ATE500339T1 - Fermentative produktion von lipstatin - Google Patents

Fermentative produktion von lipstatin

Info

Publication number
ATE500339T1
ATE500339T1 AT07725429T AT07725429T ATE500339T1 AT E500339 T1 ATE500339 T1 AT E500339T1 AT 07725429 T AT07725429 T AT 07725429T AT 07725429 T AT07725429 T AT 07725429T AT E500339 T1 ATE500339 T1 AT E500339T1
Authority
AT
Austria
Prior art keywords
lipstatin
production
fermentative production
present
obesity
Prior art date
Application number
AT07725429T
Other languages
English (en)
Inventor
Ales Gasparic
Gordan Sladic
Svagelj Neda Benicki
Mitja Pelko
Peter Raspor
Hrvoje Petkovic
Stefan Fujs
Original Assignee
Krka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka filed Critical Krka
Application granted granted Critical
Publication of ATE500339T1 publication Critical patent/ATE500339T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT07725429T 2006-05-22 2007-05-22 Fermentative produktion von lipstatin ATE500339T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06010470A EP1860194A1 (de) 2006-05-22 2006-05-22 Fermentative Herstellung von Lipstatin
PCT/EP2007/004529 WO2007134836A1 (en) 2006-05-22 2007-05-22 Fermentative production of lipstatin

Publications (1)

Publication Number Publication Date
ATE500339T1 true ATE500339T1 (de) 2011-03-15

Family

ID=37037452

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07725429T ATE500339T1 (de) 2006-05-22 2007-05-22 Fermentative produktion von lipstatin

Country Status (9)

Country Link
EP (2) EP1860194A1 (de)
AT (1) ATE500339T1 (de)
DE (1) DE602007012862D1 (de)
EA (1) EA014192B1 (de)
NO (1) NO20085062L (de)
PL (1) PL2019869T3 (de)
SI (1) SI2019869T1 (de)
UA (1) UA93552C2 (de)
WO (1) WO2007134836A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2755736T3 (es) * 2008-03-26 2020-04-23 Biocon Ltd Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido
EP2141236A1 (de) * 2008-07-03 2010-01-06 KRKA, D.D., Novo Mesto Verfahren zur Herstellung von Lipstatin und Mikroorganismen dafür
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN102827892A (zh) * 2012-09-05 2012-12-19 李海霞 一种尼泊司他汀生产工艺
CN103468603B (zh) * 2013-07-17 2015-02-11 杭州华东医药集团新药研究院有限公司 一种毒三素链霉菌及其在制备利普司他汀中的应用
CN105063118A (zh) * 2015-07-19 2015-11-18 聊城大学 一种添加亚油酸缓释微囊提高利普斯他汀发酵单位的方法
CN105061365A (zh) * 2015-07-20 2015-11-18 聊城大学 一锅法从发酵液中提取利普司他汀的方法
CN106868070A (zh) * 2017-04-14 2017-06-20 孟怡杉 一种微生物发酵生产利普司他汀的培养基
CN108753861B (zh) * 2018-06-08 2022-02-01 福建省微生物研究所 一种毒三素链霉菌发酵产利普司他汀的培养基及方法
CN115851553B (zh) * 2022-12-30 2024-04-26 西南大学 一种可防治根肿病的弗吉尼亚链霉菌及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY116591A (en) * 1996-04-26 2004-02-28 Hoffmann La Roche Process for the production of lipstatin and tetrahydrolipstatin
EP1458882A2 (de) * 2001-12-04 2004-09-22 Biogal Gyogyszergyar Rt. Fermentationsverfahren für lipstatin und verfahren zur extraktion von lipstatin aus einer fermentationsbrühe

Also Published As

Publication number Publication date
EA200802175A1 (ru) 2009-04-28
EP1860194A1 (de) 2007-11-28
EP2019869A1 (de) 2009-02-04
EA014192B1 (ru) 2010-10-29
WO2007134836A1 (en) 2007-11-29
UA93552C2 (en) 2011-02-25
NO20085062L (no) 2009-02-16
PL2019869T3 (pl) 2011-07-29
DE602007012862D1 (de) 2011-04-14
SI2019869T1 (sl) 2011-07-29
EP2019869B1 (de) 2011-03-02

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