NO20074929L - Influenza therapeutic agent - Google Patents
Influenza therapeutic agentInfo
- Publication number
- NO20074929L NO20074929L NO20074929A NO20074929A NO20074929L NO 20074929 L NO20074929 L NO 20074929L NO 20074929 A NO20074929 A NO 20074929A NO 20074929 A NO20074929 A NO 20074929A NO 20074929 L NO20074929 L NO 20074929L
- Authority
- NO
- Norway
- Prior art keywords
- rnai
- influenza
- inducing
- influenza virus
- provides
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SAMMENDRAG Foreliggende oppfinnelse tilveiebringe r blandinger omfattende en RNAi-induserende enhet målrettet mot et influensavirus-transkript og hvilke som helst av en rekke midler for levering. Oppfinnelsen omfatter videre fremgangsmåter for anvendelse av blandingene for å hemme en biologisk aktivitet av et influensavirus og/eller for behandling eller forebygging av influensa. Oppfinnelsen tilveiebringer mål-andel sekvenser som er fordelaktig konservert for RNAi gjennom en rekke influensavirus A-stammer isolert fra humane verter og/eller fugle-verter og RNAi-induserende enheter, f.eks. siRNA'er og shRNA'er, målrettet mot slike fordelaktig konserverte mål-andeler. Oppfinnelsen tilveiebringer en rekke nukleinsyrer omfattende sekvenser identiske eller komplementære til minst en del av én eller flere av disse fordelaktig konserverte mål-andel-sekvensene. Oppfinnelsen tilveiebringer videre fremgangsmåter og blandinger for levering av RNAi-induserende midler til et organ eller vev av et mammalsk subjekt, f.eks. til lungen. Fremgangsmåter for diagnostisering av influensa og bestemmelse av følsomheten av et influensavirus for hemming ved et RNAi-induserende middel tilveiebringes også. Transgene dyr som uttrykker et RNAi-induserende middel målrettet mot et influensa-gen er et annet aspekt ved oppfinnelsen.SUMMARY OF THE INVENTION The present invention provides compositions comprising an RNAi-inducing unit targeting a influenza virus transcript and any of a variety of means for delivery. The invention further encompasses methods for using the compositions to inhibit the biological activity of an influenza virus and / or for the treatment or prevention of influenza. The invention provides target proportion sequences that are advantageously conserved for RNAi through a variety of influenza virus A strains isolated from human and / or bird hosts and RNAi-inducing units, e.g. siRNAs and shRNAs, targeting such advantageously conserved target moieties. The invention provides a number of nucleic acids comprising sequences identical or complementary to at least part of one or more of these advantageously conserved target-share sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g. to the lung. Methods for diagnosing influenza and determining the sensitivity of an influenza virus to inhibition by an RNAi inducing agent are also provided. Transgenic animals expressing an RNAi-inducing agent targeted to the influenza gene are another aspect of the invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66458005P | 2005-03-22 | 2005-03-22 | |
| US11/102,097 US20060160759A1 (en) | 2002-09-28 | 2005-04-08 | Influenza therapeutic |
| PCT/US2006/010491 WO2006102461A2 (en) | 2005-03-22 | 2006-03-22 | Influenza therapeutic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20074929L true NO20074929L (en) | 2007-12-18 |
Family
ID=39406020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20074929A NO20074929L (en) | 2005-03-22 | 2007-09-28 | Influenza therapeutic agent |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2008533990A (en) |
| CN (1) | CN101180395A (en) |
| IL (1) | IL186057A0 (en) |
| MX (1) | MX2007011665A (en) |
| NO (1) | NO20074929L (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103966212A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus NP gene and application |
| CN103966213A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus M gene and identification on interference effect |
| CN103966214A (en) * | 2013-02-06 | 2014-08-06 | 霍晋 | Design of siRNA sequences possessing interference effect on influenza A virus NP gene and application |
| DK3011031T3 (en) * | 2013-06-17 | 2020-12-21 | Broad Inst Inc | PERFORMANCE AND APPLICATION OF CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR LIVER TARGET DIRECTION AND THERAPY |
| CN112410275A (en) * | 2014-01-23 | 2021-02-26 | 科罗拉多州立大学研究基金会 | E.coli mediated siRNA silencing of influenza |
| CN106381296A (en) * | 2015-11-19 | 2017-02-08 | 中国农业科学院哈尔滨兽医研究所 | Construction method for anti-influenza transgenic animal capable of expressing multiple genes |
| CN106947763B (en) * | 2017-03-20 | 2019-11-12 | 中国医学科学院医药生物技术研究所 | The siRNA of the resisiting influenza virus infection of aerosolizable sucking and its application |
| EP3917574A4 (en) * | 2019-02-01 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | Immolative cell-penetrating complexes for nucleic acid delivery to the lung |
| CN114206906B (en) * | 2019-07-10 | 2024-02-20 | 香港大学 | PEGylated synthetic KL4 peptides, compositions and methods thereof |
-
2006
- 2006-03-22 MX MX2007011665A patent/MX2007011665A/en not_active Application Discontinuation
- 2006-03-22 JP JP2008503156A patent/JP2008533990A/en active Pending
- 2006-03-22 CN CNA2006800177344A patent/CN101180395A/en active Pending
-
2007
- 2007-09-19 IL IL186057A patent/IL186057A0/en unknown
- 2007-09-28 NO NO20074929A patent/NO20074929L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008533990A (en) | 2008-08-28 |
| CN101180395A (en) | 2008-05-14 |
| MX2007011665A (en) | 2007-11-14 |
| IL186057A0 (en) | 2008-01-20 |
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