NO20074929L - Influensa terapeutisk middel - Google Patents

Influensa terapeutisk middel

Info

Publication number
NO20074929L
NO20074929L NO20074929A NO20074929A NO20074929L NO 20074929 L NO20074929 L NO 20074929L NO 20074929 A NO20074929 A NO 20074929A NO 20074929 A NO20074929 A NO 20074929A NO 20074929 L NO20074929 L NO 20074929L
Authority
NO
Norway
Prior art keywords
rnai
influenza
inducing
influenza virus
provides
Prior art date
Application number
NO20074929A
Other languages
English (en)
Inventor
Jianzhu Chen
Herman N Eisen
Qing Ge
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/102,097 external-priority patent/US20060160759A1/en
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of NO20074929L publication Critical patent/NO20074929L/no

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SAMMENDRAG Foreliggende oppfinnelse tilveiebringe r blandinger omfattende en RNAi-induserende enhet målrettet mot et influensavirus-transkript og hvilke som helst av en rekke midler for levering. Oppfinnelsen omfatter videre fremgangsmåter for anvendelse av blandingene for å hemme en biologisk aktivitet av et influensavirus og/eller for behandling eller forebygging av influensa. Oppfinnelsen tilveiebringer mål-andel sekvenser som er fordelaktig konservert for RNAi gjennom en rekke influensavirus A-stammer isolert fra humane verter og/eller fugle-verter og RNAi-induserende enheter, f.eks. siRNA'er og shRNA'er, målrettet mot slike fordelaktig konserverte mål-andeler. Oppfinnelsen tilveiebringer en rekke nukleinsyrer omfattende sekvenser identiske eller komplementære til minst en del av én eller flere av disse fordelaktig konserverte mål-andel-sekvensene. Oppfinnelsen tilveiebringer videre fremgangsmåter og blandinger for levering av RNAi-induserende midler til et organ eller vev av et mammalsk subjekt, f.eks. til lungen. Fremgangsmåter for diagnostisering av influensa og bestemmelse av følsomheten av et influensavirus for hemming ved et RNAi-induserende middel tilveiebringes også. Transgene dyr som uttrykker et RNAi-induserende middel målrettet mot et influensa-gen er et annet aspekt ved oppfinnelsen.
NO20074929A 2005-03-22 2007-09-28 Influensa terapeutisk middel NO20074929L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66458005P 2005-03-22 2005-03-22
US11/102,097 US20060160759A1 (en) 2002-09-28 2005-04-08 Influenza therapeutic
PCT/US2006/010491 WO2006102461A2 (en) 2005-03-22 2006-03-22 Influenza therapeutic

Publications (1)

Publication Number Publication Date
NO20074929L true NO20074929L (no) 2007-12-18

Family

ID=39406020

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074929A NO20074929L (no) 2005-03-22 2007-09-28 Influensa terapeutisk middel

Country Status (5)

Country Link
JP (1) JP2008533990A (no)
CN (1) CN101180395A (no)
IL (1) IL186057A0 (no)
MX (1) MX2007011665A (no)
NO (1) NO20074929L (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103966213A (zh) * 2013-02-06 2014-08-06 霍晋 A型流感病毒M基因有干扰作用的siRNA序列的设计和干扰作用的鉴定
CN103966212A (zh) * 2013-02-06 2014-08-06 霍晋 A型流感病毒NP基因有干扰作用的siRNA序列的设计及应用
CN103966214A (zh) * 2013-02-06 2014-08-06 霍晋 A型流感病毒PB基因有干扰作用的siRNA序列的设计及应用
CA2915842C (en) * 2013-06-17 2022-11-29 The Broad Institute, Inc. Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
CN112410275A (zh) * 2014-01-23 2021-02-26 科罗拉多州立大学研究基金会 流感的大肠杆菌介导的siRNA沉默
CN106381296A (zh) * 2015-11-19 2017-02-08 中国农业科学院哈尔滨兽医研究所 表达多基因抗流感转基因动物的构建方法
CN106947763B (zh) * 2017-03-20 2019-11-12 中国医学科学院医药生物技术研究所 可雾化吸入的抗流感病毒感染的siRNA及其应用
AU2020215613A1 (en) 2019-02-01 2021-08-19 The Board Of Trustees Of The Leland Stanford Junior University Immolative cell-penetrating complexes for nucleic acid delivery to the lung
CN114206906B (zh) * 2019-07-10 2024-02-20 香港大学 Peg化的合成kl4肽、其组合物和方法

Also Published As

Publication number Publication date
CN101180395A (zh) 2008-05-14
IL186057A0 (en) 2008-01-20
MX2007011665A (es) 2007-11-14
JP2008533990A (ja) 2008-08-28

Similar Documents

Publication Publication Date Title
NO20074929L (no) Influensa terapeutisk middel
WO2006102461A3 (en) Influenza therapeutic
Cai et al. Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b
US10167474B2 (en) Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
Yu et al. Inhibiting microRNA-144 abates oxidative stress and reduces apoptosis in hearts of streptozotocin-induced diabetic mice
Liang et al. IncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR‐30c
Wei et al. NF-κB-mediated miR-30b regulation in cardiomyocytes cell death by targeting Bcl-2
Baldassarre et al. Potential use of noncoding RNAs and innovative therapeutic strategies to target the 5’UTR of SARS-CoV-2
JP2019508045A (ja) がんを処置するための組み合わせベクターおよび方法
Huang et al. Eriocheir sinensis microRNA-7 targets crab Myd88 to enhance white spot syndrome virus replication
AU2019203090B2 (en) E.COLI MEDIATED siRNASILENCING OF AVIAN INFLUENZA IN CHICKENS
Xie et al. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
Samir et al. Small non-coding RNAs associated with viral infectious diseases of veterinary importance: potential clinical applications
Lee et al. ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions
Huang et al. MicroRNA-133b negatively regulates zebrafish single Mauthner-cell axon regeneration through targeting TPPP3 in vivo
Gotesman et al. In vitro inhibition of Cyprinid herpesvirus-3 replication by RNAi
US20120039905A1 (en) The Role of p110 delta Signaling in Morbidity and Lung Pathology Induced by Influenza Virus Infection
Stoppani et al. Expression of a single siRNA against a conserved region of NP gene strongly inhibits in vitro replication of different Influenza A virus strains of avian and swine origin
Gao et al. Molecular breeding of livestock for disease resistance
Zhang et al. Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge
Liu et al. Mycoplasma hyopneumoniae infection activates the NOD1 signaling pathway to modulate inflammation
JP4054844B2 (ja) 副作用のないＲＮＡｉ医薬
Yang et al. Porcine ZC3H11A is essential for the proliferation of pseudorabies virus and porcine circovirus 2
Alexopoulou Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome
Ghosh Therapeutic modulation of miRNA-320a to prevent diabetic cardiomyopathy

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application