NO303577B1 - AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner - Google Patents

AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner

Info

Publication number
NO303577B1
NO303577B1 NO930898A NO930898A NO303577B1 NO 303577 B1 NO303577 B1 NO 303577B1 NO 930898 A NO930898 A NO 930898A NO 930898 A NO930898 A NO 930898A NO 303577 B1 NO303577 B1 NO 303577B1
Authority
NO
Norway
Prior art keywords
carbons
lower alkyl
independently
benzoxazines
imidazolidine
Prior art date
Application number
NO930898A
Other languages
English (en)
Other versions
NO930898L (no
NO930898D0 (no
Inventor
Charles Gluchowski
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of NO930898D0 publication Critical patent/NO930898D0/no
Publication of NO930898L publication Critical patent/NO930898L/no
Publication of NO303577B1 publication Critical patent/NO303577B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Cosmetics (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
NO930898A 1990-09-12 1993-03-11 AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner NO303577B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/582,034 US5091528A (en) 1990-09-12 1990-09-12 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
PCT/US1991/006519 WO1992004345A1 (en) 1990-09-12 1991-09-10 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS

Publications (3)

Publication Number Publication Date
NO930898D0 NO930898D0 (no) 1993-03-11
NO930898L NO930898L (no) 1993-05-10
NO303577B1 true NO303577B1 (no) 1998-08-03

Family

ID=24327570

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930898A NO303577B1 (no) 1990-09-12 1993-03-11 AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner

Country Status (17)

Country Link
US (1) US5091528A (no)
EP (1) EP0548254B1 (no)
JP (1) JP3096475B2 (no)
AT (1) ATE180782T1 (no)
AU (1) AU646098B2 (no)
CA (1) CA2091440C (no)
DE (1) DE69131295T2 (no)
ES (1) ES2132093T3 (no)
FI (1) FI94864C (no)
HU (1) HU220671B1 (no)
IE (1) IE913202A1 (no)
IL (1) IL99345A (no)
NO (1) NO303577B1 (no)
NZ (1) NZ239580A (no)
PT (1) PT98959B (no)
WO (1) WO1992004345A1 (no)
ZA (1) ZA917218B (no)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281591A (en) * 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5252595A (en) * 1990-02-28 1993-10-12 Allergan, Inc. Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
US5716952A (en) * 1992-03-18 1998-02-10 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US6077839A (en) * 1992-03-19 2000-06-20 Allergan Sales, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists
US5710288A (en) * 1993-04-21 1998-01-20 Allergan 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5663189A (en) * 1993-07-01 1997-09-02 The Procter & Gamble Company 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5580892A (en) * 1993-10-22 1996-12-03 Allergan Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
CN1046718C (zh) * 1993-12-17 1999-11-24 普罗克特和甘保尔公司 用作α－2肾上腺素能受体兴奋剂的6－(2－亚咪唑烷基氨基)喹啉化合物
US5576437A (en) * 1993-12-17 1996-11-19 The Procter & Gamble Company 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
CA2179006A1 (en) * 1993-12-17 1995-06-22 Peter Julian Maurer 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
US5578607A (en) * 1993-12-17 1996-11-26 The Procter & Gamble Company 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
CA2181909C (en) * 1994-01-24 2008-10-07 Stephen A. Munk Aromatic 2-amino-imidazole derivatives as alpha-2a adrenoceptor agonists
WO1995034302A2 (en) * 1994-06-16 1995-12-21 Allergan Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators
US6150389A (en) 1994-07-11 2000-11-21 Allergan Sales, Inc. Comformationally rigid bicyclic and adamantane derivatives useful as α2 -adrenergic blocking agents
WO1996001813A1 (en) * 1994-07-11 1996-01-25 Allergan CONFORMATIONALLY RIGID BICYCLIC AND ADAMANTANE DERIVATIVES USEFUL AS α2-ADRENERGIC BLOCKING AGENTS
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
AU744018B2 (en) * 1995-05-12 2002-02-14 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
CA2220517A1 (en) * 1995-05-12 1996-11-14 Allergan Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
US6087361A (en) * 1995-05-12 2000-07-11 Allergan Sales, Inc. Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects
US5914342A (en) * 1995-06-07 1999-06-22 The Procter & Gamble Company 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5916900A (en) * 1995-06-29 1999-06-29 The Procter & Gamble Company 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
US6350780B1 (en) 1995-07-28 2002-02-26 Allergan Sales, Inc. Methods and compositions for drug delivery
US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
AU5433898A (en) * 1996-11-25 1998-06-22 Procter & Gamble Company, The 2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists
US6306877B1 (en) * 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
IL130094A (en) * 1996-11-25 2001-09-13 Procter & Gamble Compounds 2 - imidazolinylaminobenzoxazole used as agonists of alpha-adrenoreceptor 2 - and pharmaceutical preparations containing them
BR9713536A (pt) 1996-11-25 2000-11-07 Procter & Gamble Compostos heterocìclicos de guanidinila úteis como agonistas de adrenoceptores alfa-2
ID22812A (id) * 1996-11-25 1999-12-09 Procter & Gamble Senyawa 2-imidazolinilaminoindol yang berguna sebagai agonis adrenoseptor alfa-2
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
ID24081A (id) * 1997-04-15 2000-07-06 Procter & Gamble Senyawa-senyawa 5-(2-imidazolinilamino) benzimidazol yang berguna sebagai agonis-agonis alfa-2-adrenoseptor
JP2001524478A (ja) 1997-11-24 2001-12-04 ザ プロクター アンド ギャンブル カンパニー ５−（２−イミダゾリニルアミノ）−ベンゾイミダゾール誘導体類、それらの調製および改良された代謝安定性を有するアルファアドレナリン受容体作動薬としてのそれらの使用
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CZ2002711A3 (cs) * 1999-08-27 2003-11-12 Ligand Pharmaceuticals Incorporated Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
AU6941200A (en) 1999-08-27 2001-03-26 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators
WO2001019770A2 (en) 1999-09-14 2001-03-22 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
US8858961B2 (en) * 2000-07-14 2014-10-14 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US20050026924A1 (en) * 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US7345065B2 (en) * 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
CA2505836C (en) * 2004-05-06 2013-08-27 Alcon Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
CA2696314C (en) * 2007-08-15 2016-01-19 Allergan, Inc. Therapeutic compounds
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
AU2010303545B2 (en) 2009-10-06 2016-05-12 Allergan, Inc. 2H-pyrrol-5-amine derivatives as alpha adrenergic receptor modulators
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636219A (en) * 1964-03-02 1972-01-18 Du Pont Anticholinergic compositions containing certain thiazolines or imidazolines
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4587257A (en) * 1984-12-14 1986-05-06 Alcon Laboratories, Inc. Control of ocular bleeding using clonidine derivatives

Also Published As

Publication number Publication date
FI931095A0 (fi) 1993-03-11
PT98959A (pt) 1992-07-31
HUT65587A (en) 1994-07-28
IL99345A0 (en) 1992-07-15
AU646098B2 (en) 1994-02-10
ES2132093T3 (es) 1999-08-16
EP0548254B1 (en) 1999-06-02
IE913202A1 (en) 1992-02-25
JPH06501004A (ja) 1994-01-27
WO1992004345A1 (en) 1992-03-19
HU9300695D0 (en) 1993-06-28
CA2091440A1 (en) 1992-03-13
DE69131295D1 (de) 1999-07-08
AU8643691A (en) 1992-03-30
IL99345A (en) 1998-08-16
JP3096475B2 (ja) 2000-10-10
FI94864C (fi) 1995-11-10
CA2091440C (en) 2003-11-11
HU220671B1 (hu) 2002-04-29
DE69131295T2 (de) 2000-01-27
NO930898L (no) 1993-05-10
PT98959B (pt) 1999-02-26
NZ239580A (en) 1994-02-25
FI94864B (fi) 1995-07-31
EP0548254A1 (en) 1993-06-30
ZA917218B (en) 1992-06-24
NO930898D0 (no) 1993-03-11
US5091528A (en) 1992-02-25
FI931095A (fi) 1993-04-22
ATE180782T1 (de) 1999-06-15

Similar Documents

Publication Publication Date Title
NO303577B1 (no) AnalogifremgangsmÕte for fremstilling av 6- eller 7-(2-imino-2-imidazolidin)-1,4-benzoksaziner
GB2248449B (en) Piperazine derivatives
BE1003230A3 (fr) Nouveaux derives du benzotriazole, leur preparation et leur utilisation comme absorbants u.v.
HU9202953D0 (en) Method for producing quinoxaline derivatives and pharmaceutical preparatives containing these compounds
ES8407066A1 (es) Derivados de 6 -metilprednisolona.
TW328077B (en) Process for the preparation of thioamide
ATE123283T1 (de) Indolderivate, herstellung und verwendung.
RO92245B (ro) Procedeu pentru prepararea unor derivati de 1,6-naftiridina
ES476166A1 (es) Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas
GR3000877T3 (en) Substituted 2-aminotetralins
DE3271277D1 (en) Tropyl and pseudotropyl alkyl-benzoates and their use in migraine treatment
ES8308329A1 (es) "un metodo de preparar derivados de oxotienobenzoxepina".
ES8706615A1 (es) Un procedimiento para la preparacion de nuevos derivados de diamina.
ES8704477A1 (es) Procedimiento para preparar piridin-1-oxidos varias veces substituidos
FR2312255B1 (no)
CH609678A5 (en) Process for the preparation of acetamidoximes

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees