NO20050074L - Modulatorer for glukocorticoidreseptoren og metode - Google Patents

Modulatorer for glukocorticoidreseptoren og metode

Info

Publication number
NO20050074L
NO20050074L NO20050074A NO20050074A NO20050074L NO 20050074 L NO20050074 L NO 20050074L NO 20050074 A NO20050074 A NO 20050074A NO 20050074 A NO20050074 A NO 20050074A NO 20050074 L NO20050074 L NO 20050074L
Authority
NO
Norway
Prior art keywords
glucocorticoid receptor
modulators
obesity
diabetes
inflammatory
Prior art date
Application number
NO20050074A
Other languages
English (en)
Norwegian (no)
Inventor
David R Tortolani
Soong-Hoon Kim
Arthur M Doweyko
Wenying Li
Wayne D Vaccaro
Bingwei Vera Yang
Tram Huynh
Kenneth J Leavitt
Lidia Doweyko
Xiao-Tao Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20050074L publication Critical patent/NO20050074L/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003251970A1 (en) * 2002-07-18 2004-02-09 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
EP1575502B1 (fr) 2002-07-18 2010-01-20 Bristol-Myers Squibb Company Compositions et procedes impliquant le site ii des recepteurs nucleaires d'hormones (nhr)
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
WO2005012263A1 (fr) * 2003-07-24 2005-02-10 Pharmagene Laboratories Limited Antagonistes du recepteur 5-ht2b
US7569689B2 (en) * 2004-01-16 2009-08-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7253283B2 (en) * 2004-01-16 2007-08-07 Bristol-Myers Squibb Company Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7326728B2 (en) 2004-01-16 2008-02-05 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
US7605264B2 (en) 2004-01-16 2009-10-20 Bristol-Myers Squibb Company Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7625921B2 (en) * 2004-01-16 2009-12-01 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7273881B2 (en) * 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2005097113A2 (fr) * 2004-04-08 2005-10-20 Pharmagene Laboratories Limited Antagonistes du recepteur de la 5-ht2b
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
CA2575466A1 (fr) * 2004-08-13 2006-02-23 Genentech, Inc. Composes a base de 2-amido-thiazole presentant une activite inhibitrice enzymatique utilisant de l'adenosine triphosphate (atp), et compositions, et leurs utilisations
US7579335B2 (en) 2005-01-10 2009-08-25 Glaxo Group Limited Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
US7642273B2 (en) * 2005-01-13 2010-01-05 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7411071B2 (en) 2005-01-13 2008-08-12 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7317024B2 (en) 2005-01-13 2008-01-08 Bristol-Myers Squibb Co. Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7361654B2 (en) 2005-01-13 2008-04-22 Bristol-Myers Squibb Co. Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
PE20100737A1 (es) 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
AR053450A1 (es) 2005-03-25 2007-05-09 Glaxo Group Ltd Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
KR20080040677A (ko) * 2005-06-24 2008-05-08 제네랩스 테크놀로지스, 인코포레이티드 바이러스를 치료하기 위한 헤테로아릴 유도체
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
TWI375676B (en) * 2005-08-29 2012-11-01 Msd Oss Bv Non-steroidal glucocorticoid receptor modulators
PE20071068A1 (es) 2005-12-20 2007-12-13 Glaxo Group Ltd Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
PE20071227A1 (es) 2006-04-20 2008-02-18 Glaxo Group Ltd Compuestos derivados de indazol como moduladores del receptor de glucocorticoides
GB0611587D0 (en) 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
EP2494967A1 (fr) * 2007-01-16 2012-09-05 Ipintl, Llc Nouvelle composition pour le traitement du syndrôme métabolique
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
CA2666036C (fr) * 2008-05-16 2017-09-12 Chien-Hung Chen Compositions inedites et methodes de traitement des maladies hyperproliferantes
SG190667A1 (en) 2008-05-23 2013-06-28 Panmira Pharmaceuticals Llc 5-lipoxygenase-activating protein inhibitor
JP5502077B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド 新規な化合物
JP5502858B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド Ｐｉ３キナーゼの阻害剤として有用な４−カルボキサミドインダゾール誘導体
EP3607942A1 (fr) 2008-11-07 2020-02-12 University of Sheffield Médicament et procédé de diagnostic
WO2010094643A1 (fr) 2009-02-17 2010-08-26 Glaxo Group Limited Dérivés de quinoline et applications associées dans la rhinite et l'urticaire
WO2010102958A1 (fr) 2009-03-09 2010-09-16 Glaxo Group Limited 4-oxadiazol-2-yl-indazoles en tant qu'inhibiteurs des p13 kinases
EP2406249A1 (fr) 2009-03-10 2012-01-18 Glaxo Group Limited Dérivés d'indole comme inhibiteurs de ikk2
US8377947B2 (en) * 2009-03-16 2013-02-19 Chien-Hung Chen Treating alzheimer's disease and osteoporosis and reducing aging
US20120058984A1 (en) 2009-03-17 2012-03-08 Catherine Mary Alder Pyrimidine derivatives used as itk inhibitors
EP2408916A2 (fr) 2009-03-19 2012-01-25 Merck Sharp&Dohme Corp. Inhibition médiée par arn interférence de l'expression génique de facteur de croissance de tissu conjonctif (ctgf) en utilisant un acide nucléique interférant court (ansi)
WO2010107957A2 (fr) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. Inhibition induite par arn interférence d'une expression génique (gata3) d'une protéine de liaison gata au moyen d'un acide nucléique interférent court
EP2408917A2 (fr) 2009-03-19 2012-01-25 Merck Sharp&Dohme Corp. Inhibition médiée par arn interférence de l'expression génique de btb et de l'homologie cnc 1, facteur de transcription 1 de fermeture éclair de leucine basique (bach 1), utilisant une liste de séquences d'acide nucléique interférant court (ansi)
US20120035247A1 (en) 2009-03-19 2012-02-09 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
JP2012521764A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いた胸腺間質性リンパ球新生因子（ＴＳＬＰ）遺伝子発現のＲＮＡ干渉媒介性阻害
JP2012521760A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたアポトーシスシグナル調節キナーゼ１（ＡＳＫ１）遺伝子発現のＲＮＡ干渉媒介性阻害
US20120004281A1 (en) 2009-03-27 2012-01-05 Merck Sharp & Dohme Corp RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA)
WO2010111471A2 (fr) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. Inhibition par interférence arn de l'expression du gène du signal transducteur et activateur de la transcription 1 (stat1) au moyen d'un acide nucléique interférent court (ansi)
EP2411517A2 (fr) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi)
US20120035237A1 (en) 2009-04-24 2012-02-09 Diane Mary Coe Pyrazole and triazole carboxamides as crac chann el inhibitors
EP2421835A1 (fr) 2009-04-24 2012-02-29 Glaxo Group Limited Carboxamides n-pyrazolyl en tant qu'inhibiteurs du canal crac
ME02900B (fr) 2009-04-30 2018-04-20 Glaxo Group Ltd Nouveaux composés
WO2011067364A1 (fr) 2009-12-03 2011-06-09 Glaxo Group Limited Nouveaux composés
JP2013512879A (ja) 2009-12-03 2013-04-18 グラクソ グループ リミテッド Ｐｉ３キナーゼの阻害剤としてのベンズピラゾール誘導体
US20120238571A1 (en) 2009-12-03 2012-09-20 Glaxo Group Limited Indazole derivatives as pi 3-kinase
EP3020393B1 (fr) 2009-12-16 2020-10-07 3M Innovative Properties Company Formulations et procédés de commande de distribution granulométrique mdi
WO2011110575A1 (fr) 2010-03-11 2011-09-15 Glaxo Group Limited Dérivés de 2-[2-(benzo- ou pyrido-)thiazolylamino]-6- aminopyridine, utiles dans le traitement de maladies respiratoires, allergiques ou inflammatoires
GB201007203D0 (en) 2010-04-29 2010-06-16 Glaxo Group Ltd Novel compounds
MX2013001313A (es) 2010-08-05 2013-06-13 Amgen Inc Compuestos de bencimidazol y azabencimidazol que inhiben la cinasa del linfoma anaplasico.
US9326987B2 (en) 2010-09-08 2016-05-03 Glaxo Group Limited Indazole derivatives for use in the treatment of influenza virus infection
JP5965402B2 (ja) 2010-09-08 2016-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎ−［５−［４−（５−｛［（２ｒ，６ｓ）−２，６−ジメチル−４−モルホリニル］メチル｝−１，３−オキサゾール−２−イル）−１ｈ−インダゾール−６−イル］−２−（メチルオキシ）−３−ピリジニル］メタンスルホンアミドの多形体および塩
WO2012035055A1 (fr) 2010-09-17 2012-03-22 Glaxo Group Limited Nouveaux composés
ES2532213T3 (es) 2010-10-21 2015-03-25 Glaxo Group Limited Compuestos de pirazol que actúan contra afecciones alérgicas, inmunitarias e inflamatorias
EP2630127A1 (fr) 2010-10-21 2013-08-28 Glaxo Group Limited Composés de pyrazole agissant contre des troubles allergiques, inflammatoires et immunitaires
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
JP2014507458A (ja) 2011-03-11 2014-03-27 グラクソ グループ リミテッド Ｓｙｋインヒビターとしてのピリド［３，４−Ｂ］ピラジン誘導体
CN103058949A (zh) * 2011-10-18 2013-04-24 华东理工大学 做为dhodh抑制剂的噻唑衍生物及其应用
WO2014121055A2 (fr) * 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Modulateurs flap
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CN105492444B (zh) 2013-07-02 2018-09-07 百时美施贵宝公司 作为rock抑制剂的三环吡啶-甲酰胺衍生物
ES2634628T3 (es) 2013-07-02 2017-09-28 Bristol-Myers Squibb Company Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK
MX2016003456A (es) 2013-09-22 2017-05-25 Calitor Sciences Llc Compuestos aminopirimidina sustituidos y metodos de uso.
JP2016537327A (ja) 2013-10-17 2016-12-01 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 呼吸器疾患の治療のためのｐｉ３ｋ阻害剤
RU2016112266A (ru) 2013-10-17 2017-11-20 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Ингибитор PI3K для лечения респираторного заболевания
EP3312164B1 (fr) 2014-03-28 2020-12-09 Calitor Sciences, LLC Composés d'hétéroaryle substitués et procédés d'utilisation
CN107072976A (zh) 2014-05-12 2017-08-18 葛兰素史克知识产权第二有限公司 用于治疗传染性疾病的包含Danirixin的药物组合物
SG11201703024VA (en) 2014-10-15 2017-05-30 Corcept Therapeutics Inc Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists
US9938257B2 (en) 2015-09-11 2018-04-10 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
GB201602527D0 (en) 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
EP3484528B1 (fr) 2016-07-18 2020-11-25 Janssen Pharmaceutica NV Ligands d'imagerie tep pour la protéine tau
EP3497100A1 (fr) 2016-08-08 2019-06-19 GlaxoSmithKline Intellectual Property Development Limited Composés chimiques
GB201706102D0 (en) 2017-04-18 2017-05-31 Glaxosmithkline Ip Dev Ltd Chemical compounds
GB201712081D0 (en) 2017-07-27 2017-09-13 Glaxosmithkline Ip Dev Ltd Chemical compounds
WO2019099311A1 (fr) 2017-11-19 2019-05-23 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryle substitués et leurs méthodes d'utilisation
CA3083040A1 (fr) 2018-01-20 2019-07-25 Sunshine Lake Pharma Co., Ltd. Composes d'aminopyrimidine substitues et procedes d'utilisation
BR112022019245A2 (pt) 2020-03-26 2022-11-16 Glaxosmithkline Ip Dev Ltd Inibidores de catepsina para prevenir ou tratar infecções virais
CN112336719A (zh) * 2020-10-19 2021-02-09 济南大学 一种噻唑衍生物作为α-葡萄糖苷酶抑制剂及其应用
CN115974723A (zh) * 2022-12-27 2023-04-18 中国药科大学 甲酰胺乙撑蒽类化合物、包含其的药物组合物及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123295C (fr) * 1963-10-21
FR1451562A (fr) * 1965-07-23 1966-01-07 Soc Ind Fab Antibiotiques Sifa Nouvelles alcoylènediamines dérivées de l'éthano-9, 10 anthracène et leurs sels, et procédé de préparation
US4786646A (en) 1987-07-10 1988-11-22 Hoffmann-La Roche Inc. Cyclopropylpropenamides
DK0405436T3 (da) 1989-06-29 1995-12-11 Searle & Co Dihetero-nitrogen-holdige cycloheteroethanoanthracenderivater som antipsykotiske midler
US5055468A (en) 1989-10-30 1991-10-08 G. D. Searle & Co. Use of bridged tricyclic amine derivatives as anti-ischemic agents
US5332820A (en) 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
GB9316722D0 (en) * 1993-08-12 1993-09-29 Black James Foundation Bicyclo (2.2.2)octane derivatives
HUT71499A (en) 1992-02-20 1995-11-28 Black James Foundation Bicyclo[2.2.2.]octane derivatives pharmaceutical compositions contg. the said compounds and process to prepare them
US5514683A (en) 1992-02-20 1996-05-07 James Black Foundation Limited Bicyclo 2,2,2!octane derivatives
MX9303670A (es) 1992-06-19 1994-05-31 Black James Foundation Derivados de biciclooctano y bicicloheptano, meto do para su preparacion y composiciones farmaceuticas que los contienen.
US5461054A (en) 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
US5409932A (en) 1993-12-09 1995-04-25 Bayer Ag Piperazine-substituted pyrroloanthracenes
US5411960A (en) 1993-12-09 1995-05-02 Bayer Aktiengesellschaft Substituted pyrroloanthracenes and -diones
EP0727410A1 (fr) 1995-02-08 1996-08-21 Ciba-Geigy Ag Dérivés esters du bisphénol
US6262059B1 (en) 1995-06-07 2001-07-17 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with quinazoline derivatives
DE19742014A1 (de) 1997-09-24 1999-03-25 Roche Diagnostics Gmbh Neue Tetracyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6214915B1 (en) 1998-12-10 2001-04-10 General Electric Company Stabilized thermoplastic compositions
ATE303369T1 (de) * 2000-10-30 2005-09-15 Pfizer Prod Inc Glucocorticoid rezeptor modulatoren
AU2003251970A1 (en) * 2002-07-18 2004-02-09 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method

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US20040132758A1 (en) 2004-07-08
US20050171136A1 (en) 2005-08-04
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