NO20090135L - Polymorfer av N-hydroksy-3-[4-[[[-(2-metyl-1H-indol-3-yl)etyl]amino]metyl]fenyl]2E-2-propenamid - Google Patents

Polymorfer av N-hydroksy-3-[4-[[[-(2-metyl-1H-indol-3-yl)etyl]amino]metyl]fenyl]2E-2-propenamid

Info

Publication number
NO20090135L
NO20090135L NO20090135A NO20090135A NO20090135L NO 20090135 L NO20090135 L NO 20090135L NO 20090135 A NO20090135 A NO 20090135A NO 20090135 A NO20090135 A NO 20090135A NO 20090135 L NO20090135 L NO 20090135L
Authority
NO
Norway
Prior art keywords
methyl
indol
hydroxy
phenyl
ethyl
Prior art date
Application number
NO20090135A
Other languages
English (en)
Norwegian (no)
Inventor
Joel Slade
Piotr Karpinski
Dimitris Papoutsakis
Joginder S Bajwa
Frank Stowasser
Murat Acemoglu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832679&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20090135(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20090135L publication Critical patent/NO20090135L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
NO20090135A 2006-06-12 2009-01-09 Polymorfer av N-hydroksy-3-[4-[[[-(2-metyl-1H-indol-3-yl)etyl]amino]metyl]fenyl]2E-2-propenamid NO20090135L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80451706P 2006-06-12 2006-06-12
US88322407P 2007-01-03 2007-01-03
PCT/US2007/070561 WO2007146716A2 (fr) 2006-06-12 2007-06-07 Polymorphes de n-hydroxy-3-[4-[[[2-(2-méthyl-1h-indol-3-yl)éthyl]amino]méthyl]phényl]-2e-2-propénamide

Publications (1)

Publication Number Publication Date
NO20090135L true NO20090135L (no) 2009-03-12

Family

ID=38832679

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090135A NO20090135L (no) 2006-06-12 2009-01-09 Polymorfer av N-hydroksy-3-[4-[[[-(2-metyl-1H-indol-3-yl)etyl]amino]metyl]fenyl]2E-2-propenamid

Country Status (29)

Country Link
US (1) US7989494B2 (fr)
EP (2) EP2086930A2 (fr)
JP (3) JP2009540006A (fr)
KR (4) KR20090015968A (fr)
CN (1) CN102584673B (fr)
AR (1) AR061297A1 (fr)
AU (1) AU2007257881B2 (fr)
BR (1) BRPI0712993A2 (fr)
CA (1) CA2650263A1 (fr)
CL (1) CL2007001689A1 (fr)
CR (1) CR10440A (fr)
EA (1) EA017984B1 (fr)
EC (1) ECSP088976A (fr)
GE (1) GEP20115175B (fr)
GT (1) GT200800280A (fr)
IL (1) IL195015A (fr)
MA (1) MA30511B1 (fr)
ME (1) ME00529B (fr)
MX (1) MX2008015900A (fr)
MY (1) MY149337A (fr)
NI (1) NI200800306A (fr)
NO (1) NO20090135L (fr)
PE (1) PE20080852A1 (fr)
PH (1) PH12012501725A1 (fr)
SM (1) SMP200900001B (fr)
TN (1) TNSN08495A1 (fr)
TW (2) TWI453196B (fr)
UY (1) UY30406A1 (fr)
WO (1) WO2007146716A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2032531T3 (pl) * 2006-06-12 2016-07-29 Novartis Ag Sole N-hydroksy-3-[4-[[[2-(2-metylo-1H-indol-3-ilo)etylo]amino]metylo]fenylo]-2E-2-propenoamidu
EP2117598A2 (fr) * 2007-01-10 2009-11-18 Novartis AG Formulations d'inhibiteurs de la déacétylase
WO2017032281A1 (fr) * 2015-08-21 2017-03-02 苏州晶云药物科技有限公司 Nouvelles formes cristallines de lactate de panobinostat
CN106866492B (zh) * 2015-12-10 2021-11-26 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ii及其制备方法和用途
CN106866491B (zh) * 2015-12-10 2021-12-10 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ⅰ及其制备方法和用途
WO2018092151A1 (fr) * 2016-11-21 2018-05-24 Msn Laboratories Private Limited, R&D Center Procédé de préparation de l'acide 2- (e)-n-hydroxy-3-[4- [[ [2- (2-méthyl -1 h-indol-3-yl) éthyl] amino] méthyl] phényl]-2-propénamide 2-hydroxypropanoïque (1 : 1) et ses polymorphes
WO2018163114A1 (fr) * 2017-03-10 2018-09-13 Shilpa Medicare Limited Panobinostat amorphe et son sel de lactate
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
KR20220050886A (ko) * 2019-08-20 2022-04-25 오노 야꾸힝 고교 가부시키가이샤 S1p5 수용체 작동 활성을 갖는 화합물의 염 및 결정형
GB201913122D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913121D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913124D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
ATE352319T1 (de) * 2001-11-06 2007-02-15 Novartis Pharma Gmbh Kombination cyclooxygenase-2 inhibitor/ histone deacetylase inhibitor
EP1456664A1 (fr) 2001-12-07 2004-09-15 Novartis AG Utilisation des niveaux d'acetylation d'alpha-tubuline en tant que biomarqueur d'inhibiteurs de deacetylase proteique
BRPI0410648A (pt) 2003-05-21 2006-07-04 Novartis Ag combinação de inibidores de histona desacetilase com agentes quimioterápicos
WO2005013958A1 (fr) 2003-08-07 2005-02-17 Novartis Ag Inhibiteurs d'histone deacetylase utilises comme immunosuppresseurs
JP2007505938A (ja) 2003-09-23 2007-03-15 ノバルティス アクチエンゲゼルシャフト Ｖｅｇｆ受容体阻害剤と化学療法剤の組み合わせ
PL2032531T3 (pl) 2006-06-12 2016-07-29 Novartis Ag Sole N-hydroksy-3-[4-[[[2-(2-metylo-1H-indol-3-ilo)etylo]amino]metylo]fenylo]-2E-2-propenoamidu

Also Published As

Publication number Publication date
GT200800280A (es) 2015-11-24
CN102584673A (zh) 2012-07-18
TW201441190A (zh) 2014-11-01
UY30406A1 (es) 2008-01-31
KR20090015968A (ko) 2009-02-12
NI200800306A (es) 2012-02-01
CA2650263A1 (fr) 2007-12-21
EP2409967A1 (fr) 2012-01-25
SMAP200900001A (it) 2009-01-14
TWI453196B (zh) 2014-09-21
CL2007001689A1 (es) 2008-05-16
PE20080852A1 (es) 2008-08-19
WO2007146716A3 (fr) 2009-07-30
IL195015A (en) 2014-03-31
JP2015164968A (ja) 2015-09-17
MA30511B1 (fr) 2009-06-01
EA200802383A1 (ru) 2010-02-26
EA017984B1 (ru) 2013-04-30
CN102584673B (zh) 2014-08-06
CR10440A (es) 2011-08-22
JP2013139476A (ja) 2013-07-18
ME00529B (fr) 2011-10-10
US7989494B2 (en) 2011-08-02
KR20150082690A (ko) 2015-07-15
AR061297A1 (es) 2008-08-20
ECSP088976A (es) 2009-01-30
AU2007257881B2 (en) 2011-06-16
SMP200900001B (it) 2010-03-01
BRPI0712993A2 (pt) 2012-04-17
JP2009540006A (ja) 2009-11-19
EP2086930A2 (fr) 2009-08-12
KR20160032264A (ko) 2016-03-23
IL195015A0 (en) 2009-08-03
US20090192210A1 (en) 2009-07-30
MX2008015900A (es) 2009-03-06
GEP20115175B (en) 2011-03-10
MY149337A (en) 2013-08-30
WO2007146716A2 (fr) 2007-12-21
AU2007257881A1 (en) 2007-12-21
TW200815344A (en) 2008-04-01
TWI515179B (zh) 2016-01-01
TNSN08495A1 (en) 2010-04-14
PH12012501725A1 (en) 2015-07-06
KR20140142335A (ko) 2014-12-11

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