NO301018B1 - Tverrbundne nitrogeninneholdende vinylkopolymerer, fremgangsmåte for fremstilling av dem samt anvendelse av slike forbindelser - Google Patents
Tverrbundne nitrogeninneholdende vinylkopolymerer, fremgangsmåte for fremstilling av dem samt anvendelse av slike forbindelser Download PDFInfo
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- NO301018B1 NO301018B1 NO932635A NO932635A NO301018B1 NO 301018 B1 NO301018 B1 NO 301018B1 NO 932635 A NO932635 A NO 932635A NO 932635 A NO932635 A NO 932635A NO 301018 B1 NO301018 B1 NO 301018B1
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 10
- 229920006163 vinyl copolymer Polymers 0.000 title claims abstract description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- -1 phenoxy- Chemical class 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 238000007334 copolymerization reaction Methods 0.000 claims description 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 125000005018 aryl alkenyl group Chemical group 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims description 2
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- 108010007979 Glycocholic Acid Proteins 0.000 claims description 2
- RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 2
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- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims description 2
- RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 claims description 2
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- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims description 2
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 22
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- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 5
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- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 4
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- CYIGRWUIQAVBFG-UHFFFAOYSA-N 1,2-bis(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOCCOC=C CYIGRWUIQAVBFG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F259/00—Macromolecular compounds obtained by polymerising monomers on to polymers of halogen containing monomers as defined in group C08F14/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/12—Hydrolysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2810/00—Chemical modification of a polymer
- C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Tires In General (AREA)
- Cell Separators (AREA)
- Developing Agents For Electrophotography (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4224110 | 1992-07-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO932635D0 NO932635D0 (no) | 1993-07-21 |
| NO932635L NO932635L (no) | 1994-01-24 |
| NO301018B1 true NO301018B1 (no) | 1997-09-01 |
Family
ID=6463789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO932635A NO301018B1 (no) | 1992-07-22 | 1993-07-21 | Tverrbundne nitrogeninneholdende vinylkopolymerer, fremgangsmåte for fremstilling av dem samt anvendelse av slike forbindelser |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5428112A (fr) |
| EP (1) | EP0580079B1 (fr) |
| JP (1) | JPH06157671A (fr) |
| KR (1) | KR940005692A (fr) |
| AT (1) | ATE146193T1 (fr) |
| AU (1) | AU659562B2 (fr) |
| CA (1) | CA2101010A1 (fr) |
| DE (1) | DE59304725D1 (fr) |
| DK (1) | DK0580079T3 (fr) |
| ES (1) | ES2096150T3 (fr) |
| FI (1) | FI933274A (fr) |
| GR (1) | GR3022135T3 (fr) |
| IL (1) | IL106421A (fr) |
| NO (1) | NO301018B1 (fr) |
| NZ (1) | NZ248193A (fr) |
| ZA (1) | ZA935267B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| DE19520092A1 (de) * | 1995-06-01 | 1996-12-05 | Bayer Ag | Verfahren zur Papierveredlung unter Verwendung von Polyisocyanaten mit anionischen Gruppen |
| US6491903B1 (en) | 1996-06-27 | 2002-12-10 | Washington University | Particles comprising amphiphilic copolymers |
| DE19633268A1 (de) * | 1996-08-19 | 1998-02-26 | Hoechst Ag | Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| DE19705992A1 (de) * | 1997-02-17 | 1998-08-20 | Basf Ag | Verfahren zur Herstellung von Carbamateinheiten enthaltenden Polymerisaten und ihre Verwendung |
| US5925379A (en) * | 1997-03-27 | 1999-07-20 | Geltex Pharmaceuticals, Inc. | Interpenetrating polymer networks for sequestration of bile acids |
| US6423754B1 (en) * | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| FR2766194A1 (fr) * | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charge negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| FR2766195A1 (fr) * | 1997-07-21 | 1999-01-22 | Transgene Sa | Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| AT409630B (de) * | 2000-12-13 | 2002-09-25 | Dsm Fine Chem Austria Gmbh | Alkylierung von n-bzw. amino- oder ammoniumgruppen haltigen, vernetzten polymeren |
| EP1458769B1 (fr) * | 2001-12-21 | 2008-12-31 | Ciba Holding Inc. | Copolymeres de poly(vinyl alcool)-co-poly(n-vinyl formamide) |
