NO20044039L - Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider. - Google Patents
Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider.Info
- Publication number
- NO20044039L NO20044039L NO20044039A NO20044039A NO20044039L NO 20044039 L NO20044039 L NO 20044039L NO 20044039 A NO20044039 A NO 20044039A NO 20044039 A NO20044039 A NO 20044039A NO 20044039 L NO20044039 L NO 20044039L
- Authority
- NO
- Norway
- Prior art keywords
- therapeutic
- biologically active
- cytotoxic agents
- conjugators
- active peptides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36083102P | 2002-03-01 | 2002-03-01 | |
| PCT/US2003/006657 WO2003074551A2 (fr) | 2002-03-01 | 2003-03-03 | Conjugues d'agents therapeutiques ou cytotoxiques et de peptides bioactifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20044039L true NO20044039L (no) | 2004-09-29 |
Family
ID=27789031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20044039A NO20044039L (no) | 2002-03-01 | 2004-09-24 | Konjugatorer av terapeutiske eller cytotoksiske midler og biologisk aktive peptider. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7771727B2 (fr) |
| EP (1) | EP1487493B1 (fr) |
| JP (1) | JP4477881B2 (fr) |
| KR (1) | KR101003622B1 (fr) |
| CN (2) | CN1649625A (fr) |
| AT (1) | ATE455561T1 (fr) |
| AU (1) | AU2003220011B2 (fr) |
| BR (1) | BR0308090A (fr) |
| CA (1) | CA2476182A1 (fr) |
| CO (1) | CO5611160A2 (fr) |
| DE (1) | DE60331049D1 (fr) |
| DK (1) | DK1487493T3 (fr) |
| ES (1) | ES2339934T3 (fr) |
| IL (1) | IL163573A0 (fr) |
| IS (1) | IS7431A (fr) |
| MX (1) | MXPA04008419A (fr) |
| NO (1) | NO20044039L (fr) |
| NZ (1) | NZ534719A (fr) |
| PL (1) | PL373567A1 (fr) |
| WO (1) | WO2003074551A2 (fr) |
| ZA (1) | ZA200406614B (fr) |
Families Citing this family (67)
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|---|---|---|---|---|
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| KR101064901B1 (ko) * | 2003-03-20 | 2011-09-16 | 나노캐리어 가부시키가이샤 | 난수용성 항암제와 신규 블록 공중합체를 포함하는 미셀조제물 |
| AU2003225410A1 (en) * | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| AU2004232314B2 (en) * | 2003-04-22 | 2007-11-22 | Ipsen Pharma S.A.S. | Peptide vectors |
| US20060281897A1 (en) * | 2003-08-22 | 2006-12-14 | Andre Trouet | Potentialization of the activation of high molecular weight prodrugs |
| US9011880B2 (en) | 2003-10-21 | 2015-04-21 | Igf Oncology, Llc | Compounds and methods for treating cancer |
| CA2542834C (fr) | 2003-10-21 | 2012-04-24 | Igf Oncology, Llc | Conjugues ou co-administration de ligands du recepteur igf-1 et d'agents chimiotherapeutiques anticancereux |
| CA2581125C (fr) * | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Nouveau copolymere en blocs, preparation de micelles et agent anticancereux contenant celle-ci comme ingredient actif |
| EP1812082B1 (fr) | 2004-10-21 | 2013-08-14 | IGF Oncology, LLC | Toxines et radionucléides couplés à des ligands du récepteur IGF-1 pour le traitment du cancer |
| US8067376B2 (en) * | 2004-11-03 | 2011-11-29 | Forhumantech Co., Ltd. | Pharmaceutical compositions for transdermal delivery |
| CA2617953C (fr) * | 2005-08-09 | 2013-12-17 | Millennium Pharmaceuticals, Inc. | Procede d'acylation de maytansinol a l'aide d'aminoacides chiraux |
| WO2007123391A1 (fr) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Intervention thérapeutique dans une maladie génétique chez un individu en modifiant l'expression d'un gène exprimé de manière aberrante. |
| US8940332B2 (en) * | 2006-05-18 | 2015-01-27 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
| EP1857548A1 (fr) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Procédé et moyen permettant d'induire un saut d'exon |
| EP2046954A2 (fr) | 2006-07-31 | 2009-04-15 | Curevac GmbH | Acide nucléique de formule (i): gixmgn, ou(ii): cixmcn, en particulier en tant qu'agent/adjuvant immunostimulant |
