NO20062262L - Cykloalkylderivater av 3-hydroksy-4-pyridinoner - Google Patents
Cykloalkylderivater av 3-hydroksy-4-pyridinonerInfo
- Publication number
- NO20062262L NO20062262L NO20062262A NO20062262A NO20062262L NO 20062262 L NO20062262 L NO 20062262L NO 20062262 A NO20062262 A NO 20062262A NO 20062262 A NO20062262 A NO 20062262A NO 20062262 L NO20062262 L NO 20062262L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- cycloalkyl
- group
- iron
- proviso
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer et cykloalkyl-derivat av 3-hydroksy-4-pyridinon som er anvendelige for chelatering av metallioner, så som jern. Dens fremstilling og anvendelse er beskrevet. Spesielt angår oppfinnelsen fjerning av jern i kjemiske og biologiske systemer, omfattende chelaterende midler som har formelen (I); hvor R1 er X, med det forbehold at R2 er Y; eller R1 er T, med det forbehold at R2 er W; eller R1 er X, med det forbehold at R2R5N sammen danner en heterocyklisk ring valgt fra piperidinyl, morfolinyl, pyrrolidinyl eller piperazinyl, hvor gruppen piperidinyl, morfolinyl, pyrrolidinyl eller piperazinyl enten er usubstituert eller substituert med én til tre C1- til C6-alkylgrupper. X er C3-C6-cykloalkyl; Y er valgt fra gruppen bestående av C1- til C6-cykloalkyl; C1- til C6-alkyl og C1- til C6-alkyl monosubstituert med et C3-C6-cykloalkyl; T er C1- til C6-alkyl; W er C3-C6-cykloalkyl; R3 er valgt fra gruppen bestående av hydrogen og d- til C6-alkyl; R4 er valgt fra gruppen bestående av hydrogen og C1- til C6-alkyl; R5 er valgt fra gruppen bestående av hydrogen og C1- til C6-alkyl; og dens farmasøytisk akseptabelt salt derav. Farmasøytiske preparater av slike forbindelser er anvendelige til fjerning av overskudd av jern i kroppen hos pasienter med jernbelastningssykdommer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ529657A NZ529657A (en) | 2003-11-20 | 2003-11-20 | Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
| PCT/CA2004/001986 WO2005049609A1 (en) | 2003-11-20 | 2004-11-18 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062262L true NO20062262L (no) | 2006-08-11 |
Family
ID=31987701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062262A NO20062262L (no) | 2003-11-20 | 2006-05-19 | Cykloalkylderivater av 3-hydroksy-4-pyridinoner |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7410985B2 (no) |
| EP (1) | EP1687298B1 (no) |
| KR (1) | KR101166113B1 (no) |
| CN (1) | CN100448873C (no) |
| AU (2) | AU2004291184B2 (no) |
| BR (1) | BRPI0416703A (no) |
| CA (1) | CA2546781C (no) |
| IL (1) | IL175654A (no) |
| MX (1) | MXPA06005594A (no) |
| NO (1) | NO20062262L (no) |
| NZ (1) | NZ529657A (no) |
| RU (1) | RU2345992C2 (no) |
| TN (1) | TNSN06142A1 (no) |
| UA (1) | UA84178C2 (no) |
| WO (1) | WO2005049609A1 (no) |
| ZA (1) | ZA200604998B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2488034C (en) | 2004-11-19 | 2009-10-06 | Apotex Inc. | Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues |
| DE102006043929B4 (de) * | 2006-09-14 | 2016-10-06 | Spawnt Private S.À.R.L. | Verfahren zur Herstellung von festen Polysilanmischungen |
| EP2320909B8 (en) * | 2008-07-25 | 2016-03-30 | VIIV Healthcare Company | Chemical compounds |
| CN101975767B (zh) * | 2010-08-13 | 2012-12-05 | 同济大学 | 一种测定水环境中溶解性有机物与金属离子结合潜势的方法 |
| US10064858B2 (en) * | 2011-01-31 | 2018-09-04 | The United States Of America, As Represented By The Secretary Of The Army | Methods and compositions for treating bacterial infections with iron chelators |