| EP1456250B1 (fr) | 2001-12-21 | 2009-01-14 | Ciba Holding Inc. | Polymeres poly(vinylalcool)-co-poly(vinylamine) comportant des fractions fonctionnelles |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| JP2008526771A (ja) * | 2004-12-30 | 2008-07-24 | ジェンザイム コーポレーション | 高リン酸血症のための亜鉛含有処置 |
| CA2620406A1 (fr) * | 2005-09-02 | 2007-03-08 | Genzyme Corporation | Recepteurs moleculaires polymeriques utilises comme sequestrants du phosphate |
| HUE026628T2 (en) | 2005-09-15 | 2016-06-28 | Genzyme Corp | Pouches for amine polymers |
| US20090162314A1 (en) * | 2005-11-08 | 2009-06-25 | Huval Chad C | Magnesium-Containing Polymers for the Treatment of Hyperphosphatemia |
| JP2009542653A (ja) * | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤 |
| BR112012021444A2 (pt) | 2010-02-24 | 2016-05-31 | Relypsa Inc | polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas. |
| RU2612795C2 (ru) | 2010-02-24 | 2017-03-13 | Релипса, Инк. | Аминосодержащие полимеры для применения в качестве секвестрантов желчных кислот |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558581A (en) * | 1967-10-20 | 1971-01-26 | Hoechst Ag | Process for the manufacture of polyvinylmethylamines |
| US4238579A (en) * | 1979-05-18 | 1980-12-09 | Dynapol | Vinylamine aromatic copolymers and salts thereof |
| DE3128478A1 (de) * | 1981-07-18 | 1983-02-03 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von linearen, basischen polymerisaten |
| DE3213873A1 (de) * | 1982-04-15 | 1983-10-27 | Basf Ag, 6700 Ludwigshafen | Flockungsmittel fuer schlaemme |
| FI70230C (fi) * | 1981-07-18 | 1986-09-15 | Basf Ag | Rakkedjiga basiska polymerisat foerfarande foer deras framstaellning och deras anvaendning |
| OA08092A (fr) * | 1984-05-11 | 1987-03-31 | Bristol Myers Co | Novel bile sequestrant resin and uses. |
| DE3534273A1 (de) * | 1985-09-26 | 1987-04-02 | Basf Ag | Verfahren zur herstellung von vinylamin-einheiten enthaltenden wasserloeslichen copolymerisaten und deren verwendung als nass- und trockenverfestigungsmittel fuer papier |
| NL8502882A (nl) * | 1985-10-22 | 1987-05-18 | Stork Friesland Bv | Werkwijze voor de bereiding van een n-vinyl-n-alkilamine (co) polymeer en samengesteld membraan vervaardigd onder toepassing van dit (co) polymeer. |
| CA1330684C (fr) * | 1988-04-15 | 1994-07-12 | Robert Krantz Pinschmidt Jr. | Methode pour la preparation de poly(alcool vinylique)-copoly(vinylamide) par un procede a deux etapes |
| DE3901527A1 (de) * | 1989-01-20 | 1990-07-26 | Hoechst Ag | Alkylierte polyethyleniminderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate |
| DE4007312C2 (de) * | 1990-03-08 | 2000-04-27 | Basf Ag | Verfahren zur Herstellung von feinteiligen, wasserlöslichen, Vinylamin-Einheiten enthaltenden Polymerisaten |
-
1993
- 1993-07-15 DK DK93111376.5T patent/DK0580079T3/da active
- 1993-07-15 ES ES93111376T patent/ES2096150T3/es not_active Expired - Lifetime
- 1993-07-15 DE DE59304725T patent/DE59304725D1/de not_active Expired - Fee Related
- 1993-07-15 EP EP93111376A patent/EP0580079B1/fr not_active Expired - Lifetime
- 1993-07-15 AT AT93111376T patent/ATE146193T1/de not_active IP Right Cessation
- 1993-07-20 NZ NZ248193A patent/NZ248193A/en unknown
- 1993-07-20 FI FI933274A patent/FI933274A/fi unknown
- 1993-07-20 IL IL10642193A patent/IL106421A/en not_active IP Right Cessation
- 1993-07-21 ZA ZA935267A patent/ZA935267B/xx unknown
- 1993-07-21 JP JP5179680A patent/JPH06157671A/ja active Pending
- 1993-07-21 AU AU42089/93A patent/AU659562B2/en not_active Ceased
- 1993-07-21 CA CA002101010A patent/CA2101010A1/fr not_active Abandoned
- 1993-07-21 KR KR1019930013756A patent/KR940005692A/ko not_active Application Discontinuation
- 1993-07-21 NO NO932635A patent/NO301018B1/no not_active IP Right Cessation
- 1993-07-21 US US08/095,624 patent/US5428112A/en not_active Expired - Lifetime
-
1995
- 1995-05-30 US US08/452,797 patent/US5631326A/en not_active Expired - Lifetime
-
1996
- 1996-12-20 GR GR960403573T patent/GR3022135T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL106421A (en) | 1996-11-14 |
| EP0580079A1 (fr) | 1994-01-26 |
| DE59304725D1 (de) | 1997-01-23 |
| NO932635D0 (no) | 1993-07-21 |
| GR3022135T3 (en) | 1997-03-31 |
| NO932635L (no) | 1994-01-24 |
| FI933274A0 (fi) | 1993-07-20 |
| ES2096150T3 (es) | 1997-03-01 |
| US5631326A (en) | 1997-05-20 |
| ATE146193T1 (de) | 1996-12-15 |
| US5428112A (en) | 1995-06-27 |
| FI933274A (fi) | 1994-01-23 |
| DK0580079T3 (da) | 1997-06-30 |
| AU659562B2 (en) | 1995-05-18 |
| NZ248193A (en) | 1995-04-27 |
| ZA935267B (en) | 1994-04-18 |
| JPH06157671A (ja) | 1994-06-07 |
| EP0580079B1 (fr) | 1996-12-11 |
| CA2101010A1 (fr) | 1994-01-23 |
| IL106421A0 (en) | 1993-11-15 |
| KR940005692A (ko) | 1994-03-22 |
| AU4208993A (en) | 1994-01-27 |
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JANUARY 2001 |