NO2758060T3 - - Google Patents
Info
- Publication number
- NO2758060T3 NO2758060T3 NO12759466A NO12759466A NO2758060T3 NO 2758060 T3 NO2758060 T3 NO 2758060T3 NO 12759466 A NO12759466 A NO 12759466A NO 12759466 A NO12759466 A NO 12759466A NO 2758060 T3 NO2758060 T3 NO 2758060T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11007610 | 2011-09-19 | ||
| EP12759466.1A EP2758060B1 (en) | 2011-09-19 | 2012-09-18 | Ror gamma modulators for treating diabetes ii complications |
| PCT/EP2012/068332 WO2013041519A1 (en) | 2011-09-19 | 2012-09-18 | Ror gamma modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2758060T3 true NO2758060T3 (no) | 2018-04-28 |
Family
ID=46852019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO12759466A NO2758060T3 (no) | 2011-09-19 | 2012-09-18 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9777036B2 (no) |
| EP (1) | EP2758060B1 (no) |
| JP (2) | JP2014526494A (no) |
| KR (1) | KR102020923B1 (no) |
| CN (1) | CN103957919B (no) |
| AU (1) | AU2012311599B2 (no) |
| BR (1) | BR112014003704A2 (no) |
| DK (1) | DK2758060T3 (no) |
| ES (1) | ES2659455T3 (no) |
| NO (1) | NO2758060T3 (no) |
| PL (1) | PL2758060T3 (no) |
| PT (1) | PT2758060T (no) |
| RU (1) | RU2658013C2 (no) |
| WO (1) | WO2013041519A1 (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013169864A2 (en) | 2012-05-08 | 2013-11-14 | Lycera Corporation | TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE |
| MX2014014614A (es) | 2012-05-31 | 2015-02-12 | Phenex Pharmaceuticals Ag | Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huerfano ror [gamma). |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| EP2781217A1 (en) * | 2013-03-18 | 2014-09-24 | ETH Zurich | ROR gamma modulators |
| US9550771B2 (en) * | 2013-09-11 | 2017-01-24 | Genentech, Inc. | Keto-imidazopyridine derivatives as RORc modulators |
| AU2014365915C1 (en) * | 2013-12-19 | 2019-04-04 | Merck Patent Gmbh | Tetrahydro-tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors |
| JP2017507950A (ja) | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
| US10189777B2 (en) | 2014-05-05 | 2019-01-29 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease |
| AU2015256190B2 (en) | 2014-05-05 | 2019-08-15 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| US10421751B2 (en) | 2015-05-05 | 2019-09-24 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| CN107980042B (zh) | 2015-06-11 | 2021-10-08 | 莱斯拉公司 | 用作RORγ激动剂和用于治疗疾病的芳基二氢-2H-苯并[b][1,4]噁嗪磺酰胺和相关化合物 |
| JP7027437B2 (ja) * | 2016-10-27 | 2022-03-01 | エスカリア バイオサイエンシーズ，ビーブイ | ＲＯＲ－γモジュレーター |
| WO2019025029A2 (en) | 2017-08-03 | 2019-02-07 | Vio Chemicals Ag | PROCESS FOR THE PREPARATION OF A BILIARY ACID COMPOUND BY ENZYMATIC CATALYSIS |
| CN109912676B (zh) * | 2019-03-07 | 2021-08-27 | 上海科骊科生物技术有限公司 | 一种3β-熊去氧胆酸的制备方法 |
| WO2022233398A1 (en) | 2021-05-04 | 2022-11-10 | Kostner Pharma Gmbh | COMPOUNDS FOR REDUCING LIPOPROTEIN(a) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07126283A (ja) * | 1993-09-03 | 1995-05-16 | Kunio Tsuji | 胆汁アルコール |
| PT832094E (pt) * | 1995-06-07 | 2004-06-30 | Genaera Corp | Compostos de aminoesterol uteis como inibidores do permutador sodio/protao )nhe) metodos e composicoes farmaceuticas empregando estes inibidores e processos para avaliacao da eficacia inibidora de nhe dos compostos |
| WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| JP2000026300A (ja) | 1998-07-02 | 2000-01-25 | Pola Chem Ind Inc | 血管内皮細胞保護医薬組成物 |
| CA2368234A1 (en) | 1999-03-26 | 2000-10-05 | City Of Hope | Method of affecting cholesterol catabolism using nuclear bile acid receptor |
| EP1218336A2 (en) | 1999-09-20 | 2002-07-03 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| EP1219294A4 (en) | 1999-09-20 | 2005-01-26 | ANTAGONISTS OF THE MELANIN CONCENTRATING HORMON | |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| WO2001056547A2 (en) * | 2000-02-04 | 2001-08-09 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
| MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
| DE60110066T2 (de) | 2000-06-16 | 2006-02-02 | Smithkline Beecham P.L.C., Brentford | Piperidine zur verwendung als orexinrezeptorantagonisten |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| JP4611019B2 (ja) | 2002-06-19 | 2011-01-12 | カロ バイオ エービー | 代謝異常治療のための新規な糖質コルチコイド受容体結合体 |
| WO2006116814A1 (en) * | 2005-05-02 | 2006-11-09 | Vanadis Bioscience Ltd | Composition and uses thereof |
| JP5292310B2 (ja) | 2007-01-19 | 2013-09-18 | インターセプト ファーマシューティカルズ， インコーポレイテッド | Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法 |
| WO2009011420A1 (ja) * | 2007-07-18 | 2009-01-22 | Mitsubishi Tanabe Pharma Corporation | ２型糖尿病の治療薬 |
| CA2716922C (en) * | 2008-02-26 | 2016-06-28 | British Columbia Cancer Agency Branch | Polyhydroxylated bile acids for treatment of biliary disorders |
| CN102712672B (zh) * | 2009-08-25 | 2016-09-14 | 胆清医药有限公司 | 用于治疗胆疾病的多羟基化胆汁酸 |
-
2012
- 2012-09-18 NO NO12759466A patent/NO2758060T3/no unknown
- 2012-09-18 EP EP12759466.1A patent/EP2758060B1/en active Active
- 2012-09-18 PL PL12759466T patent/PL2758060T3/pl unknown
- 2012-09-18 WO PCT/EP2012/068332 patent/WO2013041519A1/en active Application Filing
- 2012-09-18 DK DK12759466.1T patent/DK2758060T3/en active
- 2012-09-18 CN CN201280045611.7A patent/CN103957919B/zh not_active Expired - Fee Related
- 2012-09-18 AU AU2012311599A patent/AU2012311599B2/en not_active Ceased
- 2012-09-18 PT PT127594661T patent/PT2758060T/pt unknown
- 2012-09-18 ES ES12759466.1T patent/ES2659455T3/es active Active
- 2012-09-18 KR KR1020147010403A patent/KR102020923B1/ko active IP Right Grant
- 2012-09-18 US US14/345,597 patent/US9777036B2/en active Active
- 2012-09-18 JP JP2014530269A patent/JP2014526494A/ja active Pending
- 2012-09-18 BR BR112014003704A patent/BR112014003704A2/pt not_active Application Discontinuation
- 2012-09-18 RU RU2014115796A patent/RU2658013C2/ru not_active IP Right Cessation
-
2017
- 2017-07-28 JP JP2017146926A patent/JP6439206B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140079416A (ko) | 2014-06-26 |
| CN103957919B (zh) | 2018-10-16 |
| CN103957919A (zh) | 2014-07-30 |
| EP2758060B1 (en) | 2017-11-29 |
| BR112014003704A2 (pt) | 2017-03-07 |
| AU2012311599A1 (en) | 2014-02-20 |
| JP2014526494A (ja) | 2014-10-06 |
| WO2013041519A9 (en) | 2013-06-27 |
| KR102020923B1 (ko) | 2019-09-11 |
| RU2658013C2 (ru) | 2018-06-19 |
| JP2018024651A (ja) | 2018-02-15 |
| JP6439206B2 (ja) | 2018-12-19 |
| PT2758060T (pt) | 2018-01-24 |
| US9777036B2 (en) | 2017-10-03 |
| RU2014115796A (ru) | 2015-10-27 |
| PL2758060T3 (pl) | 2018-04-30 |
| AU2012311599B2 (en) | 2017-07-06 |
| EP2758060A1 (en) | 2014-07-30 |
| DK2758060T3 (en) | 2018-03-05 |
| NZ620485A (en) | 2016-04-29 |
| ES2659455T3 (es) | 2018-03-15 |
| WO2013041519A1 (en) | 2013-03-28 |
| US20140343023A1 (en) | 2014-11-20 |