NO20074912L - 2-sulfinyl- og 2-sulfonyl-substituerte imidazolderivater og anvendelse derav som cytokininhibitorer - Google Patents

2-sulfinyl- og 2-sulfonyl-substituerte imidazolderivater og anvendelse derav som cytokininhibitorer

Info

Publication number
NO20074912L
NO20074912L NO20074912A NO20074912A NO20074912L NO 20074912 L NO20074912 L NO 20074912L NO 20074912 A NO20074912 A NO 20074912A NO 20074912 A NO20074912 A NO 20074912A NO 20074912 L NO20074912 L NO 20074912L
Authority
NO
Norway
Prior art keywords
sulfinyl
sulfonyl
imidazole derivatives
substituted imidazole
cytokine inhibitors
Prior art date
Application number
NO20074912A
Other languages
English (en)
Inventor
Karola Tollmann
Philipp Merckle
Wolfgang Albrecht
Cornelia Greim
Hans-Guenter Striegel
Stefan Laufer
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of NO20074912L publication Critical patent/NO20074912L/no

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

Oppfinnelsen angår 2-sulfinyl- eller 2-sulfonylsubstituerte imidazolderivater med formel (I) hvor radikalene R1, R2 , R3 og R4 har betydningene angitt i beskrivelsen. Disse forbindelsene har en immunmodulerende og/eller cytokinfrigjøringsinhiberende virkning og er derfor egnet for behandling av lidelser forbundet med svekket immunsystem.
NO20074912A 2005-02-28 2007-09-27 2-sulfinyl- og 2-sulfonyl-substituerte imidazolderivater og anvendelse derav som cytokininhibitorer NO20074912L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65638905P 2005-02-28 2005-02-28
EP05004369 2005-02-28
PCT/EP2006/001801 WO2006089798A1 (en) 2005-02-28 2006-02-27 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors

Publications (1)

Publication Number Publication Date
NO20074912L true NO20074912L (no) 2007-11-28

Family

ID=34933989

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074912A NO20074912L (no) 2005-02-28 2007-09-27 2-sulfinyl- og 2-sulfonyl-substituerte imidazolderivater og anvendelse derav som cytokininhibitorer

Country Status (20)

Country Link
US (1) US20100273833A1 (no)
EP (1) EP1853581B1 (no)
JP (1) JP2008531627A (no)
KR (1) KR20070107082A (no)
CN (1) CN101128453A (no)
AT (1) ATE469893T1 (no)
AU (1) AU2006218037B2 (no)
BR (1) BRPI0608739A2 (no)
CA (1) CA2599449A1 (no)
DE (1) DE602006014657D1 (no)
DK (1) DK1853581T3 (no)
ES (1) ES2351308T3 (no)
IL (1) IL184745A0 (no)
MX (1) MX2007010496A (no)
NO (1) NO20074912L (no)
NZ (1) NZ560264A (no)
PT (1) PT1853581E (no)
RU (1) RU2007135955A (no)
WO (1) WO2006089798A1 (no)
ZA (1) ZA200708203B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1894925A1 (en) * 2006-08-24 2008-03-05 Merckle Gmbh Imidazole compounds having an antiinflammatory effect
US8143294B2 (en) 2007-12-31 2012-03-27 Michael Burnet 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors
CN102249992A (zh) * 2011-07-05 2011-11-23 广东工业大学 一种制备2-氨基异烟酸的方法
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US11479770B2 (en) 2017-10-05 2022-10-25 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of DUX4

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010014288A (ko) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 염증성 질환의 치료에 유용한 2-치환된 이미다졸
GB9713726D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
ATE323482T1 (de) * 1999-07-02 2006-05-15 Stuart A Lipton Verwendung von p38 mapk inhibitoren in der behandlung von augenkrankheiten
DE10107683A1 (de) * 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10114775A1 (de) * 2001-03-26 2002-10-10 Gerhard Dannhardt 2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie
KR20020009532A (ko) * 2001-11-13 2002-02-01 (주)쎌믹스 류코트리엔 합성 억제용 조성물
DE10222103A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) * 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Also Published As

Publication number Publication date
DK1853581T3 (da) 2010-09-27
EP1853581B1 (en) 2010-06-02
NZ560264A (en) 2009-11-27
KR20070107082A (ko) 2007-11-06
AU2006218037B2 (en) 2012-04-05
ES2351308T3 (es) 2011-02-02
ATE469893T1 (de) 2010-06-15
CA2599449A1 (en) 2006-08-31
AU2006218037A1 (en) 2006-08-31
ZA200708203B (en) 2008-10-29
RU2007135955A (ru) 2009-04-10
PT1853581E (pt) 2010-09-09
CN101128453A (zh) 2008-02-20
WO2006089798A1 (en) 2006-08-31
MX2007010496A (es) 2007-11-07
EP1853581A1 (en) 2007-11-14
IL184745A0 (en) 2007-12-03
BRPI0608739A2 (pt) 2011-03-15
US20100273833A1 (en) 2010-10-28
DE602006014657D1 (de) 2010-07-15
JP2008531627A (ja) 2008-08-14

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