| CN102603964B (zh) * | 2012-01-15 | 2014-03-05 | 浙江工商大学 | 水溶性聚合物铁螯合剂及其制备方法和用途 |
| CN105030819B (zh) * | 2015-07-06 | 2019-04-05 | 中国科学技术大学 | 一种3-羟基-4-吡啶酮类高分子铁螯合剂的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308054D0 (en) * | 1983-03-24 | 1983-05-05 | Hider R C | Pharmaceutical compositions |
| GB9217099D0 (en) * | 1992-08-12 | 1992-09-23 | British Tech Group | Pharmaceutical compositions |
| ES2244967T3 (es) * | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
| US6448273B1 (en) * | 1997-05-29 | 2002-09-10 | Btg International Limited | Orally active iron (III) chelators |
| GB9711093D0 (en) * | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| US6488273B2 (en) | 2001-04-20 | 2002-12-03 | Btm Corporation | Powered pivot unit |
| US6426418B1 (en) * | 2001-11-02 | 2002-07-30 | Apotex, Inc. | Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide |
| CA2379370A1 (en) | 2002-03-28 | 2003-09-28 | Apotex Inc. | Carboxylic acid derivatives of 3-hydroxy-4-oxo-1,4-dihydropyridine as iron chelators |
-
2003
- 2003-11-20 NZ NZ529657A patent/NZ529657A/en not_active IP Right Cessation
-
2004
- 2004-11-18 AU AU2004291184A patent/AU2004291184B2/en not_active Ceased
- 2004-11-18 RU RU2006121547/04A patent/RU2345992C2/ru not_active IP Right Cessation
- 2004-11-18 MX MXPA06005594A patent/MXPA06005594A/es active IP Right Grant
- 2004-11-18 EP EP04818733A patent/EP1687298B1/en active Active
- 2004-11-18 UA UAA200606922A patent/UA84178C2/ru unknown
- 2004-11-18 CN CNB2004800392676A patent/CN100448873C/zh not_active Expired - Fee Related
- 2004-11-18 BR BRPI0416703-1A patent/BRPI0416703A/pt not_active IP Right Cessation
- 2004-11-18 CA CA2546781A patent/CA2546781C/en not_active Expired - Fee Related
- 2004-11-18 US US10/580,011 patent/US7410985B2/en not_active Expired - Fee Related
- 2004-11-18 KR KR1020067012201A patent/KR101166113B1/ko not_active IP Right Cessation
- 2004-11-18 WO PCT/CA2004/001986 patent/WO2005049609A1/en active Application Filing
-
2006
- 2006-05-15 IL IL175654A patent/IL175654A/en not_active IP Right Cessation
- 2006-05-17 TN TNP2006000142A patent/TNSN06142A1/en unknown
- 2006-05-19 NO NO20062262A patent/NO20062262L/no not_active Application Discontinuation
- 2006-06-19 ZA ZA200604998A patent/ZA200604998B/en unknown
-
2008
- 2008-05-09 US US12/149,853 patent/US8097624B2/en not_active Expired - Fee Related
-
2010
- 2010-11-19 AU AU2010246323A patent/AU2010246323A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1687298A4 (en) | 2007-10-17 |
| US7410985B2 (en) | 2008-08-12 |
| CN1926135A (zh) | 2007-03-07 |
| MXPA06005594A (es) | 2006-12-19 |
| TNSN06142A1 (en) | 2007-11-15 |
| CA2546781A1 (en) | 2005-06-02 |
| UA84178C2 (en) | 2008-09-25 |
| EP1687298B1 (en) | 2012-12-26 |
| CA2546781C (en) | 2012-05-15 |
| KR101166113B1 (ko) | 2012-07-27 |
| KR20060096155A (ko) | 2006-09-07 |
| AU2004291184B2 (en) | 2010-08-26 |
| AU2004291184A1 (en) | 2005-06-02 |
| RU2006121547A (ru) | 2007-12-27 |
| BRPI0416703A (pt) | 2007-01-16 |
| IL175654A0 (en) | 2006-09-05 |
| NZ529657A (en) | 2004-07-30 |
| ZA200604998B (en) | 2007-09-26 |
| US20070082904A1 (en) | 2007-04-12 |
| AU2010246323A1 (en) | 2010-12-09 |
| CN100448873C (zh) | 2009-01-07 |
| IL175654A (en) | 2011-10-31 |
| US20090170850A1 (en) | 2009-07-02 |
| US8097624B2 (en) | 2012-01-17 |
| RU2345992C2 (ru) | 2009-02-10 |
| WO2005049609A1 (en) | 2005-06-02 |
| EP1687298A1 (en) | 2006-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |