NO301231B1 - 2'-deoksy-2'-fluorcoformycin og stereoisomerer av disse - Google Patents
2'-deoksy-2'-fluorcoformycin og stereoisomerer av disse Download PDFInfo
- Publication number
- NO301231B1 NO301231B1 NO941800A NO941800A NO301231B1 NO 301231 B1 NO301231 B1 NO 301231B1 NO 941800 A NO941800 A NO 941800A NO 941800 A NO941800 A NO 941800A NO 301231 B1 NO301231 B1 NO 301231B1
- Authority
- NO
- Norway
- Prior art keywords
- deoxy
- compound
- fluoro
- fluorocoformycin
- group
- Prior art date
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- YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 description 1
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- 231100000135 cytotoxicity Toxicity 0.000 description 1
- UHOVQNZJYSORNB-MICDWDOJSA-N deuteriobenzene Chemical compound [2H]C1=CC=CC=C1 UHOVQNZJYSORNB-MICDWDOJSA-N 0.000 description 1
- VOJXZEPEOLREJH-INTNWOOBSA-N diazonio-[2-[5-(dimethylaminomethylideneamino)-1-[(2r,3s,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazol-4-yl]-2-oxoethyl]azanide Chemical compound CN(C)C=NC1=C(C(=O)C[N-][N+]#N)N=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)O1 VOJXZEPEOLREJH-INTNWOOBSA-N 0.000 description 1
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- 238000010828 elution Methods 0.000 description 1
- ZKQFHRVKCYFVCN-UHFFFAOYSA-N ethoxyethane;hexane Chemical compound CCOCC.CCCCCC ZKQFHRVKCYFVCN-UHFFFAOYSA-N 0.000 description 1
- UREBWPXBXRYXRJ-UHFFFAOYSA-N ethyl acetate;methanol Chemical compound OC.CCOC(C)=O UREBWPXBXRYXRJ-UHFFFAOYSA-N 0.000 description 1
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- 201000009277 hairy cell leukemia Diseases 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
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- 238000006460 hydrolysis reaction Methods 0.000 description 1
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- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
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- VDZXAOBGHPKGCS-UHFFFAOYSA-M sodium;1,4-dioxane;hydroxide Chemical compound [OH-].[Na+].C1COCCO1 VDZXAOBGHPKGCS-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F01—MACHINES OR ENGINES IN GENERAL; ENGINE PLANTS IN GENERAL; STEAM ENGINES
- F01K—STEAM ENGINE PLANTS; STEAM ACCUMULATORS; ENGINE PLANTS NOT OTHERWISE PROVIDED FOR; ENGINES USING SPECIAL WORKING FLUIDS OR CYCLES
- F01K23/00—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids
- F01K23/02—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled
- F01K23/06—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled combustion heat from one cycle heating the fluid in another cycle
- F01K23/10—Plants characterised by more than one engine delivering power external to the plant, the engines being driven by different fluids the engine cycles being thermally coupled combustion heat from one cycle heating the fluid in another cycle with exhaust fluid of one cycle heating the fluid in another cycle
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Combustion & Propulsion (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35258891 | 1991-11-14 | ||
| PCT/JP1992/001489 WO1993010137A1 (en) | 1991-11-14 | 1992-11-13 | 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941800D0 NO941800D0 (no) | 1994-05-13 |
| NO941800L NO941800L (no) | 1994-07-04 |
| NO301231B1 true NO301231B1 (no) | 1997-09-29 |
Family
ID=18425076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941800A NO301231B1 (no) | 1991-11-14 | 1994-05-13 | 2'-deoksy-2'-fluorcoformycin og stereoisomerer av disse |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0643069B1 (da) |
| JP (1) | JP3030087B2 (da) |
| KR (1) | KR0163799B1 (da) |
| AT (1) | ATE149510T1 (da) |
| AU (1) | AU661520B2 (da) |
| CA (1) | CA2122815C (da) |
| DE (1) | DE69218005T2 (da) |
| DK (1) | DK0643069T3 (da) |
| ES (1) | ES2099841T3 (da) |
| NO (1) | NO301231B1 (da) |
| WO (1) | WO1993010137A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09241294A (ja) * | 1996-03-07 | 1997-09-16 | Microbial Chem Res Found | ２′−デオキシ−２′−ハロコホルマイシン又はその立体異性体の製造法 |
| JP6045641B1 (ja) * | 2015-06-04 | 2016-12-14 | 株式会社 資生堂 | 化粧容器 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4625020A (en) * | 1983-11-18 | 1986-11-25 | Bristol-Myers Company | Nucleoside process |
| ATE34176T1 (de) * | 1984-03-16 | 1988-05-15 | Warner Lambert Co | 2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung. |
| JPS61199797A (ja) * | 1985-02-28 | 1986-09-04 | Kitasato Inst:The | 新規化合物アデクロリンおよびその製造法 |
| JPH0631298B2 (ja) * | 1985-12-18 | 1994-04-27 | 財団法人微生物化学研究会 | 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法 |
| JPH0798832B2 (ja) * | 1987-05-01 | 1995-10-25 | 財団法人微生物化学研究会 | イミダゾジアゼピン誘導体 |
-
1992
- 1992-11-13 JP JP5509148A patent/JP3030087B2/ja not_active Expired - Lifetime
- 1992-11-13 KR KR1019940701645A patent/KR0163799B1/ko not_active IP Right Cessation
- 1992-11-13 ES ES92923538T patent/ES2099841T3/es not_active Expired - Lifetime
- 1992-11-13 DE DE69218005T patent/DE69218005T2/de not_active Expired - Fee Related
- 1992-11-13 AT AT92923538T patent/ATE149510T1/de not_active IP Right Cessation
- 1992-11-13 AU AU29318/92A patent/AU661520B2/en not_active Ceased
- 1992-11-13 EP EP92923538A patent/EP0643069B1/en not_active Expired - Lifetime
- 1992-11-13 DK DK92923538.0T patent/DK0643069T3/da active
- 1992-11-13 CA CA002122815A patent/CA2122815C/en not_active Expired - Fee Related
- 1992-11-13 WO PCT/JP1992/001489 patent/WO1993010137A1/ja active IP Right Grant
-
1994
- 1994-05-13 NO NO941800A patent/NO301231B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0643069B1 (en) | 1997-03-05 |
| AU661520B2 (en) | 1995-07-27 |
| JPH06511062A (ja) | 1994-12-08 |
| DE69218005T2 (de) | 1997-10-16 |
| EP0643069A1 (en) | 1995-03-15 |
| JP3030087B2 (ja) | 2000-04-10 |
| EP0643069A4 (en) | 1994-11-22 |
| CA2122815C (en) | 1998-09-15 |
| NO941800L (no) | 1994-07-04 |
| DE69218005D1 (de) | 1997-04-10 |
| KR0163799B1 (ko) | 1998-11-16 |
| WO1993010137A1 (en) | 1993-05-27 |
| ES2099841T3 (es) | 1997-06-01 |
| AU2931892A (en) | 1993-06-15 |
| CA2122815A1 (en) | 1993-05-27 |
| DK0643069T3 (da) | 1997-09-15 |
| NO941800D0 (no) | 1994-05-13 |
| ATE149510T1 (de) | 1997-03-15 |
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