EA015813B1 - Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов - Google Patents
Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов Download PDFInfo
- Publication number
- EA015813B1 EA015813B1 EA200702469A EA200702469A EA015813B1 EA 015813 B1 EA015813 B1 EA 015813B1 EA 200702469 A EA200702469 A EA 200702469A EA 200702469 A EA200702469 A EA 200702469A EA 015813 B1 EA015813 B1 EA 015813B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxadiazol
- piperidin
- methanone
- disorder
- fluorophenyl
- Prior art date
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0510138A GB0510138D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds A4 |
| GBGB0601709.9A GB0601709D0 (en) | 2006-01-27 | 2006-01-27 | Novel compounds A4 |
| PCT/IB2006/001881 WO2006123255A2 (en) | 2005-05-18 | 2006-05-17 | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200702469A1 EA200702469A1 (ru) | 2008-06-30 |
| EA015813B1 true EA015813B1 (ru) | 2011-12-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702469A EA015813B1 (ru) | 2005-05-18 | 2006-05-17 | Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
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| Country | Link |
|---|---|
| US (1) | US20090215822A1 (enExample) |
| EP (1) | EP1893606A2 (enExample) |
| JP (1) | JP2008540635A (enExample) |
| KR (1) | KR20080027463A (enExample) |
| AU (1) | AU2006248655A1 (enExample) |
| BR (1) | BRPI0611423A2 (enExample) |
| CA (1) | CA2608014A1 (enExample) |
| EA (1) | EA015813B1 (enExample) |
| IL (1) | IL187186A0 (enExample) |
| MX (1) | MX2007014444A (enExample) |
| NO (1) | NO20076478L (enExample) |
| NZ (1) | NZ564254A (enExample) |
| WO (1) | WO2006123255A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
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| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| TW200911255A (en) | 2007-06-07 | 2009-03-16 | Astrazeneca Ab | Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators-841 |
| TWI417100B (zh) * | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途 |
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| US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| EP2421370A4 (en) * | 2009-04-23 | 2012-12-12 | Merck Sharp & Dohme | 2-alkyl-piperidine-mGluR5 receptor MODULATORS |
| US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| US20130210804A1 (en) * | 2010-10-25 | 2013-08-15 | Neville J. Anthony | Tricyclic mglur5 receptor modulators |
| WO2016065584A1 (en) * | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| JP6668329B2 (ja) | 2015-03-25 | 2020-03-18 | 国立研究開発法人国立長寿医療研究センター | 新規オキサジアゾール誘導体及びこれを含有する医薬 |
| WO2022069953A1 (en) * | 2020-09-29 | 2022-04-07 | Ranjith Siddaraj | Synthesis and characterization of (s)-3-(5- fluoropyridin-2-yl)-5-(piperidin-3-yl)-l,2,4-oxadiazole derivatives and their secretory phospholipase a2 (spla2) inhibitor activity |
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| WO2004014370A2 (en) * | 2002-08-09 | 2004-02-19 | Astrazeneca Ab | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| WO2004087653A2 (en) * | 2003-04-03 | 2004-10-14 | Merck & Co., Inc. | 4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 |
| WO2005044797A1 (en) * | 2003-11-06 | 2005-05-19 | Addex Pharmaceuticals Sa | Allosteric modulators of metabotropic glutamate receptors |
| WO2005080386A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
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| US3966748A (en) * | 1975-05-08 | 1976-06-29 | American Cyanamid Company | Para-fluorophenyl-N-heterocyclic substituted butanes |
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| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
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| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
-
2006
- 2006-05-17 AU AU2006248655A patent/AU2006248655A1/en not_active Abandoned
- 2006-05-17 KR KR1020077029359A patent/KR20080027463A/ko not_active Ceased
- 2006-05-17 US US11/920,603 patent/US20090215822A1/en not_active Abandoned
- 2006-05-17 WO PCT/IB2006/001881 patent/WO2006123255A2/en not_active Ceased
- 2006-05-17 EP EP06779843A patent/EP1893606A2/en not_active Withdrawn
- 2006-05-17 CA CA002608014A patent/CA2608014A1/en not_active Abandoned
- 2006-05-17 EA EA200702469A patent/EA015813B1/ru not_active IP Right Cessation
- 2006-05-17 BR BRPI0611423-7A patent/BRPI0611423A2/pt not_active IP Right Cessation
- 2006-05-17 NZ NZ564254A patent/NZ564254A/en not_active IP Right Cessation
- 2006-05-17 JP JP2008511821A patent/JP2008540635A/ja active Pending
- 2006-05-17 MX MX2007014444A patent/MX2007014444A/es not_active Application Discontinuation
-
2007
- 2007-11-06 IL IL187186A patent/IL187186A0/en unknown
- 2007-12-17 NO NO20076478A patent/NO20076478L/no not_active Application Discontinuation
Patent Citations (4)
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| WO2004014370A2 (en) * | 2002-08-09 | 2004-02-19 | Astrazeneca Ab | Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| WO2004087653A2 (en) * | 2003-04-03 | 2004-10-14 | Merck & Co., Inc. | 4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5 |
| WO2005044797A1 (en) * | 2003-11-06 | 2005-05-19 | Addex Pharmaceuticals Sa | Allosteric modulators of metabotropic glutamate receptors |
| WO2005080386A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540635A (ja) | 2008-11-20 |
| KR20080027463A (ko) | 2008-03-27 |
| AU2006248655A1 (en) | 2006-11-23 |
| NZ564254A (en) | 2011-04-29 |
| MX2007014444A (es) | 2008-04-21 |
| EP1893606A2 (en) | 2008-03-05 |
| BRPI0611423A2 (pt) | 2010-09-08 |
| EA200702469A1 (ru) | 2008-06-30 |
| NO20076478L (no) | 2008-01-28 |
| WO2006123255A3 (en) | 2007-03-29 |
| IL187186A0 (en) | 2008-02-09 |
| CA2608014A1 (en) | 2006-11-23 |
| US20090215822A1 (en) | 2009-08-27 |
| WO2006123255A2 (en) | 2006-11-23 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |