NO300732B1 - 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater - Google Patents

1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater Download PDF

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Publication number
NO300732B1
NO300732B1 NO941361A NO941361A NO300732B1 NO 300732 B1 NO300732 B1 NO 300732B1 NO 941361 A NO941361 A NO 941361A NO 941361 A NO941361 A NO 941361A NO 300732 B1 NO300732 B1 NO 300732B1
Authority
NO
Norway
Prior art keywords
indole
methyl
phenylmethyl
amino
oxy
Prior art date
Application number
NO941361A
Other languages
English (en)
Norwegian (no)
Other versions
NO941361L (no
NO941361D0 (no
Inventor
Nicholas James Bach
Robert Delane Dillard
Richard Walter Schevitz
Susan Elizabeth Draheim
Robert Bell Hermann
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO941361D0 publication Critical patent/NO941361D0/no
Publication of NO941361L publication Critical patent/NO941361L/no
Publication of NO300732B1 publication Critical patent/NO300732B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO941361A 1993-04-16 1994-04-15 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater NO300732B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4862993A 1993-04-16 1993-04-16
US20872194A 1994-03-15 1994-03-15

Publications (3)

Publication Number Publication Date
NO941361D0 NO941361D0 (no) 1994-04-15
NO941361L NO941361L (no) 1994-10-17
NO300732B1 true NO300732B1 (no) 1997-07-14

Family

ID=26726342

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941361A NO300732B1 (no) 1993-04-16 1994-04-15 1H-indol-3-acetamid sPLA2-inhibitorer, farmasöytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av farmasöytiske preparater

Country Status (25)

Country Link
US (1) US5684034A (sv)
EP (1) EP0620215B1 (sv)
JP (1) JPH0725850A (sv)
KR (1) KR100317755B1 (sv)
CN (1) CN1068588C (sv)
AT (1) ATE183503T1 (sv)
AU (1) AU676884B2 (sv)
BR (1) BR9401482A (sv)
CA (1) CA2121323A1 (sv)
CO (1) CO4230092A1 (sv)
CZ (1) CZ289750B6 (sv)
DE (1) DE69420068T2 (sv)
DK (1) DK0620215T3 (sv)
ES (1) ES2138648T3 (sv)
FI (1) FI941767A (sv)
GR (1) GR3031783T3 (sv)
HU (1) HUT70836A (sv)
IL (1) IL109311A0 (sv)
NO (1) NO300732B1 (sv)
NZ (1) NZ260298A (sv)
PL (1) PL181319B1 (sv)
RU (1) RU2162463C2 (sv)
TW (1) TW268942B (sv)
UA (1) UA44218C2 (sv)
YU (1) YU20194A (sv)

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IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
US6252084B1 (en) 1994-03-15 2001-06-26 Eli Lilly And Company 1H-indole-3-acetamide sPLA2 inhibitors
KR100368707B1 (ko) * 1994-04-01 2003-06-02 일라이 릴리 앤드 캄파니 1H-인돌-3-글리옥실아미드sPLA2억제제
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
US6214876B1 (en) 1994-07-21 2001-04-10 Eli Lilly And Company Indene-1-acetamide sPLA2 inhibitors
CA2264020A1 (en) * 1996-08-26 1998-03-05 Jean Bemis Inhibitors of phospholipase enzymes
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
YU19299A (sh) * 1996-10-30 2000-03-21 ELI LILLY AND COMPANY, Proizvodno i trgovinsko preduzeće organizovano po propisima države Indiana, US Supstituisani tricikli
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
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US5919774A (en) * 1996-12-10 1999-07-06 Eli Lilly And Company Pyrroles as sPLA2 inhibitors
AU6229298A (en) * 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
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US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
CN1298404A (zh) * 1998-02-25 2001-06-06 遗传研究所有限公司 磷脂酶a2的抑制剂
AU2782699A (en) * 1998-02-25 1999-09-15 Genetics Institute, Llc Inhibitors of phospholipase enzymes
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ID23219A (id) * 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
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KR20010034881A (ko) 1998-05-21 2001-04-25 시오노 요시히코 ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
AU5331499A (en) 1998-08-03 2000-02-28 Eli Lilly And Company Indole spla2 inhibitors
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US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
AU6015600A (en) 1999-07-19 2001-02-05 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
DE60032774D1 (de) * 1999-07-19 2007-02-15 Lilly Co Eli Spla2 inhibitoren
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EP1220839B1 (en) * 1999-09-20 2006-12-06 Eli Lilly And Company Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors
US6831095B1 (en) 1999-09-20 2004-12-14 Eli Lilly And Company Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors
WO2001026653A1 (fr) * 1999-10-15 2001-04-19 Shionogi & Co., Ltd. Inhibiteurs spla2 du type v et/ou du type x
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Also Published As

Publication number Publication date
BR9401482A (pt) 1994-10-18
CZ89394A3 (en) 1994-12-15
EP0620215A1 (en) 1994-10-19
CZ289750B6 (cs) 2002-03-13
CN1068588C (zh) 2001-07-18
CA2121323A1 (en) 1994-10-17
AU676884B2 (en) 1997-03-27
GR3031783T3 (en) 2000-02-29
CN1098715A (zh) 1995-02-15
DE69420068T2 (de) 1999-12-23
CO4230092A1 (es) 1995-10-19
RU2162463C2 (ru) 2001-01-27
NZ260298A (en) 1996-05-28
JPH0725850A (ja) 1995-01-27
KR100317755B1 (ko) 2002-08-09
EP0620215B1 (en) 1999-08-18
YU20194A (sh) 1997-09-30
DE69420068D1 (de) 1999-09-23
DK0620215T3 (da) 1999-12-06
US5684034A (en) 1997-11-04
FI941767A (sv) 1994-10-17
HUT70836A (en) 1995-11-28
UA44218C2 (uk) 2002-02-15
HU9401060D0 (en) 1994-07-28
ATE183503T1 (de) 1999-09-15
TW268942B (sv) 1996-01-21
NO941361L (no) 1994-10-17
IL109311A0 (en) 1994-07-31
FI941767A0 (sv) 1994-04-15
AU5949294A (en) 1994-10-20
PL181319B1 (pl) 2001-07-31
ES2138648T3 (es) 2000-01-16
NO941361D0 (no) 1994-04-15

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