적으로 허용가능한 이의 염들 중 하나를 투여하기 위한 트랜스더멀 치료 시스템 | |
| JP2003505411A (ja) | カルシウムアンタゴニストを投与するための経皮治療系 | |
| JPH08291055A (ja) | 形状記憶貼付剤 | |
| CN117797125A (zh) | 含有秋水仙碱的贴剂及其制备方法和应用 | |
| MXPA98004617A (en) | Pharmaceutical preparation stabilized on the surface to be applied on the p | |
| CN1204257A (zh) | 用于皮肤的表面稳定药物制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JUNE 2002 |