NO20062904L - Anvendelse av 4-hydroksy tamoxifen for fremstilling av et medikament for behandling av gynekomasti - Google Patents

Anvendelse av 4-hydroksy tamoxifen for fremstilling av et medikament for behandling av gynekomasti

Info

Publication number
NO20062904L
NO20062904L NO20062904A NO20062904A NO20062904L NO 20062904 L NO20062904 L NO 20062904L NO 20062904 A NO20062904 A NO 20062904A NO 20062904 A NO20062904 A NO 20062904A NO 20062904 L NO20062904 L NO 20062904L
Authority
NO
Norway
Prior art keywords
gynecomastia
hydroxy tamoxifen
drug
preparation
treatment
Prior art date
Application number
NO20062904A
Other languages
English (en)
Other versions
NO336463B1 (no
Inventor
Elisabeth Le Nestour
Andrew R Palumbo
Original Assignee
Ascend Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/734,640 external-priority patent/US7786172B2/en
Priority claimed from EP03293156A external-priority patent/EP1550440A1/en
Application filed by Ascend Therapeutics Inc filed Critical Ascend Therapeutics Inc
Publication of NO20062904L publication Critical patent/NO20062904L/no
Publication of NO336463B1 publication Critical patent/NO336463B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oppfinnelsen skaffer til veie fremgangsmåter for behandling og forebygging av gynekomasti ved administrering av 4-hydroksy tamoxifen til en pasient. Når det administreres perkutant til en pasients bryst, konsentteres 4-hydroksy tamoxifen lokalt, og utøver en anti-østtogen effekt. Hos pasienter med gynekomasti, reduserer dette det effektive østtogen-androgen forholdet i brystvevet, for dermed å redusere duktal proliferasjon, epitel og sttomal hyperplasi og smerte. Hos pasienter med risiko for utvikling av gynekomasti, forhindrer 4-hydroksy tamoxifens anti-østrogene effekt, vevsproliferasjon og dens ledsagende smerte.
NO20062904A 2003-12-15 2006-06-21 Anvendelse av 4-hydroksytamoxifen for fremstilling av et medikament for behandling av gynekomasti NO336463B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/734,640 US7786172B2 (en) 2002-12-18 2003-12-15 Treatment of mastalgia with 4-hydroxy tamoxifen
EP03293156A EP1550440A1 (en) 2003-12-15 2003-12-15 Use of 4-hydroxytamoxifen for the preparation of a medicament for the treatment of gynecomastia
PCT/EP2004/014295 WO2005058297A1 (en) 2003-12-15 2004-12-13 Use of 4-hydroxytamoxifen for the preparation of a medicament for the treatment of gynecomastia

Publications (2)

Publication Number Publication Date
NO20062904L true NO20062904L (no) 2006-06-21
NO336463B1 NO336463B1 (no) 2015-08-31

Family

ID=34702366

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062904A NO336463B1 (no) 2003-12-15 2006-06-21 Anvendelse av 4-hydroksytamoxifen for fremstilling av et medikament for behandling av gynekomasti

Country Status (15)

Country Link
EP (1) EP1694319B1 (no)
JP (1) JP5069469B2 (no)
AT (1) ATE401067T1 (no)
AU (1) AU2004298349B2 (no)
CA (1) CA2549824C (no)
DE (1) DE602004015146D1 (no)
DK (1) DK1694319T3 (no)
ES (1) ES2310765T3 (no)
HK (1) HK1094768A1 (no)
MX (1) MXPA06006834A (no)
NO (1) NO336463B1 (no)
NZ (1) NZ547744A (no)
PL (1) PL1694319T3 (no)
PT (1) PT1694319E (no)
WO (1) WO2005058297A1 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO337298B1 (no) * 2004-03-22 2016-03-07 Besins Healthcare Lu Sarl Kjemisk stabile preparater av 4-hydroksytamoksifen

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1748770E (pt) * 2004-03-22 2008-07-16 Besins Int Lab Tratamento e prevenção de doença benigna da mama com 4-hidroxi-tamoxifeno
ATE415156T1 (de) * 2004-10-14 2008-12-15 Besins Int Lab 4-hydroxytamoxifengel-formulierungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
IL120268A0 (en) * 1996-02-28 1997-06-10 Pfizer Use of (E)-1-[4'-(2-alkylaminoethioxy)phenyl]1-(3'-hydroxyphenyl)-2-phenylbut-1-enes in inhibiting pathological conditions
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
PT1210951E (pt) * 2000-11-30 2005-04-29 Pfizer Prod Inc Composicao que contem agonistas/antagonistas de estrogeneo e testosterona para tartamento de um declinio do nivel da hormona testosterona
CN1599606A (zh) * 2001-07-31 2005-03-23 辉瑞产品公司 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法
ES2330188T3 (es) * 2001-12-07 2009-12-07 Besins Manufacturing Belgium Composicion farmaceutica en forma de gel o de solucion a base de dihidrotestoterona, su procedimiento de preparacion y sus utilizaciones.
CA2528431C (en) * 2003-06-09 2012-09-18 Northwestern University Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO337298B1 (no) * 2004-03-22 2016-03-07 Besins Healthcare Lu Sarl Kjemisk stabile preparater av 4-hydroksytamoksifen

Also Published As

Publication number Publication date
JP2007529420A (ja) 2007-10-25
EP1694319A1 (en) 2006-08-30
NO336463B1 (no) 2015-08-31
JP5069469B2 (ja) 2012-11-07
DK1694319T3 (da) 2008-11-17
CA2549824C (en) 2012-03-13
ATE401067T1 (de) 2008-08-15
AU2004298349A1 (en) 2005-06-30
HK1094768A1 (en) 2007-04-13
PL1694319T3 (pl) 2009-01-30
WO2005058297A1 (en) 2005-06-30
ES2310765T3 (es) 2009-01-16
DE602004015146D1 (de) 2008-08-28
CA2549824A1 (en) 2005-06-30
NZ547744A (en) 2009-09-25
MXPA06006834A (es) 2006-09-04
AU2004298349B2 (en) 2010-02-25
EP1694319B1 (en) 2008-07-16
PT1694319E (pt) 2008-10-24

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: ASCEND THERAPEUTICS INC, LU

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BESINS HEALTHCARE LUXEMBOURG SARL, LU

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BESINS HEALTHCARE LUXEMBOURG SARL, LU