NO20081787L - Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet - Google Patents

Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

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Publication number
NO20081787L
NO20081787L NO20081787A NO20081787A NO20081787L NO 20081787 L NO20081787 L NO 20081787L NO 20081787 A NO20081787 A NO 20081787A NO 20081787 A NO20081787 A NO 20081787A NO 20081787 L NO20081787 L NO 20081787L
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group
hydrogen atom
new
binding activity
receptor binding
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NO20081787A
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English (en)
Inventor
Mamoru Matsuda
Toshiyuki Mori
Kenji Kawashima
Masato Nagatsuka
Sachiko Kobayashi
Minoru Yamamoto
Masatomo Kato
Miwa Takai
Tomoko Oda
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Santen Pharmaceutical Co Inc
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Publication of NO20081787L publication Critical patent/NO20081787L/no

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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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Abstract

En syntese av nye 1,2-dihydrokinolinderivater og deres farmakologiske virkning. En forbindelse representert ved den generelle formel (1) eller et salt derav er effektiv når det gjelder behandling av en glukokortikoid reseptorrelatert sykdom. I formelen betyr ring X betyr en benzenring eller en pyridinring; R1 betyr et halogenatom, en alkylgruppe, en hydroksygruppe, en alkoksygruppe, en aminogruppe eller lignende; p betyr et helt tall fra 0 til 5; R2 betyr et halogenatom, en alkylgruppe, en hydroksygruppe eller lignende; q betyr et helt tall fra 0 til 2; R3 betyr et hydrogenatom, en alkylgruppe, en alkenylgruppe eller lignende; R4 og R5 representerer et hydrogenatom eller lignende; R6 betyr et hydrogenatom eller lignende; A betyr en alkylengruppe eller lignende og R7 betyr OR8, NR8R9, SR8, S(0)R8 eller S(0)2R8, hvori R8 betyr en arylgruppe, en heterosyklisk gruppe eller lignende og R9 betyr et hydrogenatom eller lignende.
NO20081787A 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet NO20081787L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005266622 2005-09-14
JP2006027128 2006-02-03
PCT/JP2006/318674 WO2007032556A1 (ja) 2005-09-14 2006-09-14 グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体

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NO20081787L true NO20081787L (no) 2008-06-10

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NO20081787A NO20081787L (no) 2005-09-14 2008-04-11 Nye 1-3-dihydrokinolinderivat som har glukocorticosteroid-reseptorbindingsaktivitet

Country Status (13)

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US (2) US8017775B2 (no)
EP (1) EP1944290B1 (no)
KR (1) KR101390094B1 (no)
CN (4) CN102304124B (no)
AU (1) AU2006289751A1 (no)
BR (1) BRPI0615892A2 (no)
CA (1) CA2621292C (no)
ES (1) ES2455142T3 (no)
HK (2) HK1165800A1 (no)
NO (1) NO20081787L (no)
PL (1) PL1944290T3 (no)
RU (1) RU2008114369A (no)
WO (1) WO2007032556A1 (no)

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CN102304124B (zh) 2005-09-14 2014-10-22 参天制药株式会社 具有糖皮质激素受体结合活性的1,2-二氢喹啉衍生物
MX2008011779A (es) 2006-03-14 2008-09-25 Santen Pharma Co Ltd Derivado novedoso de 1,2,3,4-tetrahidroquinoxalina con actividad de union de receptor glucocorticoide.
RU2485104C2 (ru) 2006-11-14 2013-06-20 Сантен Фармасьютикал Ко., Лтд. Новые производные 1,2-дигидрохинолина, обладающие активностью связывания глюкокортикоидного рецептора
WO2008111632A1 (ja) * 2007-03-13 2008-09-18 Santen Pharmaceutical Co., Ltd. ２，２，４－トリメチル－６－フェニル－１，２－ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト
WO2008146871A1 (ja) * 2007-05-29 2008-12-04 Santen Pharmaceutical Co., Ltd. グルココルチコイド受容体結合活性を有する、スルホン酸エステル又はスルホン酸アミド構造を導入したフェニル基を置換基として有する新規１，２，３，４－テトラヒドロキノキサリン誘導体
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
WO2009035067A1 (ja) * 2007-09-13 2009-03-19 Santen Pharmaceutical Co., Ltd. １，３，３－トリメチル－７－フェニル－３，４－ジヒドロ－１ｈ－キノキサリン－２－オン誘導体からなるグルココルチコイド受容体アゴニスト
WO2009035068A1 (ja) * 2007-09-13 2009-03-19 Santen Pharmaceutical Co., Ltd. 新規１，３，３－トリメチル－７－フェニル－３，４－ジヒドロ－１ｈ－キノキサリン－２－オン誘導体
CA2724055C (en) * 2008-05-12 2016-08-02 Santen Pharmaceutical Co., Ltd. Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2 -dihydroquinoline derivatives having substituted oxy group
US8664221B2 (en) * 2008-09-12 2014-03-04 Santen Pharmaceutical Co., Ltd. Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
KR20140002735A (ko) 2011-02-09 2014-01-08 산텐 세이야꾸 가부시키가이샤 3-히드록시-6H-벤조[c]크로멘-6-온 유도체 및 그 제조 방법
US20120316199A1 (en) 2011-06-07 2012-12-13 Ward Keith W Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
TW201343638A (zh) * 2012-01-20 2013-11-01 參天製藥股份有限公司 １，２－二氫喹啉衍生物或其鹽的工業製造方法及其製造中間體
RU2644944C1 (ru) * 2017-04-06 2018-02-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Способ получения (Z)-этил 2-(4-(4-хлорфенил)-2,4-диоксо-3-(3-оксо-3,4-дигидрохиноксалин-2(1Н)-илиден)бутанамидо)-4-метил-5-фенилтиофен-3-карбоксилата
AU2018283250B2 (en) 2017-06-16 2022-09-01 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
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CN102229562A (zh) 2011-11-02
PL1944290T3 (pl) 2014-07-31
HK1166072A1 (en) 2012-10-19
US20090326009A1 (en) 2009-12-31
CA2621292C (en) 2014-05-27
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EP1944290A1 (en) 2008-07-16
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AU2006289751A1 (en) 2007-03-22
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CA2621292A1 (en) 2007-03-22
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CN102311385A (zh) 2012-01-11
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