NO301482B1 - Fremgangsmåte for fremstilling av renset rekombinant human-IL-3-analogprotein som omfatter Met3huIL-3(Pro8Asp15Asp70), isolert DNA-sekvens, rekombinant ekspresjonsvektor og gjærvertscelle - Google Patents
Fremgangsmåte for fremstilling av renset rekombinant human-IL-3-analogprotein som omfatter Met3huIL-3(Pro8Asp15Asp70), isolert DNA-sekvens, rekombinant ekspresjonsvektor og gjærvertscelle Download PDFInfo
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- NO301482B1 NO301482B1 NO915116A NO915116A NO301482B1 NO 301482 B1 NO301482 B1 NO 301482B1 NO 915116 A NO915116 A NO 915116A NO 915116 A NO915116 A NO 915116A NO 301482 B1 NO301482 B1 NO 301482B1
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- yeast
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- rhuil
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/823—Lower fungi, e.g. mold
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Landscapes
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- Biophysics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/374,667 US5128450A (en) | 1989-06-30 | 1989-06-30 | Nonglycosylated human interleukin-3 analog proteins |
| PCT/US1990/003345 WO1991000350A1 (en) | 1989-06-30 | 1990-06-13 | Nonglycosylated human interleukin-3 analog proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO915116D0 NO915116D0 (no) | 1991-12-27 |
| NO915116L NO915116L (no) | 1992-02-28 |
| NO301482B1 true NO301482B1 (no) | 1997-11-03 |
Family
ID=23477728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO915116A NO301482B1 (no) | 1989-06-30 | 1991-12-27 | Fremgangsmåte for fremstilling av renset rekombinant human-IL-3-analogprotein som omfatter Met3huIL-3(Pro8Asp15Asp70), isolert DNA-sekvens, rekombinant ekspresjonsvektor og gjærvertscelle |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5128450A (ja) |
| EP (1) | EP0482013B1 (ja) |
| JP (1) | JPH04506342A (ja) |
| AT (1) | ATE138099T1 (ja) |
| AU (1) | AU630207B2 (ja) |
| CA (1) | CA2033182A1 (ja) |
| DE (1) | DE69027031T2 (ja) |
| DK (1) | DK0482013T3 (ja) |
| ES (1) | ES2090135T3 (ja) |
| FI (1) | FI916077A0 (ja) |
| NO (1) | NO301482B1 (ja) |
| WO (1) | WO1991000350A1 (ja) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
| US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
| US5705362A (en) * | 1992-05-25 | 1998-01-06 | Gist-Brocades, N.V. | Modified signal sequences |
| US5463029A (en) * | 1992-11-23 | 1995-10-31 | Immunex Corporation | Purification of fusion proteins comprising GM-CSF and IL-3 |
| US6153183A (en) * | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
| US6361976B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production |
| US6403076B1 (en) | 1992-11-24 | 2002-06-11 | S. Christopher Bauer | Compositions for increasing hematopoiesis with interleukin-3 mutants |
| US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| AU5670994A (en) | 1992-11-24 | 1994-06-22 | G.D. Searle & Co. | Interleukin-3 (il-3) mutant polypeptides |
| US5772992A (en) * | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5501962A (en) * | 1993-06-21 | 1996-03-26 | G. D. Searle & Co. | Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same |
| WO1995013089A1 (en) * | 1993-11-10 | 1995-05-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Compositions and method for stimulating antibody release by b lymphocytes |
| US6017523A (en) * | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
| DE60036915T2 (de) | 1999-01-13 | 2008-08-07 | Alchemia Oncology Pty Ltd., Hawthorn | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| EP2135611A1 (en) | 2001-03-01 | 2009-12-23 | Hollis-Eden Pharmaceuticals Inc. | Pregn-5-en-20-yne-3,7,17-triol derivatives for use in therapy |
| CA2458856C (en) * | 2001-08-27 | 2011-02-15 | Meditech Research Limited | Improved therapeutic protocols |
| JP4212827B2 (ja) * | 2002-05-16 | 2009-01-21 | シスメックス株式会社 | 骨髄液有核細胞自動分析方法 |
| JP2006506445A (ja) | 2002-08-28 | 2006-02-23 | ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド | 治療処置の方法 |
| JP2008527981A (ja) * | 2005-01-25 | 2008-07-31 | アポロ ライフ サイエンシズ リミテッド | 治療目的および診断目的のためにパラメーターにより選択されたｇｍ−ｃｓｆ、ｉｌ−３、ｉｌ−４、ｉｌ−５、ならびにそのキメラ |
| CA2616607C (en) * | 2005-07-27 | 2015-06-02 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| WO2007028196A1 (en) * | 2005-09-07 | 2007-03-15 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
| JP5628544B2 (ja) * | 2010-04-07 | 2014-11-19 | 株式会社豊田中央研究所 | クロストリジウム・サーモセラム由来のタンパク質複合体を構築するためのタンパク質及びその利用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695542A (en) * | 1983-10-04 | 1987-09-22 | Dnax Research Institute Of Molecular And Cellular Biology, Inc. | cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity |
| US4877729A (en) * | 1986-07-14 | 1989-10-31 | Genetics Institute, Inc. | Recombinant DNA encoding novel family of primate hematopoietic growth factors |
| EP0790307A1 (en) * | 1986-12-16 | 1997-08-20 | Gist-Brocades B.V. | Molecular cloning and expression of human IL-3 |
| PT86381B (pt) * | 1986-12-16 | 1990-11-20 | Gist Brocades Nv | Processo de clonagem molecular e de expressao de interleuquina-3 (il-3) humana |
| WO1988005469A1 (en) * | 1987-01-20 | 1988-07-28 | Immunex Corporation | Human interleukin-3 proteins |
| OA09736A (en) * | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
| WO1990001039A1 (en) * | 1988-07-20 | 1990-02-08 | Immunex Corporation | Nonglycosylated human interleukin-3 compositions |
-
1989
- 1989-06-30 US US07/374,667 patent/US5128450A/en not_active Expired - Lifetime
-
1990
- 1990-06-13 JP JP2508883A patent/JPH04506342A/ja active Pending
- 1990-06-13 DK DK90909318.9T patent/DK0482013T3/da active
- 1990-06-13 CA CA002033182A patent/CA2033182A1/en not_active Abandoned
- 1990-06-13 ES ES90909318T patent/ES2090135T3/es not_active Expired - Lifetime
- 1990-06-13 WO PCT/US1990/003345 patent/WO1991000350A1/en active IP Right Grant
- 1990-06-13 EP EP90909318A patent/EP0482013B1/en not_active Expired - Lifetime
- 1990-06-13 DE DE69027031T patent/DE69027031T2/de not_active Expired - Fee Related
- 1990-06-13 AU AU58216/90A patent/AU630207B2/en not_active Ceased
- 1990-06-13 AT AT90909318T patent/ATE138099T1/de not_active IP Right Cessation
-
1991
- 1991-12-20 FI FI916077A patent/FI916077A0/fi not_active Application Discontinuation
- 1991-12-27 NO NO915116A patent/NO301482B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0482013B1 (en) | 1996-05-15 |
| FI916077A0 (fi) | 1991-12-20 |
| ATE138099T1 (de) | 1996-06-15 |
| US5128450A (en) | 1992-07-07 |
| WO1991000350A1 (en) | 1991-01-10 |
| DK0482013T3 (da) | 1996-06-03 |
| NO915116L (no) | 1992-02-28 |
| AU5821690A (en) | 1991-01-17 |
| AU630207B2 (en) | 1992-10-22 |
| DE69027031D1 (de) | 1996-06-20 |
| CA2033182A1 (en) | 1990-12-31 |
| DE69027031T2 (de) | 1996-12-19 |
| NO915116D0 (no) | 1991-12-27 |
| JPH04506342A (ja) | 1992-11-05 |
| ES2090135T3 (es) | 1996-10-16 |
| EP0482013A1 (en) | 1992-04-29 |
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