NO20052312L - Kombinasjonsprodukt av inhibitor fra SRC-familien av ikke-reseptor-tyrosinkinaser og gemcitabin. - Google Patents
Kombinasjonsprodukt av inhibitor fra SRC-familien av ikke-reseptor-tyrosinkinaser og gemcitabin.Info
- Publication number
- NO20052312L NO20052312L NO20052312A NO20052312A NO20052312L NO 20052312 L NO20052312 L NO 20052312L NO 20052312 A NO20052312 A NO 20052312A NO 20052312 A NO20052312 A NO 20052312A NO 20052312 L NO20052312 L NO 20052312L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitor
- gemcitabine
- receptor tyrosine
- tyrosine kinases
- combination product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Oppfinnelsen angår en kombinasjon som omfatter en inhibitor av Src-kinase og det cytotoksiske midlet gemcitabin, et farmasøytisk preparat som omfatter en slik kombinasjon, og dets anvendelse ved behandling eller forebygging av kreft, spesielt pankreaskreft.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0226434.9A GB0226434D0 (en) | 2002-11-13 | 2002-11-13 | Combination product |
PCT/GB2003/004787 WO2004043472A1 (en) | 2002-11-13 | 2003-11-07 | Combination product of inhibitor of the src family of non-receptor tyrosine kinases and gemcitabine |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20052312L true NO20052312L (no) | 2005-06-06 |
Family
ID=9947715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20052312A NO20052312L (no) | 2002-11-13 | 2005-05-11 | Kombinasjonsprodukt av inhibitor fra SRC-familien av ikke-reseptor-tyrosinkinaser og gemcitabin. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060142297A1 (no) |
EP (1) | EP1562612B1 (no) |
JP (1) | JP2006508953A (no) |
KR (1) | KR20050074573A (no) |
CN (1) | CN100467027C (no) |
AT (1) | ATE456370T1 (no) |
AU (1) | AU2003279456B2 (no) |
BR (1) | BR0316170A (no) |
CA (1) | CA2504666A1 (no) |
DE (1) | DE60331162D1 (no) |
ES (1) | ES2338109T3 (no) |
GB (1) | GB0226434D0 (no) |
NO (1) | NO20052312L (no) |
NZ (1) | NZ539514A (no) |
WO (1) | WO2004043472A1 (no) |
ZA (1) | ZA200503805B (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2318649T3 (es) | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento de preparacion de derivados de 4-fenoxi quinolinas. |
GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
US7462623B2 (en) | 2002-11-04 | 2008-12-09 | Astrazeneca Ab | Quinazoline derivatives as Src tyrosine kinase inhibitors |
JPWO2004080462A1 (ja) | 2003-03-10 | 2006-06-08 | エーザイ株式会社 | c−Kitキナーゼ阻害剤 |
GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
JP4303726B2 (ja) | 2003-11-11 | 2009-07-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウレア誘導体およびその製造方法 |
GB0412074D0 (en) | 2004-05-29 | 2004-06-30 | Astrazeneca Ab | Combination product |
ES2322175T3 (es) | 2004-09-17 | 2009-06-17 | EISAI R&D MANAGEMENT CO., LTD. | Composicion medicinal con estabilidad mejorada y gelificacion reducida. |
GB0427697D0 (en) * | 2004-12-17 | 2005-01-19 | Astrazeneca Ab | Chemical process |
US9006240B2 (en) | 2005-08-02 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
CN104706637A (zh) | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
EP2065372B1 (en) | 2006-08-28 | 2012-11-28 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
CA2675736A1 (en) | 2007-01-19 | 2008-07-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of pancreatic cancer |
WO2008093855A1 (ja) | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
EP2218712B1 (en) | 2007-11-09 | 2015-07-01 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
JP5898074B2 (ja) | 2010-06-25 | 2016-04-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤 |
CA2828946C (en) | 2011-04-18 | 2016-06-21 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
EP2714937B1 (en) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
AR092289A1 (es) | 2011-11-14 | 2015-04-15 | Sunshine Lake Pharma Co Ltd | Derivados de aminoquinazolina y sus sales y metodos de uso |
WO2013152313A1 (en) * | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Compositions and methods for treating cancer and diseases and conditions responsive to growth factor inhibition |
KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
WO2014185540A1 (en) | 2013-05-14 | 2014-11-20 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
KR102329681B1 (ko) | 2014-08-28 | 2021-11-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고순도의 퀴놀린 유도체 및 이를 제조하는 방법 |
CA2976325C (en) | 2015-02-25 | 2023-07-04 | Eisai R&D Management Co., Ltd. | Method for suppressing bitterness of quinoline derivative |
KR20240064733A (ko) | 2015-03-04 | 2024-05-13 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
US20170022576A1 (en) | 2015-03-18 | 2017-01-26 | The Regents Of The University Of California | Compositions and methods for identifying anti-cancer, anti-metastatic and anti-stress agents |
RU2729936C2 (ru) | 2015-06-16 | 2020-08-13 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противораковое средство |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
PT1115391E (pt) * | 1998-09-25 | 2003-02-28 | Warner Lambert Co | Quimioterapia do cancro com acetildinalina em combinacao com gemcitabina capecitabina ou cisplatina |
ATE253915T1 (de) * | 1999-06-30 | 2003-11-15 | Merck & Co Inc | Src-kinase hemmende verbindungen |
US6503914B1 (en) * | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
GB0412074D0 (en) * | 2004-05-29 | 2004-06-30 | Astrazeneca Ab | Combination product |
-
2002
- 2002-11-13 GB GBGB0226434.9A patent/GB0226434D0/en not_active Ceased
-
2003
- 2003-11-07 JP JP2004550784A patent/JP2006508953A/ja active Pending
- 2003-11-07 NZ NZ539514A patent/NZ539514A/en unknown
- 2003-11-07 US US10/534,721 patent/US20060142297A1/en not_active Abandoned
- 2003-11-07 ES ES03772404T patent/ES2338109T3/es not_active Expired - Lifetime
- 2003-11-07 BR BR0316170-6A patent/BR0316170A/pt not_active IP Right Cessation
- 2003-11-07 CN CNB2003801031384A patent/CN100467027C/zh not_active Expired - Fee Related
- 2003-11-07 WO PCT/GB2003/004787 patent/WO2004043472A1/en active IP Right Grant
- 2003-11-07 DE DE60331162T patent/DE60331162D1/de not_active Expired - Lifetime
- 2003-11-07 AU AU2003279456A patent/AU2003279456B2/en not_active Ceased
- 2003-11-07 CA CA002504666A patent/CA2504666A1/en not_active Abandoned
- 2003-11-07 AT AT03772404T patent/ATE456370T1/de not_active IP Right Cessation
- 2003-11-07 KR KR1020057008291A patent/KR20050074573A/ko not_active Application Discontinuation
- 2003-11-07 EP EP03772404A patent/EP1562612B1/en not_active Expired - Lifetime
-
2005
- 2005-05-11 ZA ZA200503805A patent/ZA200503805B/en unknown
- 2005-05-11 NO NO20052312A patent/NO20052312L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2504666A1 (en) | 2004-05-27 |
KR20050074573A (ko) | 2005-07-18 |
AU2003279456A1 (en) | 2004-06-03 |
BR0316170A (pt) | 2005-09-27 |
JP2006508953A (ja) | 2006-03-16 |
CN1711094A (zh) | 2005-12-21 |
ZA200503805B (en) | 2006-09-27 |
DE60331162D1 (de) | 2010-03-18 |
EP1562612B1 (en) | 2010-01-27 |
CN100467027C (zh) | 2009-03-11 |
ES2338109T3 (es) | 2010-05-04 |
EP1562612A1 (en) | 2005-08-17 |
AU2003279456B2 (en) | 2007-05-17 |
WO2004043472A1 (en) | 2004-05-27 |
ATE456370T1 (de) | 2010-02-15 |
GB0226434D0 (en) | 2002-12-18 |
US20060142297A1 (en) | 2006-06-29 |
NZ539514A (en) | 2007-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |