NO20041431L - Tetrahydrofuranderivater og anvendelse av disse som terapeutiske midler - Google Patents

Tetrahydrofuranderivater og anvendelse av disse som terapeutiske midler

Info

Publication number
NO20041431L
NO20041431L NO20041431A NO20041431A NO20041431L NO 20041431 L NO20041431 L NO 20041431L NO 20041431 A NO20041431 A NO 20041431A NO 20041431 A NO20041431 A NO 20041431A NO 20041431 L NO20041431 L NO 20041431L
Authority
NO
Norway
Prior art keywords
sup
sub
therapeutic agents
tetrahydrofuran derivatives
replaced
Prior art date
Application number
NO20041431A
Other languages
English (en)
Inventor
Brian John Williams
Jose Luis Castro Pineiro
Duncan Edward Shaw
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO20041431L publication Critical patent/NO20041431L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Oppfinnelsen angår forbindelser med formel (I) hvor R, R, R, R,, R,,og R10 representerer forskjellige substituenter; A representerer NReller O; B representerer en binding, CH, NReller O, hvor ett eller begge hydrogenatomer i CH-gruppen kan være erstattet med én eller begge av Rog R, eller alternativt kan hydrogenatomene i CH-gruppen sammen med et hydrogenatom fra et nabo-karbonatom erstattes med en dobbeltbinding; under den forutsetning at når A er O, så er B lik NR; n er 0, 1 eller 2; og farmasøytisk akseptable salter av forbindelsene. Forbindelsene er særlig anvendelige ved behandling eller forhindring av depresjon, angst, smerte, inflammasjon, migrene, emesis eller postherpetisk neuralgi.
NO20041431A 2001-09-10 2004-04-06 Tetrahydrofuranderivater og anvendelse av disse som terapeutiske midler NO20041431L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121874.2A GB0121874D0 (en) 2001-09-10 2001-09-10 Therapeutic agents
PCT/GB2002/004085 WO2003022839A1 (en) 2001-09-10 2002-09-06 Tetrahydropyran derivatives and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
NO20041431L true NO20041431L (no) 2004-06-01

Family

ID=9921835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20041431A NO20041431L (no) 2001-09-10 2004-04-06 Tetrahydrofuranderivater og anvendelse av disse som terapeutiske midler

Country Status (17)

Country Link
US (1) US7265110B2 (no)
EP (1) EP1427723B1 (no)
JP (1) JP2005506329A (no)
KR (1) KR20040045435A (no)
CN (1) CN1578778A (no)
AT (1) ATE328881T1 (no)
BR (1) BR0212454A (no)
CA (1) CA2459464A1 (no)
DE (1) DE60212153T2 (no)
ES (1) ES2263803T3 (no)
GB (1) GB0121874D0 (no)
IL (1) IL160785A0 (no)
MX (1) MXPA04002295A (no)
NO (1) NO20041431L (no)
PL (1) PL368208A1 (no)
RU (1) RU2004110950A (no)
WO (1) WO2003022839A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121874D0 (en) 2001-09-10 2001-10-31 Merck Sharp & Dohme Therapeutic agents
GB0217068D0 (en) * 2002-07-23 2002-08-28 Merck Sharp & Dohme Therapeutic agents
WO2004078750A1 (en) * 2003-03-07 2004-09-16 Merck Sharp & Dohme Limited Tetrahydropyran compounds as tachykinin antagonists
US11773127B2 (en) * 2017-11-08 2023-10-03 Washington University Compounds and methods for treating bacterial infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001574B1 (ru) * 1996-06-21 2001-06-25 Мерк Шарп Энд Домэ Лимитед Производные спиропиперидина и их использование в качестве терапевтических агентов
CO5150225A1 (es) 1999-03-19 2002-04-29 Merck Sharp & Dohme Derivados del tetrahidropirano y su uso como agentes terapeuticos
GB0020721D0 (en) * 2000-08-22 2000-10-11 Merck Sharp & Dohme Therapeutic agents
GB0121874D0 (en) 2001-09-10 2001-10-31 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
MXPA04002295A (es) 2004-06-18
IL160785A0 (en) 2004-08-31
EP1427723A1 (en) 2004-06-16
WO2003022839A1 (en) 2003-03-20
BR0212454A (pt) 2004-10-19
US7265110B2 (en) 2007-09-04
GB0121874D0 (en) 2001-10-31
KR20040045435A (ko) 2004-06-01
EP1427723B1 (en) 2006-06-07
CA2459464A1 (en) 2003-03-20
US20040254184A1 (en) 2004-12-16
CN1578778A (zh) 2005-02-09
ES2263803T3 (es) 2006-12-16
RU2004110950A (ru) 2005-04-10
ATE328881T1 (de) 2006-06-15
DE60212153D1 (de) 2006-07-20
DE60212153T2 (de) 2007-05-24
PL368208A1 (en) 2005-03-21
JP2005506329A (ja) 2005-03-03

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