NO20080487L - Rekominant interferona2 (IFNa2) mutanter - Google Patents
Rekominant interferona2 (IFNa2) mutanterInfo
- Publication number
- NO20080487L NO20080487L NO20080487A NO20080487A NO20080487L NO 20080487 L NO20080487 L NO 20080487L NO 20080487 A NO20080487 A NO 20080487A NO 20080487 A NO20080487 A NO 20080487A NO 20080487 L NO20080487 L NO 20080487L
- Authority
- NO
- Norway
- Prior art keywords
- ifnα2
- mutants
- present
- ifna2
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SAMMENDRAG Den foreliggende oppfinnelsen tilveiebringer IFNa2-mutanter og aktive fragmenter, analoger, derivater og varianter av disse som har bedret spesifikk agonist- eller antagonistaktivitet sammenlignet med villtype IFNa2. Den foreliggende oppfinnelsen tilveiebringer videre farmasøytiske sammensetninger som omfatter IFNa2-mutanter som kan brukes for å behandle eller forebygge kreft, autoimmune sykdommer, infeksjonssykdommer eller lidelser assosiert med forhøyet ekspresjon av IFNa2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69481005P | 2005-06-29 | 2005-06-29 | |
PCT/IL2006/000754 WO2007000769A2 (en) | 2005-06-29 | 2006-06-28 | RECOMBINANT INTERFERON α2 (IFNα2) MUTANTS |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080487L true NO20080487L (no) | 2008-03-28 |
Family
ID=37595529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080487A NO20080487L (no) | 2005-06-29 | 2008-01-25 | Rekominant interferona2 (IFNa2) mutanter |
Country Status (12)
Country | Link |
---|---|
US (2) | US7767799B2 (no) |
EP (2) | EP2476428B1 (no) |
JP (1) | JP5208733B2 (no) |
CN (1) | CN101304758B (no) |
AU (1) | AU2006263331B2 (no) |
BR (1) | BRPI0613098A2 (no) |
CA (1) | CA2613737C (no) |
EA (1) | EA014157B1 (no) |
ES (2) | ES2435846T3 (no) |
HK (1) | HK1125317A1 (no) |
NO (1) | NO20080487L (no) |
WO (1) | WO2007000769A2 (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008124086A2 (en) * | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
KR101759460B1 (ko) | 2007-09-21 | 2017-07-18 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 표적화된 인터페론이 강력한 아폽토시스 및 항-종양 활성을 발휘함 |
WO2010030671A1 (en) * | 2008-09-09 | 2010-03-18 | University Of Medicine And Dentistry Of New Jersey | Type i interferon antagonists |
US20120014911A1 (en) * | 2009-01-09 | 2012-01-19 | Serge Fuchs | Regulators of the Interferon-Alpha Receptor 1 (IFNAR1) Chain of the Interferon Receptor |
EA201700111A1 (ru) * | 2011-10-28 | 2018-02-28 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидные конструкции и их применение |
CN102584956B (zh) * | 2012-02-13 | 2014-09-17 | 中山大学 | 一种慢性乙型病毒性肝炎相关基因ifna2的新突变蛋白、编码基因及其应用 |
CN102532299B (zh) * | 2012-02-23 | 2013-07-17 | 北京三元基因工程有限公司 | 干扰素α突变体及其聚乙二醇衍生物 |
CN102532300B (zh) * | 2012-02-23 | 2013-07-17 | 北京三元基因工程有限公司 | 干扰素α突变体及其聚乙二醇衍生物 |
CN104470536A (zh) | 2012-03-03 | 2015-03-25 | 免疫基因公司 | 工程化的抗体-干扰素突变体融合分子 |
US9803021B2 (en) | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
US20150366944A1 (en) | 2013-02-20 | 2015-12-24 | Yeda Research And Development Co. Ltd. | Interferon treatment targeting mutant p53 expressing cells |
PL2992013T3 (pl) | 2013-04-29 | 2020-09-07 | Teva Pharmaceuticals Australia Pty Ltd | Przeciwciała anty-cd38 i fuzje z atenuowanym interferonem alfa-2b |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
WO2014194100A1 (en) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Anti-cspg4 fusions with interferon for the treatment of malignancy |
SG11201600165WA (en) * | 2013-07-19 | 2016-02-26 | Vib Vzw | Targeting of cytokine antagonists |
WO2015168474A1 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
US10544199B2 (en) | 2014-10-29 | 2020-01-28 | Teva Pharmaceuticals Australia Pty Ltd | Interferon alpha 2B variants |
CN107556376B (zh) * | 2017-09-08 | 2018-09-28 | 上海华新生物高技术有限公司 | 一种干扰素α-2b突变体及其制备方法和应用 |
CN108117595B (zh) * | 2018-02-28 | 2020-06-26 | 中国科学院微生物研究所 | 一种犬α干扰素的制备及其应用 |
CN108752457B (zh) * | 2018-05-23 | 2019-06-21 | 华中农业大学 | 一种来源于草鱼干扰素的衍生多肽及其应用 |
CN108997489B (zh) * | 2018-09-04 | 2021-08-27 | 中国药科大学 | 干扰素突变体及干扰素突变体融合抗体及其制备方法、应用 |
CN110437328B (zh) * | 2019-08-22 | 2021-06-04 | 安阳工学院 | 一种猪干扰素α突变体YNS及其制备方法和应用 |
AR117715A1 (es) * | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
RU2741570C1 (ru) * | 2019-12-26 | 2021-01-27 | Генетик Диагностикс Энд Терапи 21 Лтд | Генотерапевтический ДНК-вектор на основе генотерапевтического ДНК-вектора GDTT1.8NAS12, несущий целевой ген, выбранный из группы генов IFNB1, IFNA14, IFNA2, IL12A, IL12B для повышения уровня экспрессии этих целевых генов, способ его получения и применения, штамм Escherichia coli JM110-NAS/GDTT1.8NAS12-IFNB1, или Escherichia coli JM110-NAS/GDTT1.8NAS12-IFNA14, или Escherichia coli JM110-NAS/GDTT1.8NAS12-IFNA2, или Escherichia coli JM110-NAS/GDTT1.8NAS12-IL12A, или Escherichia coli JM110-NAS/GDTT1.8NAS12-IL12B, несущий генотерапевтический ДНК-вектор, способ его получения, способ производства в промышленных масштабах генотерапевтического ДНК-вектора |
CN113440603B (zh) * | 2020-03-26 | 2022-07-08 | 复旦大学 | 人α干扰素亚型及受体结合相关位点突变体在制备防治新型冠状病毒感染药物中的用途 |
WO2023230231A1 (en) * | 2022-05-25 | 2023-11-30 | Malcolm Thomas | Controlled expression of therapeutically relevant biomolecules for lumen-localized payloads in biomimetic nanovesicles and exosomes |
US20240067691A1 (en) | 2022-08-18 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Interferon receptor agonists and uses thereof |
WO2024040247A1 (en) | 2022-08-18 | 2024-02-22 | Regeneron Pharmaceuticals, Inc. | Interferon proproteins and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
ATE144149T1 (de) | 1991-08-30 | 1996-11-15 | Genentech Inc | Therapeutisches verfahren zur behandlung von iddm |
US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
TW249202B (no) * | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
DK0859630T3 (da) | 1995-10-04 | 2003-03-24 | Schering Corp | Kombination af termozolomid og alfa-IFN til behandling af fremskreden cancer |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
WO1999003887A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US20040002474A1 (en) | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
DE60120917T2 (de) | 2000-01-26 | 2007-01-25 | Schering Corp. | Kombinationspräparat zur krebstherapie |
US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
JP5424521B2 (ja) * | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | アルブミン融合タンパク質 |
AU2003267700A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
WO2004031352A2 (en) * | 2002-10-01 | 2004-04-15 | Xencor, Inc. | Interferon variants with improved properties |
AU2004213565A1 (en) | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
US20050008616A1 (en) | 2003-07-11 | 2005-01-13 | Schering Aktiengesellschaft | Recombinant human interferon-beta-1b polypeptides |
EP1789074A4 (en) | 2004-08-09 | 2009-08-12 | Alios Biopharma Inc | PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME |
-
2006
- 2006-06-28 EP EP12154308.6A patent/EP2476428B1/en active Active
- 2006-06-28 US US11/994,159 patent/US7767799B2/en not_active Expired - Fee Related
- 2006-06-28 EP EP06756232.2A patent/EP1909822B1/en active Active
- 2006-06-28 CN CN2006800306398A patent/CN101304758B/zh not_active Expired - Fee Related
- 2006-06-28 BR BRPI0613098-4A patent/BRPI0613098A2/pt not_active IP Right Cessation
- 2006-06-28 ES ES12154308T patent/ES2435846T3/es active Active
- 2006-06-28 EA EA200800159A patent/EA014157B1/ru not_active IP Right Cessation
- 2006-06-28 WO PCT/IL2006/000754 patent/WO2007000769A2/en active Application Filing
- 2006-06-28 AU AU2006263331A patent/AU2006263331B2/en not_active Ceased
- 2006-06-28 ES ES06756232.2T patent/ES2436761T3/es active Active
- 2006-06-28 CA CA2613737A patent/CA2613737C/en not_active Expired - Fee Related
- 2006-06-28 JP JP2008519136A patent/JP5208733B2/ja not_active Expired - Fee Related
-
2008
- 2008-01-04 US US11/969,319 patent/US7919078B2/en not_active Expired - Fee Related
- 2008-01-25 NO NO20080487A patent/NO20080487L/no not_active Application Discontinuation
-
2009
- 2009-05-11 HK HK09104314.2A patent/HK1125317A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2435846T3 (es) | 2013-12-23 |
US20080166319A1 (en) | 2008-07-10 |
EP1909822A2 (en) | 2008-04-16 |
EP2476428A1 (en) | 2012-07-18 |
EP2476428B1 (en) | 2013-08-21 |
WO2007000769A3 (en) | 2009-05-22 |
CA2613737C (en) | 2017-05-23 |
JP5208733B2 (ja) | 2013-06-12 |
EA200800159A1 (ru) | 2008-10-30 |
CN101304758B (zh) | 2013-08-21 |
ES2436761T3 (es) | 2014-01-07 |
US20080279823A1 (en) | 2008-11-13 |
AU2006263331A1 (en) | 2007-01-04 |
US7767799B2 (en) | 2010-08-03 |
EP1909822B1 (en) | 2013-09-25 |
HK1125317A1 (en) | 2009-08-07 |
EA014157B1 (ru) | 2010-10-29 |
EP1909822A4 (en) | 2009-12-02 |
JP2009501514A (ja) | 2009-01-22 |
AU2006263331B2 (en) | 2012-02-16 |
CA2613737A1 (en) | 2007-01-04 |
US7919078B2 (en) | 2011-04-05 |
CN101304758A (zh) | 2008-11-12 |
BRPI0613098A2 (pt) | 2010-12-21 |
WO2007000769A2 (en) | 2007-01-04 |
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