NO20062633L - Pyrazolderivater som proteinkinasemodulatorer - Google Patents
Pyrazolderivater som proteinkinasemodulatorerInfo
- Publication number
- NO20062633L NO20062633L NO20062633A NO20062633A NO20062633L NO 20062633 L NO20062633 L NO 20062633L NO 20062633 A NO20062633 A NO 20062633A NO 20062633 A NO20062633 A NO 20062633A NO 20062633 L NO20062633 L NO 20062633L
- Authority
- NO
- Norway
- Prior art keywords
- group
- atoms
- protein kinase
- carbon atoms
- compounds
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005647 linker group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 108091008611 Protein Kinase B Proteins 0.000 abstract 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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Applications Claiming Priority (4)
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US53219903P | 2003-12-23 | 2003-12-23 | |
GB0329617A GB0329617D0 (en) | 2003-12-23 | 2003-12-23 | Pharmaceutical compounds |
US57784304P | 2004-06-08 | 2004-06-08 | |
PCT/GB2004/005464 WO2005061463A1 (en) | 2003-12-23 | 2004-12-23 | Pyrazole derivatives as protein kinase modulators |
Publications (1)
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NO20062633L true NO20062633L (no) | 2006-07-20 |
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NO20062633A NO20062633L (no) | 2003-12-23 | 2006-06-08 | Pyrazolderivater som proteinkinasemodulatorer |
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US (4) | US8247576B2 (ja) |
EP (2) | EP2228369A1 (ja) |
JP (1) | JP4928949B2 (ja) |
KR (1) | KR101164258B1 (ja) |
AU (1) | AU2004303602C1 (ja) |
BR (1) | BRPI0418078A8 (ja) |
CA (1) | CA2548374C (ja) |
CY (1) | CY1111493T1 (ja) |
HK (1) | HK1097543A1 (ja) |
HR (1) | HRP20100675T1 (ja) |
IL (1) | IL176400A (ja) |
MX (1) | MXPA06007326A (ja) |
NO (1) | NO20062633L (ja) |
NZ (1) | NZ547696A (ja) |
PL (1) | PL1706385T3 (ja) |
UY (1) | UY28946A1 (ja) |
WO (1) | WO2005061463A1 (ja) |
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2004
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- 2004-12-23 PL PL04806258T patent/PL1706385T3/pl unknown
- 2004-12-23 BR BRPI0418078A patent/BRPI0418078A8/pt active Search and Examination
- 2004-12-23 JP JP2006546339A patent/JP4928949B2/ja not_active Expired - Fee Related
- 2004-12-23 EP EP10168024A patent/EP2228369A1/en not_active Withdrawn
- 2004-12-23 CA CA2548374A patent/CA2548374C/en not_active Expired - Fee Related
- 2004-12-23 AU AU2004303602A patent/AU2004303602C1/en not_active Ceased
- 2004-12-23 EP EP04806258A patent/EP1706385B1/en active Active
- 2004-12-23 MX MXPA06007326A patent/MXPA06007326A/es active IP Right Grant
- 2004-12-23 WO PCT/GB2004/005464 patent/WO2005061463A1/en active Application Filing
- 2004-12-23 KR KR1020067014742A patent/KR101164258B1/ko not_active IP Right Cessation
- 2004-12-23 US US10/596,788 patent/US8247576B2/en not_active Expired - Fee Related
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2005
- 2005-06-08 UY UY28946A patent/UY28946A1/es not_active Application Discontinuation
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2006
- 2006-06-08 NO NO20062633A patent/NO20062633L/no not_active Application Discontinuation
- 2006-06-19 IL IL176400A patent/IL176400A/en not_active IP Right Cessation
-
2007
- 2007-04-03 HK HK07103603.6A patent/HK1097543A1/xx not_active IP Right Cessation
-
2010
- 2010-12-07 HR HR20100675T patent/HRP20100675T1/hr unknown
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2011
- 2011-01-03 CY CY20111100002T patent/CY1111493T1/el unknown
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2012
- 2012-06-28 US US13/536,174 patent/US8691806B2/en not_active Expired - Fee Related
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2014
- 2014-02-14 US US14/180,440 patent/US9283226B2/en not_active Expired - Fee Related
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2016
- 2016-01-29 US US15/010,831 patent/US20160250187A1/en not_active Abandoned
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IL176400A (en) | 2011-10-31 |
WO2005061463A1 (en) | 2005-07-07 |
KR20060130621A (ko) | 2006-12-19 |
HK1097543A1 (en) | 2007-06-29 |
US9283226B2 (en) | 2016-03-15 |
AU2004303602C1 (en) | 2009-05-28 |
HRP20100675T1 (hr) | 2011-01-31 |
EP1706385B1 (en) | 2010-10-06 |
US20160250187A1 (en) | 2016-09-01 |
JP2007516272A (ja) | 2007-06-21 |
US8247576B2 (en) | 2012-08-21 |
UY28946A1 (es) | 2006-01-31 |
CY1111493T1 (el) | 2015-08-05 |
US20110144080A1 (en) | 2011-06-16 |
EP1706385A1 (en) | 2006-10-04 |
BRPI0418078A (pt) | 2007-04-17 |
BRPI0418078A8 (pt) | 2018-01-02 |
EP2228369A1 (en) | 2010-09-15 |
MXPA06007326A (es) | 2007-01-26 |
CA2548374A1 (en) | 2005-07-07 |
US20140271662A1 (en) | 2014-09-18 |
US20130005702A1 (en) | 2013-01-03 |
NZ547696A (en) | 2009-12-24 |
KR101164258B1 (ko) | 2012-07-11 |
PL1706385T3 (pl) | 2011-03-31 |
US8691806B2 (en) | 2014-04-08 |
JP4928949B2 (ja) | 2012-05-09 |
IL176400A0 (en) | 2006-10-05 |
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