NO20085062L - Fermentativ produksjon av lipstatin - Google Patents

Fermentativ produksjon av lipstatin

Info

Publication number
NO20085062L
NO20085062L NO20085062A NO20085062A NO20085062L NO 20085062 L NO20085062 L NO 20085062L NO 20085062 A NO20085062 A NO 20085062A NO 20085062 A NO20085062 A NO 20085062A NO 20085062 L NO20085062 L NO 20085062L
Authority
NO
Norway
Prior art keywords
lipstatin
production
fermentative production
present
obesity
Prior art date
Application number
NO20085062A
Other languages
English (en)
Inventor
Ales Gasparic
Gordan Sladic
Neda Benicki Svagelj
Mitja Pelko
Peter Raspor
Hrvoje Petkovic
Stefan Fujs
Original Assignee
Krka Tovarna Zdravil Dd Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil Dd Novo Mesto filed Critical Krka Tovarna Zdravil Dd Novo Mesto
Publication of NO20085062L publication Critical patent/NO20085062L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse angår fremstilling av sekundære metabolitter og særlig fremstilling av lipstatin. Lipstatin, en potent inhibitor av pancreas lipase, er rapportert å være anvendelig ved behandling og/eller hindring av fedme og relaterte sykdommer. Foreliggende oppfinnelse beskriver en fremgangsmåte som muliggjør fremstilling av nevnte enzyminhibitor i høye utbytter og høy renhet.
NO20085062A 2006-05-22 2008-12-04 Fermentativ produksjon av lipstatin NO20085062L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06010470A EP1860194A1 (en) 2006-05-22 2006-05-22 Fermentative production of lipstatin
PCT/EP2007/004529 WO2007134836A1 (en) 2006-05-22 2007-05-22 Fermentative production of lipstatin

Publications (1)

Publication Number Publication Date
NO20085062L true NO20085062L (no) 2009-02-16

Family

ID=37037452

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085062A NO20085062L (no) 2006-05-22 2008-12-04 Fermentativ produksjon av lipstatin

Country Status (9)

Country Link
EP (2) EP1860194A1 (no)
AT (1) ATE500339T1 (no)
DE (1) DE602007012862D1 (no)
EA (1) EA014192B1 (no)
NO (1) NO20085062L (no)
PL (1) PL2019869T3 (no)
SI (1) SI2019869T1 (no)
UA (1) UA93552C2 (no)
WO (1) WO2007134836A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2719581C (en) * 2008-03-26 2013-11-12 Biocon Limited Improved fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid
EP2141236A1 (en) 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Process for production of lipstatin and microorganisms therefore
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN102827892A (zh) * 2012-09-05 2012-12-19 李海霞 一种尼泊司他汀生产工艺
CN103468603B (zh) * 2013-07-17 2015-02-11 杭州华东医药集团新药研究院有限公司 一种毒三素链霉菌及其在制备利普司他汀中的应用
CN105063118A (zh) * 2015-07-19 2015-11-18 聊城大学 一种添加亚油酸缓释微囊提高利普斯他汀发酵单位的方法
CN105061365A (zh) * 2015-07-20 2015-11-18 聊城大学 一锅法从发酵液中提取利普司他汀的方法
CN106868070A (zh) * 2017-04-14 2017-06-20 孟怡杉 一种微生物发酵生产利普司他汀的培养基
CN108753861B (zh) * 2018-06-08 2022-02-01 福建省微生物研究所 一种毒三素链霉菌发酵产利普司他汀的培养基及方法
CN115851553B (zh) * 2022-12-30 2024-04-26 西南大学 一种可防治根肿病的弗吉尼亚链霉菌及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY116591A (en) * 1996-04-26 2004-02-28 Hoffmann La Roche Process for the production of lipstatin and tetrahydrolipstatin
US6844174B2 (en) * 2001-12-04 2005-01-18 Biogal Gyogyszergyar Rt. Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth

Also Published As

Publication number Publication date
DE602007012862D1 (de) 2011-04-14
EP2019869A1 (en) 2009-02-04
ATE500339T1 (de) 2011-03-15
EP2019869B1 (en) 2011-03-02
EA200802175A1 (ru) 2009-04-28
UA93552C2 (en) 2011-02-25
WO2007134836A1 (en) 2007-11-29
EP1860194A1 (en) 2007-11-28
EA014192B1 (ru) 2010-10-29
SI2019869T1 (sl) 2011-07-29
PL2019869T3 (pl) 2011-07-29

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application