NO301074B1 - Analogifremgangsmåte for fremstilling av terapeutisk aktive analoger av peptidasesubstrater - Google Patents
Analogifremgangsmåte for fremstilling av terapeutisk aktive analoger av peptidasesubstrater Download PDFInfo
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- NO301074B1 NO301074B1 NO894300A NO894300A NO301074B1 NO 301074 B1 NO301074 B1 NO 301074B1 NO 894300 A NO894300 A NO 894300A NO 894300 A NO894300 A NO 894300A NO 301074 B1 NO301074 B1 NO 301074B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Luminescent Compositions (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pyrrole Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Radio Relay Systems (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Inspection Of Paper Currency And Valuable Securities (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP88402735A EP0371179A1 (de) | 1988-10-28 | 1988-10-28 | Analoge von Peptidase-Substraten |
Publications (3)
Publication Number | Publication Date |
---|---|
NO894300D0 NO894300D0 (no) | 1989-10-27 |
NO894300L NO894300L (no) | 1990-04-30 |
NO301074B1 true NO301074B1 (no) | 1997-09-08 |
Family
ID=8200435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO894300A NO301074B1 (no) | 1988-10-28 | 1989-10-27 | Analogifremgangsmåte for fremstilling av terapeutisk aktive analoger av peptidasesubstrater |
Country Status (18)
Country | Link |
---|---|
US (1) | US5114927A (de) |
EP (2) | EP0371179A1 (de) |
JP (1) | JP2899327B2 (de) |
CN (1) | CN1031880C (de) |
AT (1) | ATE147405T1 (de) |
AU (1) | AU622723B2 (de) |
CA (1) | CA2001265C (de) |
DE (1) | DE68927630T2 (de) |
DK (1) | DK537589A (de) |
ES (1) | ES2099072T3 (de) |
FI (1) | FI95272C (de) |
GR (1) | GR3023027T3 (de) |
HU (1) | HU209311B (de) |
IL (1) | IL92102A (de) |
NO (1) | NO301074B1 (de) |
PH (1) | PH27239A (de) |
PT (1) | PT92140B (de) |
ZA (1) | ZA898026B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0356595A1 (de) * | 1988-09-01 | 1990-03-07 | Merrell Dow Pharmaceuticals Inc. | Peptidase-Hemmer |
ZA905737B (en) * | 1989-07-26 | 1991-05-29 | Merrell Dow Pharma | Novel peptidase inhibitors |
IE902944A1 (en) * | 1989-09-05 | 1991-03-13 | Abbott Lab | Peptidyl difluorodiol renin inhibitors |
US5714470A (en) * | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
JP3721538B2 (ja) * | 1994-06-02 | 2005-11-30 | メレル ファーマスーティカルズ インコーポレイテッド | エラスターゼのパーフルオロアルキルケトン阻害剤およびそれらを製造する方法 |
HU221310B1 (en) * | 1994-06-02 | 2002-09-28 | Merrell Pharma Inc | Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof |
US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
IL129407A0 (en) * | 1996-10-18 | 2000-02-17 | Vertex Pharma | Inhibitors of serine proteases particularly hepatitis C virus NS3 protease pharmaceutical compositions containing the same and the use thereof |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
FR2914920B1 (fr) * | 2007-04-11 | 2011-09-09 | Clariant Specialty Fine Chem F | Procede de deacetalisation d'alpha-aminoacetals. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4518528A (en) * | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
CA1341029C (en) * | 1985-02-04 | 2000-06-20 | Michael Kolb | Peptidase inhibitors |
EP0218688B1 (de) * | 1985-04-19 | 1990-09-12 | The Upjohn Company | Substituierte dihalo-statin-reninhemmungsmittel |
DE3683541D1 (de) * | 1985-06-07 | 1992-03-05 | Ici America Inc | Selektionierte difluorverbindungen. |
WO1987004349A1 (en) * | 1986-01-16 | 1987-07-30 | Joseph Dellaria | Peptide analogs |
EP0249349B1 (de) * | 1986-06-05 | 1992-10-14 | Ici Americas Inc. | Difluorketoverbindungen |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
-
1988
- 1988-10-28 EP EP88402735A patent/EP0371179A1/de not_active Withdrawn
-
1989
- 1989-10-23 CA CA002001265A patent/CA2001265C/en not_active Expired - Fee Related
- 1989-10-23 ZA ZA898026A patent/ZA898026B/xx unknown
- 1989-10-24 IL IL9210289A patent/IL92102A/en not_active IP Right Cessation
- 1989-10-27 NO NO894300A patent/NO301074B1/no not_active IP Right Cessation
- 1989-10-27 PT PT92140A patent/PT92140B/pt not_active IP Right Cessation
- 1989-10-27 AT AT89402976T patent/ATE147405T1/de not_active IP Right Cessation
- 1989-10-27 AU AU43867/89A patent/AU622723B2/en not_active Ceased
- 1989-10-27 JP JP1278753A patent/JP2899327B2/ja not_active Expired - Fee Related
- 1989-10-27 DE DE68927630T patent/DE68927630T2/de not_active Expired - Fee Related
- 1989-10-27 HU HU895473A patent/HU209311B/hu not_active IP Right Cessation
- 1989-10-27 ES ES89402976T patent/ES2099072T3/es not_active Expired - Lifetime
- 1989-10-27 DK DK537589A patent/DK537589A/da not_active Application Discontinuation
- 1989-10-27 PH PH39423A patent/PH27239A/en unknown
- 1989-10-27 EP EP89402976A patent/EP0368719B1/de not_active Expired - Lifetime
- 1989-10-27 FI FI895109A patent/FI95272C/fi not_active IP Right Cessation
- 1989-10-28 CN CN89108935A patent/CN1031880C/zh not_active Expired - Fee Related
-
1991
- 1991-09-05 US US07/759,057 patent/US5114927A/en not_active Expired - Fee Related
-
1997
- 1997-04-03 GR GR970400694T patent/GR3023027T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU895473D0 (en) | 1990-01-28 |
AU622723B2 (en) | 1992-04-16 |
EP0371179A1 (de) | 1990-06-06 |
PT92140A (pt) | 1990-04-30 |
CA2001265C (en) | 2001-05-01 |
ES2099072T3 (es) | 1997-05-16 |
EP0368719B1 (de) | 1997-01-08 |
AU4386789A (en) | 1990-05-03 |
GR3023027T3 (en) | 1997-07-30 |
US5114927A (en) | 1992-05-19 |
JP2899327B2 (ja) | 1999-06-02 |
ZA898026B (en) | 1990-07-25 |
CN1043504A (zh) | 1990-07-04 |
DE68927630T2 (de) | 1997-06-12 |
FI95272C (fi) | 1996-01-10 |
ATE147405T1 (de) | 1997-01-15 |
EP0368719A2 (de) | 1990-05-16 |
PT92140B (pt) | 1996-03-29 |
DK537589A (da) | 1990-04-29 |
DK537589D0 (da) | 1989-10-27 |
NO894300L (no) | 1990-04-30 |
EP0368719A3 (de) | 1991-10-02 |
IL92102A0 (en) | 1990-07-12 |
CN1031880C (zh) | 1996-05-29 |
DE68927630D1 (de) | 1997-02-20 |
CA2001265A1 (en) | 1990-04-28 |
NO894300D0 (no) | 1989-10-27 |
FI95272B (fi) | 1995-09-29 |
JPH02172961A (ja) | 1990-07-04 |
PH27239A (en) | 1993-05-04 |
FI895109A0 (fi) | 1989-10-27 |
HU209311B (en) | 1994-04-28 |
IL92102A (en) | 1994-07-31 |
HUT51649A (en) | 1990-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |