NO20081523L - Fremstilling og anvendelse av tetrahydropyrrolo(3,2-C)Pyridin-4-on-derivater for behandling av fedme, psykiatriske og neurologiske forstyrrelser - Google Patents

Fremstilling og anvendelse av tetrahydropyrrolo(3,2-C)Pyridin-4-on-derivater for behandling av fedme, psykiatriske og neurologiske forstyrrelser

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Publication number
NO20081523L
NO20081523L NO20081523A NO20081523A NO20081523L NO 20081523 L NO20081523 L NO 20081523L NO 20081523 A NO20081523 A NO 20081523A NO 20081523 A NO20081523 A NO 20081523A NO 20081523 L NO20081523 L NO 20081523L
Authority
NO
Norway
Prior art keywords
pyridin
tetrahydropyrrolo
psychiatric
obesity
preparation
Prior art date
Application number
NO20081523A
Other languages
English (en)
Inventor
Leifeng Cheng
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37781800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081523(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20081523L publication Critical patent/NO20081523L/no

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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Foreliggende oppfinnelse angår 4,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-on- og 4,5-dihydropyrrolo[3,2-c]pyridin-4-on-forbindelser med formel I og fremgangsmåter for fremstilling av slike forbindelser, anvendelse av dem ved behandling av fedme, psykiatriske og nevrologiske lidelser, metoder for deres terapeutiske anvendelse og farmasøytiske preparater inneholdende dem.
NO20081523A 2005-10-06 2008-03-28 Fremstilling og anvendelse av tetrahydropyrrolo(3,2-C)Pyridin-4-on-derivater for behandling av fedme, psykiatriske og neurologiske forstyrrelser NO20081523L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72415605P 2005-10-06 2005-10-06
PCT/GB2006/003695 WO2007039740A2 (en) 2005-10-06 2006-10-05 Preparation and use of tetrahydropyrrolo [3, 2-c] pyridin-4-one derivatives for treatment of obesity, psychiatric and neurological disorders

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NO20081523L true NO20081523L (no) 2008-07-02

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NO20081523A NO20081523L (no) 2005-10-06 2008-03-28 Fremstilling og anvendelse av tetrahydropyrrolo(3,2-C)Pyridin-4-on-derivater for behandling av fedme, psykiatriske og neurologiske forstyrrelser

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US (2) US7875626B2 (no)
EP (1) EP1937679B1 (no)
JP (1) JP4277062B2 (no)
KR (1) KR20080058456A (no)
CN (1) CN101277957A (no)
AR (1) AR056560A1 (no)
AT (1) ATE440099T1 (no)
AU (1) AU2006298530B2 (no)
BR (1) BRPI0616653A2 (no)
CA (1) CA2624495A1 (no)
DE (1) DE602006008641D1 (no)
EC (1) ECSP088413A (no)
ES (1) ES2329616T3 (no)
HK (1) HK1122808A1 (no)
IL (1) IL190025A0 (no)
NO (1) NO20081523L (no)
RU (1) RU2415856C2 (no)
TW (1) TW200730525A (no)
UY (1) UY29838A1 (no)
WO (1) WO2007039740A2 (no)
ZA (1) ZA200802946B (no)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1
PT1973910E (pt) * 2006-01-27 2013-09-06 Shanghai Hengrui Pharm Co Ltd Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
AR065909A1 (es) * 2007-04-03 2009-07-08 Astrazeneca Ab Agentes terapeuticos 685
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GEP20125664B (en) * 2008-02-26 2012-10-10 Takeda Pharmaceuticals Co Condensed heterocyclic derivatives and application thereof
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
CA2771278A1 (en) 2009-08-26 2011-03-03 Sanofi Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
KR101273643B1 (ko) * 2010-10-12 2013-06-11 한국화학연구원 5,6-디하이드로-피롤로[3,4-b]피리딘-7-온 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US9560630B2 (en) * 2011-08-12 2017-01-31 Qualcomm Incorporated Devices for reduced overhead paging
UY35370A (es) 2013-03-06 2014-09-30 Janssen Pharmaceutica Nv Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4
UA122221C2 (uk) 2015-01-28 2020-10-12 Байєр Фарма Акцієнгезелльшафт 4Н-ПІРОЛО[3,2-c]ПІРИДИН-4-ОНОВІ ПОХІДНІ
WO2020074403A1 (en) * 2018-10-08 2020-04-16 Universität Zürich Appetite-modulating molecules
US20230046077A1 (en) 2019-02-07 2023-02-16 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors
US20210015762A1 (en) * 2019-07-16 2021-01-21 TRUETIVA, Inc. Compositions for treating obesity
KR20210103688A (ko) 2020-02-14 2021-08-24 (주) 디엔테크 오링용 고무조성물
EP4188929A1 (en) 2020-07-29 2023-06-07 Bayer Aktiengesellschaft Substituted pyrrolo-pyridinone derivatives and therapeutic uses thereof
EP4188551A1 (en) 2020-07-29 2023-06-07 Bayer Aktiengesellschaft Aryl substituted pyrrolo-pyridinones and therapeutic uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US6858616B2 (en) * 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
UA74367C2 (uk) 2000-03-23 2005-12-15 Сольве Фармас'Ютікалз Б.В. ПОХІДНІ 4,5-ДИГІДРО-1Н-ПІРАЗОЛУ, ЩО ВИЯВЛЯЮТЬ АНТАГОНІСТИЧНУ АКТИВНІСТЬ ЩОДО СВ<sub>1</sub>, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЇЇ ВИГОТОВЛЕННЯ, СПОСІБ ЛІКУВАННЯ ЗАХВОРЮВАНЬ (ВАРІАНТИ)
MXPA04002249A (es) * 2001-09-24 2004-06-29 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de 1,5,6,7,-tetrahidro-pirrolo[3,2-c]piridina para el tratamiento de la obesidad.
CA2555331C (en) 2004-02-20 2011-01-04 Astrazeneca Ab Therapeutic agents
GB0403780D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Therapeutic agents
CA2560417C (en) 2004-04-03 2011-04-19 Astrazeneca Ab 1,2-diarylimidazole-4-carboxamide derivatives
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1

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