NO304794B1 - Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder - Google Patents

Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder

Info

Publication number
NO304794B1
NO304794B1 NO941678A NO941680A NO304794B1 NO 304794 B1 NO304794 B1 NO 304794B1 NO 941678 A NO941678 A NO 941678A NO 941680 A NO941680 A NO 941680A NO 304794 B1 NO304794 B1 NO 304794B1
Authority
NO
Norway
Prior art keywords
preparation
acid derivatives
bile acid
hypolipidemics
medicinal preparations
Prior art date
Application number
NO941678A
Other languages
English (en)
Norwegian (no)
Other versions
NO941680L (no
NO941680D0 (no
Inventor
Heiner Glombik
Alfons Enhsen
Werner Kramer
Gunther Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO941680D0 publication Critical patent/NO941680D0/no
Publication of NO941680L publication Critical patent/NO941680L/no
Publication of NO304794B1 publication Critical patent/NO304794B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO941678A 1993-05-08 1994-05-06 Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder NO304794B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315439 1993-05-08

Publications (3)

Publication Number Publication Date
NO941680D0 NO941680D0 (no) 1994-05-06
NO941680L NO941680L (no) 1994-11-09
NO304794B1 true NO304794B1 (no) 1999-02-15

Family

ID=6487634

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941678A NO304794B1 (no) 1993-05-08 1994-05-06 Monomere gallesyrederivater, hypolipidemika inneholdende dem og deres anvendelse for fremstilling av legemilder

Country Status (18)

Country Link
US (1) US5610151A (enExample)
EP (1) EP0624594B1 (enExample)
JP (1) JP3424978B2 (enExample)
KR (1) KR100333151B1 (enExample)
AT (1) ATE183191T1 (enExample)
AU (1) AU673419B2 (enExample)
CA (1) CA2123052C (enExample)
CZ (1) CZ289209B6 (enExample)
DE (1) DE59408602D1 (enExample)
DK (1) DK0624594T3 (enExample)
ES (1) ES2136677T3 (enExample)
FI (1) FI942077A7 (enExample)
GR (1) GR3031541T3 (enExample)
HU (1) HUT67574A (enExample)
IL (1) IL109580A (enExample)
NO (1) NO304794B1 (enExample)
NZ (1) NZ260471A (enExample)
TW (1) TW289021B (enExample)

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DK0573848T3 (da) * 1992-06-12 1998-08-10 Hoechst Ag Galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemidler
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US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE19845403B4 (de) * 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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KR20010099937A (ko) * 1998-12-23 2001-11-09 윌리암스 로저 에이 심혈관 징후용 콜레스테릴 에스테르 전달 단백질 억제제및 피브르산 유도체의 조합물
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WO2000038723A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
US6562860B1 (en) * 1998-12-23 2003-05-13 G. D. Searle & Co. Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
DE19941764A1 (de) * 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
NZ517899A (en) * 1999-09-22 2004-03-26 Aventis Pharma Gmbh 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
AU2001247331A1 (en) * 2000-03-10 2001-09-24 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6624155B2 (en) * 2001-05-01 2003-09-23 Board Of Trustees Of The University Of Arkansas Hybrid cholinergic agents and compositions
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
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ES2973355T3 (es) 2019-12-04 2024-06-19 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
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JP7696898B2 (ja) 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
TWI865673B (zh) 2019-12-04 2024-12-11 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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KR20250110930A (ko) 2022-12-09 2025-07-21 알비레오 에이비 신장 질병 치료용 asbt 억제제
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Also Published As

Publication number Publication date
IL109580A (en) 1999-03-12
GR3031541T3 (en) 2000-01-31
DK0624594T3 (da) 1999-12-13
ES2136677T3 (es) 1999-12-01
HUT67574A (en) 1995-04-28
AU6194994A (en) 1994-11-10
NO941680L (no) 1994-11-09
EP0624594A3 (de) 1996-05-01
KR100333151B1 (ko) 2002-09-04
CZ113794A3 (en) 1994-11-16
FI942077L (fi) 1994-11-09
FI942077A0 (fi) 1994-05-05
EP0624594B1 (de) 1999-08-11
JP3424978B2 (ja) 2003-07-07
EP0624594A2 (de) 1994-11-17
NZ260471A (en) 1995-04-27
FI942077A7 (fi) 1994-11-09
TW289021B (enExample) 1996-10-21
DE59408602D1 (de) 1999-09-16
JPH072891A (ja) 1995-01-06
IL109580A0 (en) 1994-08-26
CA2123052A1 (en) 1994-11-09
NO941680D0 (no) 1994-05-06
US5610151A (en) 1997-03-11
CA2123052C (en) 2005-04-26
ATE183191T1 (de) 1999-08-15
HU9401408D0 (en) 1994-08-29
AU673419B2 (en) 1996-11-07
CZ289209B6 (cs) 2001-12-12

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