NO306194B1 - Tolags fosfolipidvesikkel, fremgangsmåte til fremstilling og anvendelse derav, samt farmasöytisk preparat som omfatter vesikkelen - Google Patents
Tolags fosfolipidvesikkel, fremgangsmåte til fremstilling og anvendelse derav, samt farmasöytisk preparat som omfatter vesikkelen Download PDFInfo
- Publication number
- NO306194B1 NO306194B1 NO923703A NO923703A NO306194B1 NO 306194 B1 NO306194 B1 NO 306194B1 NO 923703 A NO923703 A NO 923703A NO 923703 A NO923703 A NO 923703A NO 306194 B1 NO306194 B1 NO 306194B1
- Authority
- NO
- Norway
- Prior art keywords
- membrane
- accordance
- weight
- phospholipid
- vesicles
- Prior art date
Links
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000004927 fusion Effects 0.000 claims abstract description 59
- 239000003814 drug Substances 0.000 claims abstract description 46
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 41
- 229940079593 drug Drugs 0.000 claims abstract description 40
- 239000000185 hemagglutinin Substances 0.000 claims abstract description 32
- 101710154606 Hemagglutinin Proteins 0.000 claims abstract description 31
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims abstract description 31
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims abstract description 31
- 101710176177 Protein A56 Proteins 0.000 claims abstract description 31
- 239000012528 membrane Substances 0.000 claims abstract description 28
- 241000700605 Viruses Species 0.000 claims abstract description 24
- 239000003599 detergent Substances 0.000 claims abstract description 24
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract description 20
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims abstract description 16
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims abstract description 16
- 239000004793 Polystyrene Substances 0.000 claims abstract description 10
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 10
- 229920002223 polystyrene Polymers 0.000 claims abstract description 10
- 239000003550 marker Substances 0.000 claims abstract description 9
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 5
- YYELLDKEOUKVIQ-UHFFFAOYSA-N octaethyleneglycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO YYELLDKEOUKVIQ-UHFFFAOYSA-N 0.000 claims abstract description 5
- -1 sulfosuccinimidyl Chemical group 0.000 claims abstract description 4
- 201000009030 Carcinoma Diseases 0.000 claims abstract description 3
- 239000003431 cross linking reagent Substances 0.000 claims description 19
- 108010015937 ribonuclease dimer Proteins 0.000 claims description 17
- 230000003612 virological effect Effects 0.000 claims description 17
- 229960000633 dextran sulfate Drugs 0.000 claims description 15
- 238000005199 ultracentrifugation Methods 0.000 claims description 14
- 241000712461 unidentified influenza virus Species 0.000 claims description 14
- 239000013638 trimer Substances 0.000 claims description 10
- UJMHIOBAHVUDGS-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-(2-decoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO UJMHIOBAHVUDGS-UHFFFAOYSA-N 0.000 claims description 9
- 239000000178 monomer Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 102000002068 Glycopeptides Human genes 0.000 claims description 7
- 108010015899 Glycopeptides Proteins 0.000 claims description 7
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims description 7
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims description 6
- 241000710961 Semliki Forest virus Species 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- NMIZONYLXCOHEF-UHFFFAOYSA-N 1h-imidazole-2-carboxamide Chemical compound NC(=O)C1=NC=CN1 NMIZONYLXCOHEF-UHFFFAOYSA-N 0.000 claims description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 5
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- 239000011324 bead Substances 0.000 claims description 5
- 230000001588 bifunctional effect Effects 0.000 claims description 5
- 229960002949 fluorouracil Drugs 0.000 claims description 5
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims description 4
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 229960001338 colchicine Drugs 0.000 claims description 3
- 230000009385 viral infection Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000005453 pelletization Methods 0.000 claims description 2
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 3
- 102000016943 Muramidase Human genes 0.000 claims 3
- 108010014251 Muramidase Proteins 0.000 claims 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 229960000274 lysozyme Drugs 0.000 claims 3
- 235000010335 lysozyme Nutrition 0.000 claims 3
- 239000004325 lysozyme Substances 0.000 claims 3
- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- WHLATLJVYMNVTJ-UHFFFAOYSA-N methyl n-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl)carbamate Chemical compound C1=C(OC)C(=O)C=C2C(NC(=O)OC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 WHLATLJVYMNVTJ-UHFFFAOYSA-N 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 abstract description 5
- 238000011160 research Methods 0.000 abstract description 3
- 230000004071 biological effect Effects 0.000 abstract description 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 239000004971 Cross linker Substances 0.000 abstract 1
- 239000002502 liposome Substances 0.000 description 41
- 239000000243 solution Substances 0.000 description 37
- 210000004027 cell Anatomy 0.000 description 30
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 206010022000 influenza Diseases 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 11
- 239000000725 suspension Substances 0.000 description 11
- 239000008188 pellet Substances 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 230000012202 endocytosis Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000000277 virosome Substances 0.000 description 6
- 238000012377 drug delivery Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 206010057249 Phagocytosis Diseases 0.000 description 4
- 238000011579 SCID mouse model Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000003443 antiviral agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 210000000805 cytoplasm Anatomy 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000008782 phagocytosis Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 241000711798 Rabies lyssavirus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 241000711975 Vesicular stomatitis virus Species 0.000 description 3
- 108010093857 Viral Hemagglutinins Proteins 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000002845 virion Anatomy 0.000 description 3
- HBZSTRIPIRCTOW-UHFFFAOYSA-N 2-morpholin-2-ylethanesulfonic acid hydrate Chemical compound O.OS(=O)(=O)CCC1CNCCO1 HBZSTRIPIRCTOW-UHFFFAOYSA-N 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- 101710146275 Hemagglutinin 2 Proteins 0.000 description 2
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 2
- 241000712431 Influenza A virus Species 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 210000001840 diploid cell Anatomy 0.000 description 2
- 210000001163 endosome Anatomy 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229960001330 hydroxycarbamide Drugs 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 210000001539 phagocyte Anatomy 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 2
- 230000001839 systemic circulation Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000009210 therapy by ultrasound Methods 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101800000585 Diphtheria toxin fragment A Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 101710146287 Hemagglutinin 1 Proteins 0.000 description 1
- 101710121925 Hemagglutinin glycoprotein Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000798731 Homo sapiens Transmembrane 9 superfamily member 3 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000711408 Murine respirovirus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010037742 Rabies Diseases 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 102100032504 Transmembrane 9 superfamily member 3 Human genes 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 229940064734 aminobenzoate Drugs 0.000 description 1
- 229940125644 antibody drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000036983 biotransformation Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 210000003040 circulating cell Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001566 pro-viral effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000007332 vesicle formation Effects 0.000 description 1
- 230000006394 virus-host interaction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Feedback Control In General (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Air Conditioning Control Device (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91101414A EP0497997B1 (en) | 1991-02-02 | 1991-02-02 | Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems |
| PCT/EP1992/000089 WO1992013525A1 (en) | 1991-02-02 | 1992-01-17 | Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923703D0 NO923703D0 (no) | 1992-09-24 |
| NO923703L NO923703L (no) | 1992-11-26 |
| NO306194B1 true NO306194B1 (no) | 1999-10-04 |
Family
ID=8206362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923703A NO306194B1 (no) | 1991-02-02 | 1992-09-24 | Tolags fosfolipidvesikkel, fremgangsmåte til fremstilling og anvendelse derav, samt farmasöytisk preparat som omfatter vesikkelen |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6040167A (es) |
| EP (1) | EP0497997B1 (es) |
| JP (1) | JP3404037B2 (es) |
| KR (1) | KR100205693B1 (es) |
| AT (1) | ATE125154T1 (es) |
| AU (1) | AU657730B2 (es) |
| BG (1) | BG61215B1 (es) |
| BR (1) | BR9204116A (es) |
| CA (1) | CA2079685C (es) |
| DE (1) | DE69111414T2 (es) |
| DK (1) | DK0497997T3 (es) |
| ES (1) | ES2077086T3 (es) |
| FI (1) | FI109969B (es) |
| GE (1) | GEP20002229B (es) |
| GR (1) | GR3017490T3 (es) |
| HK (1) | HK56696A (es) |
| HU (1) | HU215533B (es) |
| NO (1) | NO306194B1 (es) |
| PL (2) | PL296382A1 (es) |
| RO (1) | RO114736B1 (es) |
| RU (1) | RU2125868C1 (es) |
| WO (1) | WO1992013525A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5603872A (en) * | 1991-02-14 | 1997-02-18 | Baxter International Inc. | Method of binding recognizing substances to liposomes |
| JP3407072B2 (ja) * | 1991-02-14 | 2003-05-19 | バクスター、インターナショナル、インコーポレイテッド | リポソームへの認識物質の結合 |
| US7097839B1 (en) * | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
| US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
| ATE223701T1 (de) * | 1994-05-31 | 2002-09-15 | Inex Pharmaceutical Corp | Intrazelluläre verabreichung therapeutischer sustanzenmittels virosomen |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US5908777A (en) * | 1995-06-23 | 1999-06-01 | University Of Pittsburgh | Lipidic vector for nucleic acid delivery |
| AU6691496A (en) * | 1995-08-01 | 1997-02-26 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
| HUP9901790A3 (en) * | 1996-05-08 | 2010-11-29 | Nika Health Products Ltd | Cationic virosomes as transfer system for genetic material |
| US7148324B1 (en) | 1998-12-14 | 2006-12-12 | Dendreon Corporation | Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation |
| CA2353816C (en) * | 1998-12-14 | 2010-06-01 | Dendreon Corporation | Compositions and methods for enhancement of major histocompatibility complex class i restricted antigen presentation |
| JP2004513059A (ja) | 1998-12-24 | 2004-04-30 | ユセベ，ソシエテ アノニム | ペプチド産物、方法及び組成物 |
| ATE258428T1 (de) * | 1999-10-08 | 2004-02-15 | Nika Health Products Ltd | Kationische dosper virosomen |
| BR0016472A (pt) * | 1999-12-17 | 2002-08-20 | Cápsula de ignição indutivamente ativável para sistemas de retenção de ocupantes de assento | |
| US20040028687A1 (en) * | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
| US20040176283A1 (en) * | 2002-04-01 | 2004-09-09 | Robinson John A. | Methods and compositions for the design of synthetic vaccines |
| DK1499294T3 (da) * | 2002-04-29 | 2010-12-06 | Biotesys Gmbh | Polymeriserede, peptid-modificerede lipider som biologiske transportsystemer til mikronæringsstoffer |
| EP1447080A1 (en) * | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Method for producing virosome-like particles |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| KR101376895B1 (ko) | 2004-05-03 | 2014-03-25 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| US20070160658A1 (en) * | 2005-10-20 | 2007-07-12 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| JP5606067B2 (ja) | 2006-09-15 | 2014-10-15 | オタワ ホスピタル リサーチ インスティテュート | 腫瘍崩壊性ラブドウイルス |
| CA3001467A1 (en) | 2015-10-16 | 2017-04-20 | Ipsen Biopharm Ltd. | Stabilizing camptothecin pharmaceutical compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3173713D1 (en) * | 1980-09-05 | 1986-03-20 | Frappier Armand Inst | Formation of an immunosome exclusively made of viral antigens reconstituted on an artificial membrane |
| US4663161A (en) * | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
| US4871488A (en) * | 1985-04-22 | 1989-10-03 | Albany Medical College Of Union University | Reconstituting viral glycoproteins into large phospholipid vesicles |
| US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
| US5000960A (en) * | 1987-03-13 | 1991-03-19 | Micro-Pak, Inc. | Protein coupling to lipid vesicles |
| IL86650A0 (en) * | 1987-06-30 | 1988-11-30 | Biophor Corp | Animal derived cells and liposomes,having an antigenic protein incorporated into their membrane |
| WO1991003258A1 (en) * | 1989-09-01 | 1991-03-21 | Board Of Regents, The University Of Texas System | Immunoliposomes for transmittal of activating signals to cells |
| AU652778B2 (en) * | 1990-10-15 | 1994-09-08 | Quest International B.V. | Treatment composition |
-
1991
- 1991-01-17 PL PL29638291A patent/PL296382A1/xx unknown
- 1991-02-02 DE DE69111414T patent/DE69111414T2/de not_active Expired - Fee Related
- 1991-02-02 AT AT91101414T patent/ATE125154T1/de not_active IP Right Cessation
- 1991-02-02 DK DK91101414.0T patent/DK0497997T3/da active
- 1991-02-02 EP EP91101414A patent/EP0497997B1/en not_active Expired - Lifetime
- 1991-02-02 ES ES91101414T patent/ES2077086T3/es not_active Expired - Lifetime
-
1992
- 1992-01-17 CA CA002079685A patent/CA2079685C/en not_active Expired - Fee Related
- 1992-01-17 RO RO92-01271A patent/RO114736B1/ro unknown
- 1992-01-17 JP JP50347192A patent/JP3404037B2/ja not_active Expired - Fee Related
- 1992-01-17 WO PCT/EP1992/000089 patent/WO1992013525A1/en active IP Right Grant
- 1992-01-17 US US07/930,593 patent/US6040167A/en not_active Expired - Fee Related
- 1992-01-17 BR BR929204116A patent/BR9204116A/pt not_active Application Discontinuation
- 1992-01-17 GE GEAP19921215A patent/GEP20002229B/en unknown
- 1992-01-17 HU HU9203141A patent/HU215533B/hu not_active IP Right Cessation
- 1992-01-17 AU AU11693/92A patent/AU657730B2/en not_active Ceased
- 1992-01-17 PL PL92296382A patent/PL170169B1/pl not_active IP Right Cessation
- 1992-01-17 RU SU5053247A patent/RU2125868C1/ru not_active IP Right Cessation
- 1992-09-24 NO NO923703A patent/NO306194B1/no not_active IP Right Cessation
- 1992-09-29 BG BG96928A patent/BG61215B1/bg unknown
- 1992-10-01 FI FI924418A patent/FI109969B/fi active
- 1992-10-01 KR KR1019920702402A patent/KR100205693B1/ko not_active IP Right Cessation
-
1995
- 1995-09-21 GR GR950402607T patent/GR3017490T3/el unknown
-
1996
- 1996-03-28 HK HK56696A patent/HK56696A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2079685C (en) | 2001-11-27 |
| NO923703D0 (no) | 1992-09-24 |
| ATE125154T1 (de) | 1995-08-15 |
| ES2077086T3 (es) | 1995-11-16 |
| HU9203141D0 (en) | 1992-12-28 |
| FI924418A0 (fi) | 1992-10-01 |
| DE69111414T2 (de) | 1996-02-01 |
| GR3017490T3 (en) | 1995-12-31 |
| RU2125868C1 (ru) | 1999-02-10 |
| DK0497997T3 (da) | 1995-11-27 |
| BR9204116A (pt) | 1993-06-08 |
| EP0497997B1 (en) | 1995-07-19 |
| AU1169392A (en) | 1992-09-07 |
| BG61215B1 (en) | 1997-03-31 |
| PL296382A1 (en) | 1993-11-02 |
| JP3404037B2 (ja) | 2003-05-06 |
| FI924418A (fi) | 1993-04-03 |
| NO923703L (no) | 1992-11-26 |
| US6040167A (en) | 2000-03-21 |
| PL170169B1 (en) | 1996-10-31 |
| RO114736B1 (ro) | 1999-07-30 |
| HUT66194A (en) | 1994-10-28 |
| HK56696A (en) | 1996-04-12 |
| HU215533B (hu) | 1999-01-28 |
| DE69111414D1 (de) | 1995-08-24 |
| FI109969B (fi) | 2002-11-15 |
| KR100205693B1 (en) | 1999-07-01 |
| WO1992013525A1 (en) | 1992-08-20 |
| AU657730B2 (en) | 1995-03-23 |
| BG96928A (bg) | 1994-03-24 |
| CA2079685A1 (en) | 1992-08-03 |
| EP0497997A1 (en) | 1992-08-12 |
| GEP20002229B (en) | 2000-09-25 |
| JPH05505406A (ja) | 1993-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO306194B1 (no) | Tolags fosfolipidvesikkel, fremgangsmåte til fremstilling og anvendelse derav, samt farmasöytisk preparat som omfatter vesikkelen | |
| Nisini et al. | The multirole of liposomes in therapy and prevention of infectious diseases | |
| Espuelas et al. | Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomes | |
| Huckriede et al. | Influenza virosomes in vaccine development | |
| DE69229703T2 (de) | Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende Impfstoffe | |
| H. Ucisik et al. | Emulsomes meet S-layer proteins: an emerging targeted drug delivery system | |
| TWI672149B (zh) | 改良之疫苗組成物及使用方法 | |
| US4148876A (en) | Biological preparations | |
| US10159729B2 (en) | Antigen and method for production thereof | |
| KR101290475B1 (ko) | 인플루엔자 바이러스 및 비형 간염 바이러스로부터의항원을 포함하는 비로좀 입자 | |
| Tiwari et al. | Viral protein complexed liposomes for intranasal delivery of hepatitis B surface antigen | |
| Bhattacharya et al. | Virosomes: A novel strategy for drug delivery and targeting | |
| CA1079634A (en) | Antigens bound to exterior surface of microvesicles | |
| de Jonge et al. | Use of a dialyzable short-chain phospholipid for efficient solubilization and reconstitution of influenza virus envelopes | |
| Ali et al. | Virosome: An engineered virus for vaccine delivery | |
| Park et al. | Chemical and biological conjugation strategies for the development of multivalent protein vaccine nanoparticles | |
| US20160256388A1 (en) | Compositions and methods for treatment of respiratory tract infections | |
| Rathore et al. | Virosomes: a novel vaccination technology | |
| Garnier et al. | Enhancement of in vivo and in vitro T cell response against measles virus haemagglutinin after its incorporation into liposomes: effect of the phospholipid composition | |
| DE69127975T2 (de) | Impfstoffe | |
| Metcalfe et al. | Virosomes for vaccine delivery | |
| HU219353B (en) | Synthetic membrane vesicles as vehicles containing functionally active fusional peptides and pharmaceutical compositions comprising them | |
| EP4108251A1 (en) | Griffithsin for use in a method of preventing or treating infections with respiratory viruses | |
| Fand et al. | VIROSOMES AS AN INNOVATIVE DRUG DELIVERY SYSTEM | |
| Sugahara et al. | Preparation of cationic immunovesicles containing cationic peptide lipid for specific drug delivery to target cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |