NO20076478L - Substituerte oksadiazolderivater som positive allosteriske modulatorer av metabotrope glutamatreseptorer - Google Patents
Substituerte oksadiazolderivater som positive allosteriske modulatorer av metabotrope glutamatreseptorerInfo
- Publication number
- NO20076478L NO20076478L NO20076478A NO20076478A NO20076478L NO 20076478 L NO20076478 L NO 20076478L NO 20076478 A NO20076478 A NO 20076478A NO 20076478 A NO20076478 A NO 20076478A NO 20076478 L NO20076478 L NO 20076478L
- Authority
- NO
- Norway
- Prior art keywords
- oxadiazole derivatives
- metabotropic glutamate
- positive allosteric
- glutamate receptors
- allosteric modulators
- Prior art date
Links
- 150000004866 oxadiazoles Chemical class 0.000 title abstract 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 1
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0510138A GB0510138D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds A4 |
| GBGB0601709.9A GB0601709D0 (en) | 2006-01-27 | 2006-01-27 | Novel compounds A4 |
| PCT/IB2006/001881 WO2006123255A2 (en) | 2005-05-18 | 2006-05-17 | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20076478L true NO20076478L (no) | 2008-01-28 |
Family
ID=37431638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20076478A NO20076478L (no) | 2005-05-18 | 2007-12-17 | Substituerte oksadiazolderivater som positive allosteriske modulatorer av metabotrope glutamatreseptorer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090215822A1 (enExample) |
| EP (1) | EP1893606A2 (enExample) |
| JP (1) | JP2008540635A (enExample) |
| KR (1) | KR20080027463A (enExample) |
| AU (1) | AU2006248655A1 (enExample) |
| BR (1) | BRPI0611423A2 (enExample) |
| CA (1) | CA2608014A1 (enExample) |
| EA (1) | EA015813B1 (enExample) |
| IL (1) | IL187186A0 (enExample) |
| MX (1) | MX2007014444A (enExample) |
| NO (1) | NO20076478L (enExample) |
| NZ (1) | NZ564254A (enExample) |
| WO (1) | WO2006123255A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| TW200911255A (en) | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
| TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
| US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| EP2421370A4 (en) * | 2009-04-23 | 2012-12-12 | Merck Sharp & Dohme | 2-alkyl-piperidine-mGluR5 receptor MODULATORS |
| US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| US20130210804A1 (en) * | 2010-10-25 | 2013-08-15 | Neville J. Anthony | Tricyclic mglur5 receptor modulators |
| WO2016065584A1 (en) * | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| JP6668329B2 (ja) | 2015-03-25 | 2020-03-18 | 国立研究開発法人国立長寿医療研究センター | 新規オキサジアゾール誘導体及びこれを含有する医薬 |
| WO2022069953A1 (en) * | 2020-09-29 | 2022-04-07 | Ranjith Siddaraj | Synthesis and characterization of (s)-3-(5- fluoropyridin-2-yl)-5-(piperidin-3-yl)-l,2,4-oxadiazole derivatives and their secretory phospholipase a2 (spla2) inhibitor activity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966748A (en) * | 1975-05-08 | 1976-06-29 | American Cyanamid Company | Para-fluorophenyl-N-heterocyclic substituted butanes |
| NZ538339A (en) * | 2002-08-09 | 2007-01-26 | Astrazeneca Ab | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| AU2004225887A1 (en) * | 2003-04-03 | 2004-10-14 | Merck & Co., Inc. | 4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 |
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| SG149900A1 (en) * | 2004-02-18 | 2009-02-27 | Astrazeneca Ab | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
| GB0510143D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
-
2006
- 2006-05-17 AU AU2006248655A patent/AU2006248655A1/en not_active Abandoned
- 2006-05-17 KR KR1020077029359A patent/KR20080027463A/ko not_active Ceased
- 2006-05-17 US US11/920,603 patent/US20090215822A1/en not_active Abandoned
- 2006-05-17 WO PCT/IB2006/001881 patent/WO2006123255A2/en not_active Ceased
- 2006-05-17 EP EP06779843A patent/EP1893606A2/en not_active Withdrawn
- 2006-05-17 CA CA002608014A patent/CA2608014A1/en not_active Abandoned
- 2006-05-17 EA EA200702469A patent/EA015813B1/ru not_active IP Right Cessation
- 2006-05-17 BR BRPI0611423-7A patent/BRPI0611423A2/pt not_active IP Right Cessation
- 2006-05-17 NZ NZ564254A patent/NZ564254A/en not_active IP Right Cessation
- 2006-05-17 JP JP2008511821A patent/JP2008540635A/ja active Pending
- 2006-05-17 MX MX2007014444A patent/MX2007014444A/es not_active Application Discontinuation
-
2007
- 2007-11-06 IL IL187186A patent/IL187186A0/en unknown
- 2007-12-17 NO NO20076478A patent/NO20076478L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540635A (ja) | 2008-11-20 |
| KR20080027463A (ko) | 2008-03-27 |
| AU2006248655A1 (en) | 2006-11-23 |
| NZ564254A (en) | 2011-04-29 |
| MX2007014444A (es) | 2008-04-21 |
| EP1893606A2 (en) | 2008-03-05 |
| BRPI0611423A2 (pt) | 2010-09-08 |
| EA200702469A1 (ru) | 2008-06-30 |
| WO2006123255A3 (en) | 2007-03-29 |
| IL187186A0 (en) | 2008-02-09 |
| EA015813B1 (ru) | 2011-12-30 |
| CA2608014A1 (en) | 2006-11-23 |
| US20090215822A1 (en) | 2009-08-27 |
| WO2006123255A2 (en) | 2006-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20076478L (no) | Substituerte oksadiazolderivater som positive allosteriske modulatorer av metabotrope glutamatreseptorer | |
| NO20076479L (no) | Nye oksadiazolderivater og anvendelse derav som positive allosteriske metabotropiske modulatorer av glutamatreseptorer | |
| NO20076477L (no) | Nye heterosykliske forbindelser som positive allosteriske modulatorer av metabotrope glutamatreseptorer | |
| EA200702470A1 (ru) | Производные пиррола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
| NO20074275L (no) | 2- (4-okso-4H-kinazolin-3-yl) acetamider og deres anvendelse som Vasopressin-V3-antagonister | |
| NO20063599L (no) | Ytterligere heterosykliske forbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister | |
| NO20070606L (no) | Inhibitorer av IAP | |
| NO20073663L (no) | Tiazol-4-karboksamid-derivater som mGluR5 antagonister | |
| NO20082346L (no) | Hydrazonderivater og anvendelser derav | |
| EA201070143A1 (ru) | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов | |
| EA201000050A1 (ru) | Замещенные бициклолактамные соединения | |
| NO20091553L (no) | Fenylderivater og deres anvendelse som immunmodulatorer | |
| ATE493397T1 (de) | Neuartige tetrazolderivate als positive allosterische modulatoren von metabotropen glutamatrezeptoren | |
| EA200870521A1 (ru) | Замещенные спироциклические антагонисты cgrp-рецепторов | |
| NO20070249L (no) | Pyrrazolo-pyrimidin derivater | |
| NO20090202L (no) | Prolylhydroksylaseinhibitorer | |
| NO20092286L (no) | Nitrogenhaldige heterosykliske forbindelser og anvendelse derav | |
| NO20081217L (no) | Nye benzotiazolonderivater | |
| NO20083584L (no) | Bensoyl-piperidin derivater som 5HT2/D3 modulatorer | |
| WO2008036652A3 (en) | Amidines as modulators of indoleamine 2,3-dioxygenase | |
| NO20082096L (no) | Azaindol-2-karboksamidderivativer | |
| NO20080394L (no) | N-(arylalkyl)-1H-pyrrolopyridin-2-karboksamidderivater, fremstilling og anvendelse derav | |
| NO20076145L (no) | Ureadeviater, fremgangsmater for deres fremstilling og anvendelse derav | |
| ATE430744T1 (de) | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren | |
| NO20082214L (no) | 1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |