NO20073823L - Kinolinderivater for behandlingen av latent tuberkulose - Google Patents
Kinolinderivater for behandlingen av latent tuberkuloseInfo
- Publication number
- NO20073823L NO20073823L NO20073823A NO20073823A NO20073823L NO 20073823 L NO20073823 L NO 20073823L NO 20073823 A NO20073823 A NO 20073823A NO 20073823 A NO20073823 A NO 20073823A NO 20073823 L NO20073823 L NO 20073823L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anvendelse av en forbindelse med formel (Ia) eller (Ib) for fremstillingen av et medikament for behandlingen av latent tuberkulose, hvori forbindelsen med formel (Ia) eller (Ib) er (Ia) (Ib) et farmasøytisk akseptabelt salt, et kvaternært amin, et N-oksid, en tautomer form eller en stereokjemisk isomer form derav hvori R1 er hydrogen, halo, haloalkyl, cyano, hydroksy, Ar, Het, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; p er 1, 2, 3 eller 4; R2 er hydrogen, hydroksy, merkapto, alkyloksy, alkyloksyalkyloksy, alkyltio, mono eller di(alkyl)amino eller et radikal med formel ; R3 er alkyl, Ar, Ar-alkyl, Het eller Het-alkyl; q er null, 1, 2, 3 eller 4; R4 og R5 er hver uavhengig hydrogen, alkyl eller benzyl; eller R4 og R5 kan tas sammen inklusive N til hvilket de er bundet; R6 er hydrogen, halo, haloalkyl, hydroksy, Ar, alkyl, alkyloksy, alkyltio, alkyloksyalkyl, alkyltioalkyl, Ar-alkyl eller di(Ar)alkyl; eller to vicinale R6-radikaler kan tas sammen for å danne et bivalent radikal -CH=CH-CH=CH-; r er 1, 2, 3, 4 eller 5; R7 er hydrogen, alkyl, Ar eller Het; R8 er hydrogen eller alkyl; R9 er okso; eller R8 og R9 danner sammen radikalet =N-CH=CH- . ?? ?? ?? ?? 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04078529 | 2004-12-24 | ||
| EP05105008 | 2005-06-08 | ||
| PCT/EP2005/056594 WO2006067048A1 (en) | 2004-12-24 | 2005-12-08 | Quinoline derivatives for the treatment of latent tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20073823L true NO20073823L (no) | 2007-07-23 |
| NO340376B1 NO340376B1 (no) | 2017-04-10 |
Family
ID=35717702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073823A NO340376B1 (no) | 2004-12-24 | 2007-07-23 | Kinolinderivater for behandlingen av latent tuberkulose |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060142279A1 (no) |
| EP (1) | EP1830850B1 (no) |
| CN (1) | CN103142595B (no) |
| AP (1) | AP2327A (no) |
| AR (1) | AR051790A1 (no) |
| AT (1) | ATE501721T1 (no) |
| AU (1) | AU2005242138B2 (no) |
| BR (1) | BRPI0506400B8 (no) |
| CA (1) | CA2529265C (no) |
| CR (1) | CR9267A (no) |
| CY (1) | CY1112247T1 (no) |
| DE (1) | DE602005026984D1 (no) |
| DK (1) | DK1830850T3 (no) |
| EE (1) | EE05394B1 (no) |
| HK (1) | HK1186125A1 (no) |
| HR (1) | HRP20110392T1 (no) |
| IL (1) | IL184123A (no) |
| LV (1) | LV13469B (no) |
| ME (1) | ME01207B (no) |
| MY (1) | MY145845A (no) |
| NI (1) | NI200700146A (no) |
| NO (1) | NO340376B1 (no) |
| NZ (1) | NZ555460A (no) |
| PA (1) | PA8654801A1 (no) |
| PL (1) | PL1830850T3 (no) |
| PT (1) | PT1830850E (no) |
| RS (1) | RS51730B (no) |
| SI (1) | SI1830850T1 (no) |
| TR (1) | TR200504892A1 (no) |
| TW (1) | TWI404535B (no) |
| WO (1) | WO2006067048A1 (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO342701B1 (no) * | 2005-06-28 | 2018-07-09 | Janssen Pharmaceutica Nv | Kinolinderivater som antibakterielle midler |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
| JO3270B1 (ar) * | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| CA2612614C (en) * | 2005-06-28 | 2017-07-25 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) * | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| US20110059948A1 (en) * | 2008-01-14 | 2011-03-10 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as anti-mycobacterial agents |
| RU2404971C2 (ru) * | 2008-12-02 | 2010-11-27 | ЗАО "Фарм-Синтез" | Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе |
| WO2010083436A1 (en) | 2009-01-15 | 2010-07-22 | Rutgers, The State University Of New Jersey | Benzo [c] phenanthridines as antimicrobial agents |
| CA2760526A1 (en) | 2009-04-30 | 2010-11-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| CA2810162A1 (en) | 2010-06-09 | 2011-12-15 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| WO2011163610A2 (en) * | 2010-06-25 | 2011-12-29 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| WO2013106756A2 (en) | 2012-01-13 | 2013-07-18 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| AU2013235038A1 (en) | 2012-03-21 | 2014-10-09 | Malvika Kaul | Antimicrobial agents |
| WO2013160431A1 (en) | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| ES2576491T3 (es) | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
| SG11201705944TA (en) | 2015-01-27 | 2017-08-30 | Janssen Pharmaceutica Nv | Dispersible compositions |
| WO2017147316A1 (en) | 2016-02-25 | 2017-08-31 | Taxis Pharmaceuticals, Inc. | Synthetic processes and intermediates |
| CA3016068C (en) | 2016-03-07 | 2024-02-27 | The Global Alliance For Tb Drug Development, Inc. | Antibacterial compounds and uses thereof |
| RU2629369C1 (ru) * | 2016-10-05 | 2017-08-29 | Федеральное Государственное Унитарное Предприятие "Государственный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Химических Реактивов И Особо Чистых Химических Веществ" | Четвертичные аммонийные производные 2-аминотиофен-3-карбоксилатов, обладающие противотуберкулезной активностью |
| US10774093B2 (en) | 2017-03-30 | 2020-09-15 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
| EP3651736B1 (en) | 2017-07-14 | 2021-06-23 | Janssen Pharmaceutica NV | Long-acting formulations |
| RU2661151C1 (ru) * | 2017-12-14 | 2018-07-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Селективные ингибиторы глицеральдегид-3-фосфатдегидрогеназы микобактерий |
| JP2022516671A (ja) | 2019-01-09 | 2022-03-01 | ヤンセン ファーマシューティカ エヌ．ベー． | 非結核性抗酸菌症の処置における組合せ |
| EP4178541A1 (en) | 2020-07-09 | 2023-05-17 | JANSSEN Pharmaceutica NV | Long-acting formulations |
| AU2021303490A1 (en) | 2020-07-09 | 2023-03-09 | Janssen Pharmaceutica Nv | Long-acting formulations |
| US20230346770A1 (en) | 2020-11-12 | 2023-11-02 | Janssen Pharmaceutica Nv | Combination of bedaquiline, ethambutol and a macrolide in the treatment of nontuberculous mycobacterial diseases |
| WO2023232838A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Pharmaceutica Nv | Bedaquiline for use in the treatment of leprosy |
| WO2024068699A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
| WO2024068693A1 (en) | 2022-09-28 | 2024-04-04 | Janssen Pharmaceutica Nv | Long-acting formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| DK2301544T3 (da) * | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
-
2005
- 2005-12-05 EE EEP200500033A patent/EE05394B1/xx unknown
- 2005-12-06 CA CA2529265A patent/CA2529265C/en active Active
- 2005-12-07 AU AU2005242138A patent/AU2005242138B2/en active Active
- 2005-12-07 PA PA20058654801A patent/PA8654801A1/es unknown
- 2005-12-07 MY MYPI20055732A patent/MY145845A/en unknown
- 2005-12-08 SI SI200531294T patent/SI1830850T1/sl unknown
- 2005-12-08 TR TR2005/04892A patent/TR200504892A1/xx unknown
- 2005-12-08 RS RS20110221A patent/RS51730B/en unknown
- 2005-12-08 TW TW094143290A patent/TWI404535B/zh active
- 2005-12-08 EP EP05815816A patent/EP1830850B1/en active Active
- 2005-12-08 CN CN201210507318.XA patent/CN103142595B/zh active Active
- 2005-12-08 AP AP2007004054A patent/AP2327A/xx active
- 2005-12-08 PL PL05815816T patent/PL1830850T3/pl unknown
- 2005-12-08 NZ NZ555460A patent/NZ555460A/en unknown
- 2005-12-08 PT PT05815816T patent/PT1830850E/pt unknown
- 2005-12-08 US US11/296,992 patent/US20060142279A1/en not_active Abandoned
- 2005-12-08 WO PCT/EP2005/056594 patent/WO2006067048A1/en active Application Filing
- 2005-12-08 DE DE602005026984T patent/DE602005026984D1/de active Active
- 2005-12-08 AT AT05815816T patent/ATE501721T1/de active
- 2005-12-08 ME MEP-2011-92A patent/ME01207B/me unknown
- 2005-12-08 BR BRPI0506400A patent/BRPI0506400B8/pt active IP Right Grant
- 2005-12-08 DK DK05815816.3T patent/DK1830850T3/da active
- 2005-12-09 AR ARP050105140A patent/AR051790A1/es unknown
- 2005-12-09 LV LVP-05-161A patent/LV13469B/lv unknown
-
2007
- 2007-06-05 NI NI200700146A patent/NI200700146A/es unknown
- 2007-06-21 IL IL184123A patent/IL184123A/en active IP Right Grant
- 2007-07-20 CR CR9267A patent/CR9267A/es not_active Application Discontinuation
- 2007-07-23 NO NO20073823A patent/NO340376B1/no unknown
-
2011
- 2011-05-24 HR HR20110392T patent/HRP20110392T1/hr unknown
- 2011-06-15 CY CY20111100563T patent/CY1112247T1/el unknown
-
2013
- 2013-12-09 HK HK13113666.1A patent/HK1186125A1/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO342701B1 (no) * | 2005-06-28 | 2018-07-09 | Janssen Pharmaceutica Nv | Kinolinderivater som antibakterielle midler |
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