NO20080176L - PARP-modulatorer og behandling av kreft - Google Patents

PARP-modulatorer og behandling av kreft

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Publication number
NO20080176L
NO20080176L NO20080176A NO20080176A NO20080176L NO 20080176 L NO20080176 L NO 20080176L NO 20080176 A NO20080176 A NO 20080176A NO 20080176 A NO20080176 A NO 20080176A NO 20080176 L NO20080176 L NO 20080176L
Authority
NO
Norway
Prior art keywords
parp
activity
aromatic compound
organic aromatic
mammal
Prior art date
Application number
NO20080176A
Other languages
English (en)
Inventor
Ernest Kun
Jerome Mendeleyev
Pal Bauer
Original Assignee
Bipar Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bipar Sciences Inc filed Critical Bipar Sciences Inc
Publication of NO20080176L publication Critical patent/NO20080176L/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/10—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring unsubstituted
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
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  • Communicable Diseases (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
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Abstract

Foreliggende oppfinnelse angår en fremgangsmåte for modulering av poly(ADP-ribose)polymerase-l (PARP-I) aktivitet hos et pattedyr som innbefatter administrering til et pattedyr en effektiv mengde av en organisk aromatisk forbindelse som har fra 4 til ca. 35 karbonatomer, hvori nevnte organiske aromatiske forbindelse er i stand til å binde arginin-34 bestanddelen lokalisert i Sink finger-1 til PARP-I enzymet og hvori nevnte organiske aromatiske forbindelse har elektrondonerende evner slik at dens 7r-elektron system vil reagere innbyrdes med den positivt ladede (kationiske) guanidinium bestanddelen til det spesifikke arginin-34 residuet til Sink-1 fingeren til PARP-I og ikke inneholder benzamid- eller laktamsubstituenter. Spesielt er substituerte benzopyroner og substituerte indoler og deres farmasøytiske sammensetninger som inneholder slike forbindelser som modulerer aktiviteten til PARP-I beskrevet. Oppfinnelsen angår også materialsammensetning, kits og fremgangsmåter for deres terapeutiske og/eller propylaktiske anvendelse ved behandling av sykdommer og forstyrrelser beskrevet heri, ved å administrere effektive mengder av slike forbindelser. Foretrukket inhiberer sammensetningene og fremgangsmåtene tilveiebrakt heri PARP aktivitet.
NO20080176A 2005-06-10 2008-01-10 PARP-modulatorer og behandling av kreft NO20080176L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68917805P 2005-06-10 2005-06-10
PCT/US2006/022907 WO2006135873A2 (en) 2005-06-10 2006-06-12 Parp modulators and treatment of cancer

Publications (1)

Publication Number Publication Date
NO20080176L true NO20080176L (no) 2008-03-10

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Family Applications (1)

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NO20080176A NO20080176L (no) 2005-06-10 2008-01-10 PARP-modulatorer og behandling av kreft

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US (2) US20070015814A1 (no)
EP (1) EP1904468A4 (no)
JP (1) JP2008543786A (no)
KR (1) KR20080031266A (no)
CN (1) CN101233121A (no)
AU (1) AU2006257815A1 (no)
BR (1) BRPI0611814A2 (no)
CA (1) CA2612979A1 (no)
IL (1) IL187898A0 (no)
MX (1) MX2007015479A (no)
NO (1) NO20080176L (no)
RU (1) RU2008100017A (no)
WO (1) WO2006135873A2 (no)

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EP1904468A2 (en) 2008-04-02
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IL187898A0 (en) 2008-03-20
BRPI0611814A2 (pt) 2008-12-09
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