NO20035535L - Gammasekretaseinhibitorer - Google Patents
GammasekretaseinhibitorerInfo
- Publication number
- NO20035535L NO20035535L NO20035535A NO20035535A NO20035535L NO 20035535 L NO20035535 L NO 20035535L NO 20035535 A NO20035535 A NO 20035535A NO 20035535 A NO20035535 A NO 20035535A NO 20035535 L NO20035535 L NO 20035535L
- Authority
- NO
- Norway
- Prior art keywords
- val
- group
- leu
- alkyl
- ile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002121983 | 2002-04-24 | ||
PCT/JP2003/005017 WO2003091278A1 (fr) | 2002-04-24 | 2003-04-18 | Inhibiteurs de gamma secretase |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20035535D0 NO20035535D0 (no) | 2003-12-11 |
NO20035535L true NO20035535L (no) | 2004-02-19 |
NO329184B1 NO329184B1 (no) | 2010-09-06 |
Family
ID=29267426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20035535A NO329184B1 (no) | 2002-04-24 | 2003-12-11 | Gammasekretaseinhibitorer og anvendelse av disse i screening av inhibitorer av amyloidproteinproduksjon |
Country Status (11)
Country | Link |
---|---|
US (1) | US7585938B2 (no) |
EP (1) | EP1498421B1 (no) |
JP (1) | JP4404643B2 (no) |
KR (1) | KR101051249B1 (no) |
CN (1) | CN1319987C (no) |
AT (1) | ATE448242T1 (no) |
AU (1) | AU2003235283A1 (no) |
BR (1) | BR0304562A (no) |
DE (1) | DE60329995D1 (no) |
NO (1) | NO329184B1 (no) |
WO (1) | WO2003091278A1 (no) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
US8173423B2 (en) * | 2006-11-07 | 2012-05-08 | Vib Vzw | Diagnosis and treatment of T-cell acute lymphoblastic leukemia |
US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
US8501813B2 (en) | 2007-08-09 | 2013-08-06 | Kabushiki Kaisha Yakult Honsha | γ-secretase inhibitor |
EA022007B1 (ru) | 2009-09-11 | 2015-10-30 | Пробиодруг Аг | Гетероциклические производные в качестве ингибиторов глутаминилциклазы |
WO2012144972A2 (en) * | 2010-01-19 | 2012-10-26 | The General Hospital Corporation | Methods to inhibit neurodegeneration |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
CN102344485A (zh) * | 2010-08-05 | 2012-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 用于治疗阿尔茨海默病的肽类β分泌酶抑制剂及其用途 |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI870474A (fi) * | 1986-02-07 | 1987-08-08 | Ciba Geigy Ag | Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat. |
JP2003520266A (ja) | 2000-01-24 | 2003-07-02 | メルク シャープ エンド ドーム リミテッド | γ−セクレターゼ阻害薬 |
US6753410B2 (en) * | 2000-03-02 | 2004-06-22 | Merck & Co., Inc. | Investigational compounds |
WO2001085924A2 (en) * | 2000-05-11 | 2001-11-15 | Scios Inc. | MODULATION OF η-SECRETASE ACTIVITY |
US20030022251A1 (en) * | 2001-07-04 | 2003-01-30 | Boehringer Ingelheim Pharma Kg | Gamma-secretase in vitro screening assay |
-
2003
- 2003-04-18 US US10/511,269 patent/US7585938B2/en not_active Expired - Fee Related
- 2003-04-18 JP JP2003587836A patent/JP4404643B2/ja not_active Expired - Fee Related
- 2003-04-18 AT AT03720938T patent/ATE448242T1/de not_active IP Right Cessation
- 2003-04-18 DE DE60329995T patent/DE60329995D1/de not_active Expired - Lifetime
- 2003-04-18 KR KR1020047016996A patent/KR101051249B1/ko not_active IP Right Cessation
- 2003-04-18 EP EP03720938A patent/EP1498421B1/en not_active Expired - Lifetime
- 2003-04-18 CN CNB038118963A patent/CN1319987C/zh not_active Expired - Fee Related
- 2003-04-18 AU AU2003235283A patent/AU2003235283A1/en not_active Abandoned
- 2003-04-18 BR BR0304562-5A patent/BR0304562A/pt active Pending
- 2003-04-18 WO PCT/JP2003/005017 patent/WO2003091278A1/ja active Application Filing
- 2003-12-11 NO NO20035535A patent/NO329184B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60329995D1 (de) | 2009-12-24 |
EP1498421B1 (en) | 2009-11-11 |
ATE448242T1 (de) | 2009-11-15 |
EP1498421A1 (en) | 2005-01-19 |
KR20040106370A (ko) | 2004-12-17 |
NO329184B1 (no) | 2010-09-06 |
NO20035535D0 (no) | 2003-12-11 |
JP4404643B2 (ja) | 2010-01-27 |
CN1656115A (zh) | 2005-08-17 |
AU2003235283A1 (en) | 2003-11-10 |
US20060205666A1 (en) | 2006-09-14 |
BR0304562A (pt) | 2004-07-20 |
EP1498421A4 (en) | 2006-05-17 |
US7585938B2 (en) | 2009-09-08 |
CN1319987C (zh) | 2007-06-06 |
JPWO2003091278A1 (ja) | 2005-09-02 |
KR101051249B1 (ko) | 2011-07-21 |
WO2003091278A1 (fr) | 2003-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |