NO20076464L - Motilidforbindelser - Google Patents

Motilidforbindelser

Info

Publication number
NO20076464L
NO20076464L NO20076464A NO20076464A NO20076464L NO 20076464 L NO20076464 L NO 20076464L NO 20076464 A NO20076464 A NO 20076464A NO 20076464 A NO20076464 A NO 20076464A NO 20076464 L NO20076464 L NO 20076464L
Authority
NO
Norway
Prior art keywords
motilidforbindelser
compounds
useful
formula
structure according
Prior art date
Application number
NO20076464A
Other languages
English (en)
Inventor
Yaoquan Liu
Christopher Carreras
David C Myles
Yong Li
Simon James Shaw
Hong Fu
Yue Chen
Hao Zheng
Yandong Li
Mark A Burlingame
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20076464L publication Critical patent/NO20076464L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Forbindelser som har en struktur i henhold til formel (I) hvor RA, RB, Rc, RD, RE og RF er som definert heri, er anvendelige som prokinetiske midler.
NO20076464A 2005-05-24 2007-12-14 Motilidforbindelser NO20076464L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68461205P 2005-05-24 2005-05-24
US71540605P 2005-09-08 2005-09-08
US74889805P 2005-12-08 2005-12-08
US11/416,519 US7582611B2 (en) 2005-05-24 2006-05-02 Motilide compounds
PCT/US2006/017672 WO2006127252A1 (en) 2005-05-24 2006-05-08 Motilide compounds

Publications (1)

Publication Number Publication Date
NO20076464L true NO20076464L (no) 2008-02-22

Family

ID=37452327

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076464A NO20076464L (no) 2005-05-24 2007-12-14 Motilidforbindelser

Country Status (20)

Country Link
US (1) US7582611B2 (no)
EP (1) EP1888082B1 (no)
JP (1) JP4197359B2 (no)
KR (1) KR100956465B1 (no)
AP (1) AP2337A (no)
AU (1) AU2006249555B2 (no)
BR (1) BRPI0611374A2 (no)
CA (1) CA2609494C (no)
CU (1) CU23750B7 (no)
EA (1) EA014711B1 (no)
ES (1) ES2392860T3 (no)
GE (1) GEP20094854B (no)
HK (1) HK1117739A1 (no)
IL (1) IL186752A (no)
MA (1) MA29485B1 (no)
MX (1) MX2007014255A (no)
NO (1) NO20076464L (no)
NZ (1) NZ562891A (no)
TN (1) TNSN07436A1 (no)
WO (1) WO2006127252A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2632779A1 (en) * 2005-12-08 2007-06-14 Pfizer Inc. Method for demethylating the 3'-dimethylamino group of erythromycin compounds
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
EP2104680B1 (en) 2006-12-05 2013-01-09 Bristol-Myers Squibb Company Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
RU2533116C2 (ru) 2009-02-27 2014-11-20 Раквалиа Фарма Инк. Оксииндольные производные, обладающие агонистической активностью в отношении мотилинового рецептора
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU35369B (en) 1973-01-19 1980-12-31 Pliva Zagreb Process for preparing n-(benzenesulfonyl)-erythromycilamine derivatives
US3983103A (en) 1973-01-19 1976-09-28 Pliva Pharmaceutical And Chemical Works N-(Benzenesulfonyl)-erythromycylamine derivatives
US3855200A (en) 1973-04-23 1974-12-17 Polska Akademia Nauk Instytut Process for preparing 8-hydroxyerthromycin a and intermediates therefor
YU35363B (en) 1974-01-14 1980-12-31 Pliva Zagreb Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
IT1196041B (it) 1984-03-08 1988-11-10 Pierrel Spa Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
JPS60218321A (ja) 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
US5175150A (en) 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US5008249A (en) 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DE69211845T2 (de) 1991-04-09 1997-01-23 Abbott Lab Macrozyklische laktam-prokinetika
US5523418A (en) 1991-04-09 1996-06-04 Abbott Laboratories Macrocyclic lactam prokinetic agents
DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
KR0179379B1 (ko) 1992-01-21 1999-04-01 찰스 엠.브록 4"-데옥시에리트로마이신 유도체
US5470961A (en) 1992-03-19 1995-11-28 Takeda Chemical Ind., Ltd. 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives
MY113693A (en) 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
ZA966601B (en) 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
EP0918783A1 (en) 1996-05-07 1999-06-02 Abbott Laboratories 6-o-substituted erythromycins and method for making them
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
NZ333861A (en) * 1996-07-05 2000-08-25 Pfizer Erythromycins and preparation from unnatural starter units in microorganisms
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
US5922849A (en) 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
US6169168B1 (en) 1997-10-29 2001-01-02 Taisho Pharmaceuticals Co., Ltd. Erythromycin A derivatives
US6084079A (en) 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
IT1306205B1 (it) * 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP1255763A2 (en) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Motilide compounds
US6897299B2 (en) * 2000-09-01 2005-05-24 Chugai Seiyaku Kabushiki Kaisha Process for producing erythromycin derivative
US20020094962A1 (en) 2000-12-01 2002-07-18 Gary Ashley Motilide compounds
JP2002241391A (ja) 2001-02-15 2002-08-28 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
AU2002247141A1 (en) 2001-02-15 2002-08-28 Kosan Biosciences, Inc. Method for evaluating therapeutic efficacy
SI1532131T1 (sl) 2002-08-29 2009-04-30 Pfizer Motilidne spojine
US20050113319A1 (en) 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
JP2007509980A (ja) 2003-10-30 2007-04-19 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
US7211568B2 (en) 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
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Also Published As

Publication number Publication date
AP2337A (en) 2011-12-14
ES2392860T3 (es) 2012-12-14
AU2006249555A8 (en) 2006-11-30
AU2006249555B2 (en) 2009-07-16
US7582611B2 (en) 2009-09-01
CU20070261A7 (es) 2009-07-16
NZ562891A (en) 2011-01-28
WO2006127252A1 (en) 2006-11-30
KR100956465B1 (ko) 2010-05-07
GEP20094854B (en) 2009-12-10
EP1888082A4 (en) 2008-12-17
EP1888082B1 (en) 2012-09-12
JP4197359B2 (ja) 2008-12-17
CA2609494A1 (en) 2006-11-30
AP2007004220A0 (en) 2007-10-31
CA2609494C (en) 2010-12-21
JP2008542268A (ja) 2008-11-27
MA29485B1 (fr) 2008-05-02
KR20080013922A (ko) 2008-02-13
HK1117739A1 (en) 2009-01-23
US20060270616A1 (en) 2006-11-30
TNSN07436A1 (fr) 2009-03-17
BRPI0611374A2 (pt) 2010-08-31
IL186752A (en) 2011-10-31
EA014711B1 (ru) 2011-02-28
MX2007014255A (es) 2008-01-22
IL186752A0 (en) 2008-02-09
EA200702290A1 (ru) 2008-04-28
EP1888082A1 (en) 2008-02-20
AU2006249555A1 (en) 2006-11-30
CU23750B7 (es) 2012-01-31

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Legal Events

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