NO306901B1 - Piperazinderivater, anvendelser derav, samt farmasöytiske preparater omfattende slike derivater - Google Patents
Piperazinderivater, anvendelser derav, samt farmasöytiske preparater omfattende slike derivaterInfo
- Publication number
- NO306901B1 NO306901B1 NO941802A NO941802A NO306901B1 NO 306901 B1 NO306901 B1 NO 306901B1 NO 941802 A NO941802 A NO 941802A NO 941802 A NO941802 A NO 941802A NO 306901 B1 NO306901 B1 NO 306901B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- aryl
- derivatives
- alkylene
- Prior art date
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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- Diabetes (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11277193 | 1993-05-14 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO941802D0 NO941802D0 (no) | 1994-05-13 |
NO941802L NO941802L (no) | 1994-11-15 |
NO306901B1 true NO306901B1 (no) | 2000-01-10 |
Family
ID=14595104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO941802A NO306901B1 (no) | 1993-05-14 | 1994-05-13 | Piperazinderivater, anvendelser derav, samt farmasöytiske preparater omfattende slike derivater |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0624584B1 (da) |
JP (2) | JP3220591B2 (da) |
KR (1) | KR100303737B1 (da) |
CN (1) | CN1049654C (da) |
AT (1) | ATE169914T1 (da) |
AU (2) | AU677644B2 (da) |
CA (1) | CA2123548C (da) |
DE (1) | DE69412534T2 (da) |
DK (1) | DK0624584T3 (da) |
EE (1) | EE03139B1 (da) |
ES (1) | ES2125372T3 (da) |
FI (1) | FI942252A (da) |
GR (1) | GR3027679T3 (da) |
HK (1) | HK1002221A1 (da) |
NO (1) | NO306901B1 (da) |
RU (1) | RU2124511C1 (da) |
SG (1) | SG48920A1 (da) |
SI (1) | SI0624584T1 (da) |
TW (1) | TW418198B (da) |
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JP3948744B2 (ja) * | 1994-11-04 | 2007-07-25 | 大日本住友製薬株式会社 | 新規なラクタム誘導体 |
CN1067998C (zh) * | 1994-11-14 | 2001-07-04 | 第一制药株式会社 | 药用水合物 |
CA2180190A1 (en) * | 1995-07-10 | 1997-01-11 | Kazumi Ogata | Benzylpiperazine derivatives |
WO1997041108A1 (en) * | 1996-04-30 | 1997-11-06 | Warner-Lambert Company | Substituted piperazines and piperidines as central nervous system agents |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
US5859246A (en) * | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
KR20010040254A (ko) * | 1997-09-29 | 2001-05-15 | 스티븐 엘. 네스빗 | 아미노알킬페놀 유도체 및 관련 화합물 |
US6479495B1 (en) * | 1997-09-29 | 2002-11-12 | Aventis Pharmaceuticals Inc. | Aminoalkylphenol derivatives and related compounds |
US6596706B1 (en) * | 1997-11-07 | 2003-07-22 | Daiichi Pharmaceutical Co., Ltd. | Piperazine-cyclodextrin complexes |
AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
DE19934432A1 (de) | 1999-07-22 | 2001-02-01 | Merck Patent Gmbh | Indolderivate |
CA2414198A1 (en) | 2000-07-06 | 2002-01-17 | Neurogen Corporation | Melanin concentrating hormone receptor ligands |
MY140070A (en) | 2001-05-18 | 2009-11-30 | Astrazeneca Ab | 4-(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
MXPA03010612A (es) | 2001-05-22 | 2004-04-02 | Neurogen Corp | Ligandos receptores de la hormona concentradora de melanina: analogos de 1-bencil-4-aril piperazina substiruidos. |
CN1150176C (zh) * | 2002-05-22 | 2004-05-19 | 上海医药工业研究院 | 芳烷酮哌嗪衍生物及其应用 |
CN100558718C (zh) | 2002-10-23 | 2009-11-11 | 詹森药业有限公司 | 哌嗪基和二氮杂环庚基苯甲酰胺和硫代苯甲酰胺 |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
KR100774621B1 (ko) | 2003-09-09 | 2007-11-14 | 에프. 호프만-라 로슈 아게 | 정신병 치료용의 글라이신 섭취 억제제로서의1-벤조일-피페라진 유도체 |
US7253168B2 (en) | 2004-04-07 | 2007-08-07 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
BRPI0511834A (pt) | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | métodos por tratar hepatite c |
NZ553329A (en) | 2004-07-22 | 2010-09-30 | Ptc Therapeutics Inc | Thienopyridines for treating hepatitis C |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
CA2581454A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyrimidine compounds, process for their preparation and compositions containing them |
DE602005014274D1 (de) | 2004-12-09 | 2009-06-10 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
ES2338139T3 (es) | 2004-12-15 | 2010-05-04 | F. Hoffmann-La Roche Ag | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
DE602005022113D1 (de) | 2005-01-07 | 2010-08-12 | Hoffmann La Roche | Phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen |
KR100915472B1 (ko) | 2005-01-26 | 2009-09-03 | 에프. 호프만-라 로슈 아게 | 페닐 메탄온 유도체 및 그의 글라이신 트랜스포터 1억제제로서의 용도 |
ES2334578T3 (es) | 2005-02-07 | 2010-03-12 | F. Hoffmann-La Roche Ag | Fenil-metanonas sustituidas por heterociclo como inhibidores del transportador 1 de la glicina. |
JP2009509921A (ja) * | 2005-08-12 | 2009-03-12 | アストラゼネカ アクチボラグ | 置換イソインドロン類及び代謝調節型グルタミン酸受容体増強剤としてのその使用 |
US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
US8003624B2 (en) * | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
WO2007035425A2 (en) | 2005-09-16 | 2007-03-29 | Janssen Pharmaceutica N.V. | Cyclopropyl amines as modulators of the histamine h3 receptor |
JP4783154B2 (ja) | 2006-01-11 | 2011-09-28 | 東芝モバイルディスプレイ株式会社 | 平面表示装置及びその駆動方法 |
TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
JP5255994B2 (ja) * | 2008-11-04 | 2013-08-07 | 国立大学法人 岡山大学 | 核内受容体リガンド |
CN102260214B (zh) * | 2009-12-29 | 2013-12-04 | 浙江大学 | 一种吲唑化合物的制备方法 |
BR102012000187A2 (pt) * | 2012-01-05 | 2018-04-10 | Univ Rio De Janeiro | Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos |
CN102653521B (zh) * | 2012-04-27 | 2014-08-06 | 首都师范大学 | 吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途 |
CA2877526A1 (en) | 2012-06-20 | 2013-12-27 | Novartis Ag | Complement pathway modulators and uses thereof |
CN104337812B (zh) | 2013-07-29 | 2018-09-14 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其使用方法和用途 |
US9714232B2 (en) | 2013-12-20 | 2017-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
CN105078993B (zh) * | 2015-08-26 | 2019-02-22 | 浙江大果生物医药科技有限公司 | 一种吲唑类化合物组合物及其制备方法和应用 |
CN105061317B (zh) * | 2015-08-26 | 2017-08-25 | 浙江大果生物医药科技有限公司 | 一类吲唑盐类化合物及其制备方法和应用 |
CN106632268A (zh) * | 2016-11-18 | 2017-05-10 | 河南师范大学 | 用于治疗脑源性疾病的钙调蛋白抑制剂的合成方法 |
CN110407752A (zh) * | 2019-08-22 | 2019-11-05 | 浙江大果生物医药科技有限公司 | 一种药物的草酸盐晶型及其制备方法 |
TWI749881B (zh) * | 2019-11-21 | 2021-12-11 | 大陸商深圳信立泰藥業股份有限公司 | 二氧代哌類衍生物、其製備方法及其在醫藥上的應用 |
CN112608303B (zh) * | 2020-12-25 | 2021-10-26 | 华南理工大学 | 一种哌嗪类中间体及其制备方法与应用 |
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US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US4510307A (en) * | 1980-08-20 | 1985-04-09 | Asahi Kasei Kogyo Kabushiki Kaisha | 6-Quinazolinesulfonyl derivatives and process for preparation thereof |
US4544657A (en) * | 1983-05-19 | 1985-10-01 | Hoffmann-La Roche Inc. | Substituted isoquinolines |
GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
-
1994
- 1994-05-12 RU RU94016183/04A patent/RU2124511C1/ru not_active IP Right Cessation
- 1994-05-13 NO NO941802A patent/NO306901B1/no not_active IP Right Cessation
- 1994-05-13 SI SI9430169T patent/SI0624584T1/xx not_active IP Right Cessation
- 1994-05-13 AT AT94107496T patent/ATE169914T1/de not_active IP Right Cessation
- 1994-05-13 CA CA002123548A patent/CA2123548C/en not_active Expired - Fee Related
- 1994-05-13 FI FI942252A patent/FI942252A/fi unknown
- 1994-05-13 AU AU63096/94A patent/AU677644B2/en not_active Ceased
- 1994-05-13 JP JP09939194A patent/JP3220591B2/ja not_active Expired - Fee Related
- 1994-05-13 DE DE69412534T patent/DE69412534T2/de not_active Expired - Fee Related
- 1994-05-13 DK DK94107496T patent/DK0624584T3/da active
- 1994-05-13 SG SG1996003753A patent/SG48920A1/en unknown
- 1994-05-13 ES ES94107496T patent/ES2125372T3/es not_active Expired - Lifetime
- 1994-05-13 CN CN94105810A patent/CN1049654C/zh not_active Expired - Fee Related
- 1994-05-13 EP EP94107496A patent/EP0624584B1/en not_active Expired - Lifetime
- 1994-05-14 KR KR1019940010542A patent/KR100303737B1/ko not_active IP Right Cessation
- 1994-05-25 TW TW083104731A patent/TW418198B/zh not_active IP Right Cessation
- 1994-11-22 EE EE9400389A patent/EE03139B1/xx not_active IP Right Cessation
-
1997
- 1997-06-17 AU AU24952/97A patent/AU698486B2/en not_active Ceased
-
1998
- 1998-01-21 HK HK98100555A patent/HK1002221A1/xx not_active IP Right Cessation
- 1998-08-20 GR GR980401824T patent/GR3027679T3/el unknown
-
2001
- 2001-06-13 JP JP2001178197A patent/JP2002053553A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
FI942252A0 (fi) | 1994-05-13 |
SI0624584T1 (en) | 1998-10-31 |
AU677644B2 (en) | 1997-05-01 |
TW418198B (en) | 2001-01-11 |
CA2123548C (en) | 2003-04-08 |
JP3220591B2 (ja) | 2001-10-22 |
DK0624584T3 (da) | 1999-05-25 |
FI942252A (fi) | 1994-11-15 |
AU698486B2 (en) | 1998-10-29 |
NO941802D0 (no) | 1994-05-13 |
HK1002221A1 (en) | 1998-08-07 |
AU6309694A (en) | 1994-11-17 |
SG48920A1 (en) | 1998-05-18 |
ATE169914T1 (de) | 1998-09-15 |
CN1101039A (zh) | 1995-04-05 |
EP0624584A1 (en) | 1994-11-17 |
KR100303737B1 (ko) | 2001-11-22 |
EE03139B1 (et) | 1998-12-15 |
RU2124511C1 (ru) | 1999-01-10 |
GR3027679T3 (en) | 1998-11-30 |
DE69412534D1 (de) | 1998-09-24 |
EP0624584B1 (en) | 1998-08-19 |
AU2495297A (en) | 1997-09-04 |
JPH0797364A (ja) | 1995-04-11 |
RU94016183A (ru) | 1996-04-10 |
CA2123548A1 (en) | 1994-11-15 |
JP2002053553A (ja) | 2002-02-19 |
DE69412534T2 (de) | 1999-04-29 |
NO941802L (no) | 1994-11-15 |
ES2125372T3 (es) | 1999-03-01 |
CN1049654C (zh) | 2000-02-23 |
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