NO20074770L - Polyoksyalkylenderivat - Google Patents
PolyoksyalkylenderivatInfo
- Publication number
- NO20074770L NO20074770L NO20074770A NO20074770A NO20074770L NO 20074770 L NO20074770 L NO 20074770L NO 20074770 A NO20074770 A NO 20074770A NO 20074770 A NO20074770 A NO 20074770A NO 20074770 L NO20074770 L NO 20074770L
- Authority
- NO
- Norway
- Prior art keywords
- polyoxyalkylene
- reacting
- symbol
- disclosure
- following formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005041523 | 2005-02-18 | ||
| PCT/JP2006/303359 WO2006088248A1 (fr) | 2005-02-18 | 2006-02-17 | Derive de polyoxyalkylene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20074770L true NO20074770L (no) | 2007-11-15 |
Family
ID=36916633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20074770A NO20074770L (no) | 2005-02-18 | 2007-09-18 | Polyoksyalkylenderivat |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8012488B2 (fr) |
| EP (1) | EP1857462B9 (fr) |
| JP (1) | JP4877225B2 (fr) |
| NO (1) | NO20074770L (fr) |
| WO (1) | WO2006088248A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090285780A1 (en) * | 2006-05-24 | 2009-11-19 | Chyi Lee | Peg linker compounds and biologically active conjugates thereof |
| EP2073820A4 (fr) * | 2006-09-15 | 2014-07-16 | Belrose Pharma Inc | Promédicaments polymères ciblés contenant des segments de liaison multifonctionnels |
| US9828597B2 (en) | 2006-11-22 | 2017-11-28 | Toyota Motor Engineering & Manufacturing North America, Inc. | Biofunctional materials |
| WO2008112289A2 (fr) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Conjugués d'oligomère-inhibiteur de protéase |
| US11015149B2 (en) | 2010-06-21 | 2021-05-25 | Toyota Motor Corporation | Methods of facilitating removal of a fingerprint |
| US9388370B2 (en) | 2010-06-21 | 2016-07-12 | Toyota Motor Engineering & Manufacturing North America, Inc. | Thermolysin-like protease for cleaning insect body stains |
| US10988714B2 (en) | 2010-06-21 | 2021-04-27 | Regents Of The University Of Minnesota | Methods of facilitating removal of a fingerprint from a substrate or a coating |
| US8796009B2 (en) | 2010-06-21 | 2014-08-05 | Toyota Motor Engineering & Manufacturing North America, Inc. | Clearcoat containing thermolysin-like protease from Bacillus stearothermophilus for cleaning of insect body stains |
| US9121016B2 (en) * | 2011-09-09 | 2015-09-01 | Toyota Motor Engineering & Manufacturing North America, Inc. | Coatings containing polymer modified enzyme for stable self-cleaning of organic stains |
| US10040761B2 (en) * | 2010-06-25 | 2018-08-07 | Nof Corporation | Branched hetero polyethylene glycol and intermediate |
| JP5825507B2 (ja) * | 2010-06-25 | 2015-12-02 | 日油株式会社 | 分岐型ヘテロポリエチレングリコール |
| WO2015057699A2 (fr) | 2013-10-15 | 2015-04-23 | Seattle Genetics, Inc. | Lieurs de médicaments pégylés pour pharmacocinétique de conjugués ligand-médicament améliorée |
| CA3006000A1 (fr) | 2015-12-04 | 2017-06-08 | Seattle Genetics, Inc. | Conjugues de composes de tubulysine quaternises |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| MA43835A (fr) | 2016-03-25 | 2018-11-28 | Seattle Genetics Inc | Procédé de préparation de lieurs de médicaments pégylés et leurs intermédiaires |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| AU2018237683A1 (en) | 2017-03-24 | 2019-10-31 | Seagen Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
| MX2020004332A (es) * | 2017-11-06 | 2020-08-03 | Hanmi Fine Chemical Co Ltd | Derivado de polietilenglicol y metodo de preparacion del mismo. |
| EP3778705A4 (fr) * | 2018-03-29 | 2022-01-05 | NOF Corporation | Dérivé de polyéthylène glycol dégradable |
| US20210023231A1 (en) | 2018-03-29 | 2021-01-28 | Nof Corporation | Degradable polyethylene glycol conjugate |
| CA3135346A1 (fr) | 2019-03-29 | 2020-10-08 | Nof Corporation | Derive de polyethylene glycol ramifie et degradable |
| KR20210144858A (ko) | 2019-03-29 | 2021-11-30 | 니치유 가부시키가이샤 | 분기형 분해성 폴리에틸렌 글리콜 결합체 |
| WO2020213015A1 (fr) * | 2019-04-15 | 2020-10-22 | Nof Corporation | Conjugué de substance biologique et de polymère séquencé et dérivé de polymère séquencé pour obtenir ledit conjugué |
| EP4035678A4 (fr) * | 2019-09-26 | 2023-10-18 | NOF Corporation | Dérivé dégradable de polyéthylène glycol à branches multiples |
| EP4036150A4 (fr) * | 2019-09-26 | 2023-12-27 | NOF Corporation | Dérivé de polyéthylène glycol ramifié asymétriquement, dégradable |
| US20220362397A1 (en) * | 2019-09-26 | 2022-11-17 | Nof Corporation | Heterobifunctional monodispersed polyethylene glycol having peptide linker |
| CA3164940A1 (fr) * | 2019-12-27 | 2021-07-01 | Nof Corporation | Procede de purification de polyethylene glycol ramifie |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0437563T3 (da) | 1989-08-07 | 1995-05-29 | Debio Rech Pharma Sa | Bioligiske aktive lægemiddelpolymerderivater |
| JPH0421636A (ja) | 1990-05-17 | 1992-01-24 | Ajinomoto Co Inc | 肝機能改善剤 |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| DK1007082T3 (da) | 1997-01-15 | 2007-02-19 | Phoenix Pharmacologics Inc | Modificeret tumor nekrose faktor |
| IL122933A (en) | 1998-01-14 | 2005-03-20 | Efrat Biopolymers Ltd | Polymeric carrier for delivery of a bioactive molecule |
| DE69925830T2 (de) * | 1998-04-28 | 2006-05-04 | Applied Research Systems Ars Holding N.V. | Peg-lhrh analog konjugate |
| WO2001046220A2 (fr) * | 1999-12-22 | 2001-06-28 | Polymun Scientific Immunbiologische Forschung Gmbh | Oligopeptides bioactifs |
| JP4152187B2 (ja) | 2001-01-30 | 2008-09-17 | 協和醗酵工業株式会社 | 分岐型ポリアルキレングリコール類 |
| JP4123856B2 (ja) * | 2001-07-31 | 2008-07-23 | 日油株式会社 | 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法 |
| JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
| KR101025143B1 (ko) * | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드－종결 중합체 |
| JP2006025766A (ja) | 2004-07-21 | 2006-02-02 | Nof Corp | 細胞表面オプソニン化剤 |
-
2006
- 2006-02-17 JP JP2007503804A patent/JP4877225B2/ja active Active
- 2006-02-17 WO PCT/JP2006/303359 patent/WO2006088248A1/fr active Application Filing
- 2006-02-17 US US11/816,611 patent/US8012488B2/en active Active
- 2006-02-17 EP EP06714498A patent/EP1857462B9/fr active Active
-
2007
- 2007-09-18 NO NO20074770A patent/NO20074770L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006088248A1 (fr) | 2006-08-24 |
| JP4877225B2 (ja) | 2012-02-15 |
| US8012488B2 (en) | 2011-09-06 |
| JPWO2006088248A1 (ja) | 2008-07-17 |
| EP1857462B9 (fr) | 2013-02-13 |
| EP1857462A1 (fr) | 2007-11-21 |
| EP1857462B1 (fr) | 2011-12-07 |
| EP1857462A4 (fr) | 2009-06-24 |
| US20090023859A1 (en) | 2009-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |