NO2004008I2 - Bivalirudin - Google Patents

Bivalirudin

Info

Publication number
NO2004008I2
NO2004008I2 NO2004008C NO2004008C NO2004008I2 NO 2004008 I2 NO2004008 I2 NO 2004008I2 NO 2004008 C NO2004008 C NO 2004008C NO 2004008 C NO2004008 C NO 2004008C NO 2004008 I2 NO2004008 I2 NO 2004008I2
Authority
NO
Norway
Prior art keywords
molecules
thrombin
relates
moiety
csdm
Prior art date
Application number
NO2004008C
Other languages
English (en)
Other versions
NO2004008I1 (no
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27015128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2004008(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Health Research Inc filed Critical Health Research Inc
Publication of NO2004008I1 publication Critical patent/NO2004008I1/no
Publication of NO2004008I2 publication Critical patent/NO2004008I2/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
NO2004008C 1989-08-18 2004-11-29 Bivalirudin NO2004008I2 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39548289A 1989-08-18 1989-08-18
US07549388 US5196404B1 (en) 1989-08-18 1990-07-06 Inhibitors of thrombin
PCT/US1990/004642 WO1991002750A1 (en) 1989-08-18 1990-08-17 Novel inhibitors of thrombin

Publications (2)

Publication Number Publication Date
NO2004008I1 NO2004008I1 (no) 2004-12-27
NO2004008I2 true NO2004008I2 (no) 2008-01-28

Family

ID=27015128

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19920616A NO310294B1 (no) 1989-08-18 1992-02-17 Nye inhibitorer for trombin
NO2004008C NO2004008I2 (no) 1989-08-18 2004-11-29 Bivalirudin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19920616A NO310294B1 (no) 1989-08-18 1992-02-17 Nye inhibitorer for trombin

Country Status (18)

Country Link
US (3) US5196404B1 (no)
EP (1) EP0489070B1 (no)
JP (1) JPH0768141B2 (no)
KR (1) KR100199534B1 (no)
AT (1) ATE137246T1 (no)
AU (1) AU652125B2 (no)
CA (1) CA2065150C (no)
DE (2) DE122004000042I2 (no)
DK (1) DK0489070T3 (no)
ES (1) ES2086411T3 (no)
FI (1) FI102183B1 (no)
HK (1) HK1001562A1 (no)
HU (2) HUT60285A (no)
LU (1) LU91119I2 (no)
NL (1) NL300162I1 (no)
NO (2) NO310294B1 (no)
SG (1) SG79180A1 (no)
WO (1) WO1991002750A1 (no)

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US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
DE4005591A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
HUT63440A (en) 1990-06-15 1993-08-30 Ca Nat Research Council Proccess for producing thrombin inhibitors based on amino acid sequence of hirudine and pharmaceutical compositions comprising same
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
EP0570493B1 (en) * 1991-02-08 2000-01-05 Diatide, Inc. TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
AU659432B2 (en) * 1991-03-08 1995-05-18 Novartis Ag A method for the inhibition or prevention of tumor cell metastasis with hirudin
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
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US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
CA2136330C (en) * 1992-05-21 2002-03-19 Richard T. Dean Technetium-99m labeled peptides for thrombus imaging
WO1993025220A1 (en) * 1992-06-05 1993-12-23 Reid Thomas J Iii Test for quantitative thrombin time
US5476771A (en) * 1993-02-22 1995-12-19 The United States Of America As Represented By The Secretary Of The Army Test for quantitative thrombin time
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
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US6156540A (en) * 1993-12-22 2000-12-05 Human Genome Sciences, Inc. Thrombin inhibitor
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US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
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US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
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US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
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US6204384B1 (en) 1997-11-26 2001-03-20 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
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CA2340461A1 (en) * 2000-03-30 2001-09-30 University Of Manitoba Hirulog-like peptide and gene therapy
SI1278549T1 (sl) 2000-05-02 2009-04-30 Theravance Inc Sestavek, ki vsebuje ciklodekstrin in glikopeptidni antibiotik
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
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DE60232184D1 (de) * 2001-12-28 2009-06-10 Prysmian Spa Wasserbeständiges telekommunikations kabel
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
WO2004076484A1 (en) * 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
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CN101094867B (zh) * 2004-10-19 2011-08-24 隆萨股份公司 用于固相肽合成的方法
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CN101033249B (zh) * 2006-03-10 2011-05-11 周逸明 固相多肽合成比筏芦定的制备方法
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US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions
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PT2498731T (pt) 2009-11-11 2020-02-21 Chiesi Farm Spa Métodos de tratamento ou prevenção de uma trombose de endoprótese
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Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55500091A (no) * 1978-02-17 1980-02-14
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides
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NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
HUT63440A (en) * 1990-06-15 1993-08-30 Ca Nat Research Council Proccess for producing thrombin inhibitors based on amino acid sequence of hirudine and pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
ATE137246T1 (de) 1996-05-15
DE122004000042I1 (de) 2005-02-24
HU211158A9 (en) 1995-10-30
EP0489070B1 (en) 1996-04-24
US5691311A (en) 1997-11-25
EP0489070A1 (en) 1992-06-10
JPH04507253A (ja) 1992-12-17
KR100199534B1 (en) 1999-06-15
NO2004008I1 (no) 2004-12-27
NO920616L (no) 1992-04-13
US5433940A (en) 1995-07-18
DE122004000042I2 (de) 2008-01-24
FI102183B (fi) 1998-10-30
NO310294B1 (no) 2001-06-18
ES2086411T3 (es) 1996-07-01
CA2065150A1 (en) 1991-02-19
NL300162I2 (nl) 2005-01-03
KR920702372A (ko) 1992-09-03
DK0489070T3 (da) 1996-07-15
LU91119I2 (fr) 2004-12-29
HUT60285A (en) 1992-08-28
US5196404B1 (en) 1996-09-10
DE69026715T2 (de) 1996-10-17
US5196404A (en) 1993-03-23
DE69026715D1 (en) 1996-05-30
FI920672A0 (fi) 1992-02-17
FI102183B1 (fi) 1998-10-30
NL300162I1 (nl) 2005-01-03
SG79180A1 (en) 2001-03-20
HU9200473D0 (en) 1992-05-28
AU6284190A (en) 1991-04-03
WO1991002750A1 (en) 1991-03-07
AU652125B2 (en) 1994-08-18
JPH0768141B2 (ja) 1995-07-26
CA2065150C (en) 1999-12-14
NO920616D0 (no) 1992-02-17
HK1001562A1 (en) 1998-06-26

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