| WO2008018795A1 (fr) | 2006-08-11 | 2008-02-14 | Prosensa Technologies B.V. | Procédés et moyens de traitement de troubles génétiques associés à l'instabilité des répétitions de l'ADN |
| CA2664852A1 (fr) * | 2006-10-03 | 2008-04-10 | Nippon Kayaku Kabushiki Kaisha | Melange d'un derive de resorcinol avec un polymere |
| EP2167135A2 (fr) | 2007-07-12 | 2010-03-31 | Prosensa Technologies B.V. | Molécules pour cibler les composants vers plusieurs organes sélectionnés, tissus ou cellules de tumeurs |
| DK2167136T3 (en) * | 2007-07-12 | 2016-07-25 | Biomarin Tech Bv | Molecules for targeting compounds at different selected organs or tissues |
| WO2009030254A1 (fr) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes d'arn et de peptides cationiques pour transfection et immunostimulation |
| JP5349318B2 (ja) | 2007-09-28 | 2013-11-20 | 日本化薬株式会社 | ステロイド類の高分子結合体 |
| NZ584793A (en) | 2007-10-26 | 2012-05-25 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| PT2176408E (pt) | 2008-01-31 | 2015-04-23 | Curevac Gmbh | Ácidos nucleicos compreendendo a fórmula (nuglxmgnnv)a e os seus derivados como agentes/adjuvantes imunoestimuladores |
| NZ587178A (en) | 2008-02-08 | 2011-11-25 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
| WO2009116509A1 (fr) * | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | Conjugué de polymère et de substance physiologiquement active |
| WO2009136572A1 (fr) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | Conjugué de polymère avec l'acide folique ou un dérivé de l'acide folique |
| EP2119783A1 (fr) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Procédé pour l'omission efficace de l'exon (44) dans la dystrophie musculaire de Duchenne et moyens connexes |
| WO2010037408A1 (fr) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprenant un arnm complexé et un arnm nu pour déclencher ou augmenter une réponse immunostimulante chez un mammifère et utilisations de ladite composition |
| CN101439182B (zh) * | 2008-12-18 | 2012-02-01 | 北京大学 | 一种生长抑素受体介导的肿瘤靶向药物组合物 |
| WO2010096394A2 (fr) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Véhicules de médicaments à base de protéine marqués par aldéhyde et procédés d'utilisation |
| JP2012524540A (ja) | 2009-04-24 | 2012-10-18 | プロセンサ テクノロジーズ ビー．ブイ． | Ｄｍｄを処置するためのイノシンを含むオリゴヌクレオチド |
| CN102421827B (zh) | 2009-05-15 | 2014-07-30 | 日本化药株式会社 | 具有羟基的生理活性物质的高分子结合体 |
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| AU2010335039B2 (en) | 2009-12-24 | 2015-03-26 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Molecule for treating an inflammatory disorder |
| US8968746B2 (en) | 2010-07-30 | 2015-03-03 | Curevac Gmbh | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| CA2816997A1 (fr) | 2010-11-17 | 2012-05-24 | Nippon Kayaku Kabushiki Kaisha | Nouveau derive polymere d'antagoniste de metabolisme de cytidine |
| CN103415621A (zh) | 2011-01-14 | 2013-11-27 | 雷德伍德生物科技股份有限公司 | 醛标记免疫球蛋白多肽及其使用方法 |
| CN103501823B (zh) | 2011-02-17 | 2018-05-04 | 杜兰教育基金委员会 | 多组分组合物以及它们的用途 |
| BR112014005452B1 (pt) | 2011-09-11 | 2021-03-16 | Nippon Kayaku Kabushiki Kaisha | método de produção de copolímero de bloco |
| EP2806900B1 (fr) | 2012-01-27 | 2021-12-15 | BioMarin Technologies B.V. | Oligonucléotides de modulation arn ayant des caractéristiques améliorées pour le traitement de la dystrophie musculaire de duchenne et becker |
| WO2013113326A1 (fr) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Composition pharmaceutique comprenant un complexe support polymère - charge et au moins un antigène de protéine ou de peptide |
| CN104470544B (zh) * | 2012-05-01 | 2018-01-12 | 基因泰克公司 | 抗pmel17抗体和免疫缀合物 |
| EP2849790B1 (fr) * | 2012-05-15 | 2019-04-10 | Concortis Biosystems, Corp | Conjugués de médicament, procédés de conjugaison, et utilisations associées |
| AU2014233385C1 (en) * | 2013-03-15 | 2019-09-19 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| CN105473158B (zh) | 2013-08-21 | 2021-04-13 | 库瑞瓦格股份公司 | 呼吸道合胞病毒(rsv)疫苗 |
| WO2015106224A2 (fr) | 2014-01-12 | 2015-07-16 | Hugh Mctavish | Protéines de fusion contenant un facteur-1 de croissance de type insuline et un facteur de croissance épidermique et leurs variantes, et leurs utilisations |
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| CN105198966B (zh) * | 2014-06-26 | 2019-06-21 | 中国人民解放军军事医学科学院毒物药物研究所 | GnRH类似物-细胞毒分子缀合物、其制备方法及用途 |
| BR212016030926U2 (pt) | 2014-06-30 | 2018-05-29 | Tarveda Therapeutics Inc | conjugados de alvo e partículas e formulações dos mesmos |
| AU2015299055C1 (en) * | 2014-08-06 | 2021-05-06 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
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| WO2019034176A1 (fr) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | Conjugué de camptothécine-anticorps |
| US11419951B2 (en) * | 2017-08-19 | 2022-08-23 | Ohio State Innovation Foundation | Peptide-based cancer imaging agents |
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-
2003
- 2003-03-03 NZ NZ534719A patent/NZ534719A/en not_active IP Right Cessation
- 2003-03-03 CA CA002476182A patent/CA2476182A1/fr not_active Abandoned
- 2003-03-03 EP EP03716299A patent/EP1487493B1/fr not_active Expired - Lifetime
- 2003-03-03 CN CNA038099276A patent/CN1649625A/zh active Pending
- 2003-03-03 BR BRPI0308090-0A patent/BR0308090A/pt not_active IP Right Cessation
- 2003-03-03 US US10/506,223 patent/US7771727B2/en not_active Expired - Fee Related
- 2003-03-03 DE DE60331049T patent/DE60331049D1/de not_active Expired - Lifetime
- 2003-03-03 WO PCT/US2003/006657 patent/WO2003074551A2/fr active Application Filing
- 2003-03-03 PL PL03373567A patent/PL373567A1/xx not_active Application Discontinuation
- 2003-03-03 DK DK03716299.7T patent/DK1487493T3/da active
- 2003-03-03 JP JP2003573017A patent/JP4477881B2/ja not_active Expired - Lifetime
- 2003-03-03 AT AT03716299T patent/ATE455561T1/de active
- 2003-03-03 KR KR1020047013597A patent/KR101003622B1/ko not_active IP Right Cessation
- 2003-03-03 CN CN2010106215969A patent/CN102133407A/zh active Pending
- 2003-03-03 AU AU2003220011A patent/AU2003220011B2/en not_active Ceased
- 2003-03-03 IL IL16357303A patent/IL163573A0/xx unknown
- 2003-03-03 MX MXPA04008419A patent/MXPA04008419A/es active IP Right Grant
- 2003-03-03 ES ES03716299T patent/ES2339934T3/es not_active Expired - Lifetime
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2004
- 2004-08-19 ZA ZA200406614A patent/ZA200406614B/en unknown
- 2004-08-31 IS IS7431A patent/IS7431A/is unknown
- 2004-09-24 NO NO20044039A patent/NO20044039L/no not_active Application Discontinuation
- 2004-09-29 CO CO04097209A patent/CO5611160A2/es not_active Application Discontinuation
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2009
- 2009-08-25 US US12/547,096 patent/US20090324620A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7771727B2 (en) | 2010-08-10 |
| CO5611160A2 (es) | 2006-02-28 |
| MXPA04008419A (es) | 2004-11-26 |
| IS7431A (is) | 2004-08-31 |
| BR0308090A (pt) | 2006-04-11 |
| WO2003074551A8 (fr) | 2005-11-03 |
| DK1487493T3 (da) | 2010-05-25 |
| CA2476182A1 (fr) | 2003-09-12 |
| KR101003622B1 (ko) | 2010-12-24 |
| CN1649625A (zh) | 2005-08-03 |
| ZA200406614B (en) | 2006-06-28 |
| WO2003074551A2 (fr) | 2003-09-12 |
| US20090324620A1 (en) | 2009-12-31 |
| AU2003220011A1 (en) | 2003-09-16 |
| EP1487493B1 (fr) | 2010-01-20 |
| CN102133407A (zh) | 2011-07-27 |
| AU2003220011B2 (en) | 2008-05-29 |
| KR20040088568A (ko) | 2004-10-16 |
| EP1487493A4 (fr) | 2006-08-30 |
| ES2339934T3 (es) | 2010-05-27 |
| IL163573A0 (en) | 2005-12-18 |
| WO2003074551A3 (fr) | 2004-03-25 |
| EP1487493A2 (fr) | 2004-12-22 |
| DE60331049D1 (de) | 2010-03-11 |
| ATE455561T1 (de) | 2010-02-15 |
| PL373567A1 (en) | 2005-09-05 |
| JP4477881B2 (ja) | 2010-06-09 |
| US20060009622A1 (en) | 2006-01-12 |
| JP2006510571A (ja) | 2006-03-30 |
| NZ534719A (en) | 2008-02-29 |
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