NO303577B1 - AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner - Google Patents

AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner

Info

Publication number
NO303577B1
NO303577B1 NO930898A NO930898A NO303577B1 NO 303577 B1 NO303577 B1 NO 303577B1 NO 930898 A NO930898 A NO 930898A NO 930898 A NO930898 A NO 930898A NO 303577 B1 NO303577 B1 NO 303577B1
Authority
NO
Norway
Prior art keywords
carbons
lower alkyl
independently
benzoxazines
imidazolidine
Prior art date
Application number
NO930898A
Other languages
English (en)
Norwegian (no)
Other versions
NO930898L (no
NO930898D0 (no
Inventor
Charles Gluchowski
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of NO930898D0 publication Critical patent/NO930898D0/no
Publication of NO930898L publication Critical patent/NO930898L/no
Publication of NO303577B1 publication Critical patent/NO303577B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Cosmetics (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO930898A 1990-09-12 1993-03-11 AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner NO303577B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/582,034 US5091528A (en) 1990-09-12 1990-09-12 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
PCT/US1991/006519 WO1992004345A1 (en) 1990-09-12 1991-09-10 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS

Publications (3)

Publication Number Publication Date
NO930898D0 NO930898D0 (no) 1993-03-11
NO930898L NO930898L (no) 1993-05-10
NO303577B1 true NO303577B1 (no) 1998-08-03

Family

ID=24327570

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930898A NO303577B1 (no) 1990-09-12 1993-03-11 AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner

Country Status (17)

Country Link
US (1) US5091528A (pt)
EP (1) EP0548254B1 (pt)
JP (1) JP3096475B2 (pt)
AT (1) ATE180782T1 (pt)
AU (1) AU646098B2 (pt)
CA (1) CA2091440C (pt)
DE (1) DE69131295T2 (pt)
ES (1) ES2132093T3 (pt)
FI (1) FI94864C (pt)
HU (1) HU220671B1 (pt)
IE (1) IE913202A1 (pt)
IL (1) IL99345A (pt)
NO (1) NO303577B1 (pt)
NZ (1) NZ239580A (pt)
PT (1) PT98959B (pt)
WO (1) WO1992004345A1 (pt)
ZA (1) ZA917218B (pt)

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US5716952A (en) * 1992-03-18 1998-02-10 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US6077839A (en) * 1992-03-19 2000-06-20 Allergan Sales, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists
US5710288A (en) * 1993-04-21 1998-01-20 Allergan 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5663189A (en) * 1993-07-01 1997-09-02 The Procter & Gamble Company 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5580892A (en) * 1993-10-22 1996-12-03 Allergan Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
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JP3805360B2 (ja) * 1994-01-24 2006-08-02 アラーガン、インコーポレイテッド α▲下２Ａ▼アドレナリン受容体作動剤としての芳香族２−アミノ−イミダゾール誘導体
AU2829395A (en) * 1994-06-16 1996-01-05 Allergan, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators
JPH10502643A (ja) * 1994-07-11 1998-03-10 アラーガン α▲下２▼アドレナリン遮断剤として有用な、立体配座の定まった二環およびアダマンタン誘導体
US6150389A (en) 1994-07-11 2000-11-21 Allergan Sales, Inc. Comformationally rigid bicyclic and adamantane derivatives useful as α2 -adrenergic blocking agents
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
AU715350B2 (en) * 1995-05-12 2000-01-20 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
AU744018B2 (en) * 1995-05-12 2002-02-14 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
US6087361A (en) * 1995-05-12 2000-07-11 Allergan Sales, Inc. Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects
US5914342A (en) * 1995-06-07 1999-06-22 The Procter & Gamble Company 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
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US6350780B1 (en) 1995-07-28 2002-02-26 Allergan Sales, Inc. Methods and compositions for drug delivery
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US6306877B1 (en) * 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
JP2001506981A (ja) * 1996-11-25 2001-05-29 ザ プロクター アンド ギャンブル カンパニー α―２アドレナリン受容体作動薬として有用な２―イミダゾリニルアミノインドール化合物
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US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
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PL340711A1 (en) 1997-11-24 2001-02-26 Procter & Gamble Derivatives of 5-(2-imidazolinamino)-benzimidazole, their production and application of them as antagonists of alpha-adrenergic receptors of improved metabolic stability
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Also Published As

Publication number Publication date
FI94864B (fi) 1995-07-31
ZA917218B (en) 1992-06-24
AU646098B2 (en) 1994-02-10
IL99345A0 (en) 1992-07-15
FI94864C (fi) 1995-11-10
HU9300695D0 (en) 1993-06-28
PT98959A (pt) 1992-07-31
US5091528A (en) 1992-02-25
IE913202A1 (en) 1992-02-25
WO1992004345A1 (en) 1992-03-19
AU8643691A (en) 1992-03-30
PT98959B (pt) 1999-02-26
NZ239580A (en) 1994-02-25
JP3096475B2 (ja) 2000-10-10
NO930898L (no) 1993-05-10
EP0548254B1 (en) 1999-06-02
IL99345A (en) 1998-08-16
CA2091440C (en) 2003-11-11
HU220671B1 (hu) 2002-04-29
ATE180782T1 (de) 1999-06-15
EP0548254A1 (en) 1993-06-30
FI931095A (fi) 1993-04-22
HUT65587A (en) 1994-07-28
NO930898D0 (no) 1993-03-11
JPH06501004A (ja) 1994-01-27
FI931095A0 (fi) 1993-03-11
DE69131295D1 (de) 1999-07-08
CA2091440A1 (en) 1992-03-13
DE69131295T2 (de) 2000-01-27
ES2132093T3 (es) 1999-08-16

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