NO20083717L - Pyrrolotriazin-anilin prodrugforbindelser anvendbare som kinaseinhibitorer - Google Patents

Pyrrolotriazin-anilin prodrugforbindelser anvendbare som kinaseinhibitorer

Info

Publication number
NO20083717L
NO20083717L NO20083717A NO20083717A NO20083717L NO 20083717 L NO20083717 L NO 20083717L NO 20083717 A NO20083717 A NO 20083717A NO 20083717 A NO20083717 A NO 20083717A NO 20083717 L NO20083717 L NO 20083717L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
pyrrolotriazine
aniline
prodrugs useful
useful
Prior art date
Application number
NO20083717A
Other languages
English (en)
Norwegian (no)
Inventor
Katerina Leftheris
Vivekananda M Vrudhula
James Lin
Chunjian Liu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20083717L publication Critical patent/NO20083717L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
NO20083717A 2006-03-07 2008-08-29 Pyrrolotriazin-anilin prodrugforbindelser anvendbare som kinaseinhibitorer NO20083717L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07
PCT/US2007/063250 WO2007103839A2 (en) 2006-03-07 2007-03-05 Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20083717L true NO20083717L (no) 2008-10-06

Family

ID=38475749

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083717A NO20083717L (no) 2006-03-07 2008-08-29 Pyrrolotriazin-anilin prodrugforbindelser anvendbare som kinaseinhibitorer

Country Status (17)

Country Link
US (2) US7572795B2 (zh)
EP (1) EP2001886A2 (zh)
JP (1) JP2009535295A (zh)
KR (1) KR20080107408A (zh)
CN (1) CN101395158A (zh)
AR (1) AR059778A1 (zh)
AU (1) AU2007223342A1 (zh)
BR (1) BRPI0708644A2 (zh)
CA (1) CA2645031A1 (zh)
EA (1) EA200801945A1 (zh)
IL (1) IL193653A0 (zh)
MX (1) MX2008011136A (zh)
NO (1) NO20083717L (zh)
PE (1) PE20080139A1 (zh)
TW (1) TW200804390A (zh)
WO (1) WO2007103839A2 (zh)
ZA (1) ZA200807459B (zh)

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WO2009158450A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof
WO2009158446A2 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof
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AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
JP5732453B2 (ja) * 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
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CN102596921B (zh) * 2009-09-29 2015-04-29 葛兰素集团有限公司 新化合物
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WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
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US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
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JP2016534133A (ja) 2013-09-06 2016-11-04 ゼノポート，インコーポレイティド （ｎ，ｎ−ジエチルカルバモイル）メチル メチル（２ｅ）ブト−２−エン−１，４−ジオエートの結晶形態、その合成方法及び使用
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MA41136A (fr) * 2014-12-09 2017-10-17 Bayer Pharma AG Composés pour le traitement d'un cancer
WO2017070135A1 (en) * 2015-10-20 2017-04-27 Bristol-Myers Squibb Company Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer
NZ747259A (en) 2016-04-04 2022-11-25 Chemocentryx Inc Soluble c5ar antagonists
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN114748622A (zh) 2017-10-05 2022-07-15 弗尔康医疗公司 P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd
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EP2001886A2 (en) 2008-12-17
EA200801945A1 (ru) 2009-02-27
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KR20080107408A (ko) 2008-12-10
BRPI0708644A2 (pt) 2011-06-07
AU2007223342A1 (en) 2007-09-13
CN101395158A (zh) 2009-03-25
AR059778A1 (es) 2008-04-30
IL193653A0 (en) 2009-08-03
WO2007103839A3 (en) 2008-06-05
TW200804390A (en) 2008-01-16
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US20090156555A1 (en) 2009-06-18
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