NO20031671L - Dioksolananaloger for forbedret intercellulaer avlevering - Google Patents
Dioksolananaloger for forbedret intercellulaer avleveringInfo
- Publication number
- NO20031671L NO20031671L NO20031671A NO20031671A NO20031671L NO 20031671 L NO20031671 L NO 20031671L NO 20031671 A NO20031671 A NO 20031671A NO 20031671 A NO20031671 A NO 20031671A NO 20031671 L NO20031671 L NO 20031671L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkenyl
- aryl
- case
- aromatic ring
- Prior art date
Links
- 150000002012 dioxanes Chemical class 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000006574 non-aromatic ring group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23988500P | 2000-10-13 | 2000-10-13 | |
| US28842401P | 2001-05-04 | 2001-05-04 | |
| PCT/CA2001/001464 WO2002030922A2 (fr) | 2000-10-13 | 2001-10-15 | Analogues de dioxolane pour administration intercellulaire amelioree |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20031671D0 NO20031671D0 (no) | 2003-04-11 |
| NO20031671L true NO20031671L (no) | 2003-06-13 |
Family
ID=26932965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031671A NO20031671L (no) | 2000-10-13 | 2003-04-11 | Dioksolananaloger for forbedret intercellulaer avlevering |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20030013660A1 (fr) |
| EP (1) | EP1324997A2 (fr) |
| JP (1) | JP2004510832A (fr) |
| KR (1) | KR20030096226A (fr) |
| CN (1) | CN100376570C (fr) |
| AU (2) | AU2002212015B2 (fr) |
| CA (1) | CA2425359A1 (fr) |
| HU (1) | HUP0301363A2 (fr) |
| MX (1) | MXPA03003278A (fr) |
| NO (1) | NO20031671L (fr) |
| NZ (1) | NZ537432A (fr) |
| PL (1) | PL361310A1 (fr) |
| WO (1) | WO2002030922A2 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4391087B2 (ja) | 2001-03-23 | 2009-12-24 | シャイアー カナダ インコーポレイテッド | 癌の処置のための薬学的組み合わせ |
| WO2003063771A2 (fr) | 2001-12-14 | 2003-08-07 | Pharmasset Ltd. | Nucleosides n4-acylcytosines pour le traitement d'infections virales |
| US20040192652A1 (en) * | 2002-12-06 | 2004-09-30 | Giles Francis J. | Pharmaceutical combinations and methods for the treatment of leukemia |
| GB0306907D0 (en) * | 2003-03-26 | 2003-04-30 | Angiogene Pharm Ltd | Boireductively-activated prodrugs |
| CA2554782C (fr) * | 2004-02-03 | 2013-08-13 | Emory University | Methodes de fabrication de nucleosides de 1,3-dioxolane |
| NO324263B1 (no) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
| WO2008030373A2 (fr) * | 2006-09-01 | 2008-03-13 | University Of Georgia Research Foundation, Inc. | Promédicaments l- oddc pour le cancer |
| EA022289B1 (ru) * | 2009-08-07 | 2015-12-30 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Производные n1-сульфонил-5-фторпиримидинона |
| MX337464B (es) * | 2011-06-06 | 2016-03-07 | Arbor Therapeutics Llc | Profarmacos lipofilicos labiles al acido de los agentes quimioterapeuticos contra el cancer. |
| WO2014105844A1 (fr) | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | Dérivés carboxylates de n-(substitué)-5-fluoro-4-imino-3-méthyle-2-oxo-3,4-dihydropyrimidine-1 (2h)- |
| CN104884062B (zh) | 2012-12-28 | 2018-11-06 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-甲酰胺衍生物 |
| AU2013370494B2 (en) | 2012-12-31 | 2017-08-17 | Adama Makhteshim Ltd. | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides |
| CN111362881A (zh) | 2013-12-31 | 2020-07-03 | 阿达玛马克西姆股份有限公司 | 一种化合物及其制备方法 |
| NZ722419A (en) | 2013-12-31 | 2018-01-26 | Adama Makhteshim Ltd | Synergistic fungicidal mixtures and compositions for fungal control |
| EA031106B1 (ru) * | 2014-08-25 | 2018-11-30 | Медивир Аб | Диоксолановые аналоги уридина для лечения рака |
| BR112017009876A2 (pt) * | 2014-11-14 | 2017-12-19 | Gemphire Therapeutics Inc | processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico |
| TWI687431B (zh) | 2015-06-22 | 2020-03-11 | 瑞典商米迪維艾克提伯拉公司 | 治療癌症之前藥 |
| PT3313449T (pt) | 2015-06-24 | 2020-10-30 | Nitto Denko Corp | Compostos ionizáveis e composições e suas utilizações |
| WO2017151044A1 (fr) * | 2016-03-02 | 2017-09-08 | Medivir Ab | Traitement d'association utilisant du sorafénib ou du régorafénib et un promédicament de la troxacitabine de type phosphoramidate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350753B1 (en) * | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
| US5270315A (en) * | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
| NZ228645A (en) * | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
| US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
| MXPA01009888A (es) * | 1999-03-29 | 2003-07-21 | Iaf Biochem Int | Metodos para tratar leucemia. |
| CA2399062C (fr) * | 2000-02-11 | 2010-01-12 | Shire Biochem Inc. | Synthese stereoselective d'analogues de nucleosides |
-
2001
- 2001-10-15 WO PCT/CA2001/001464 patent/WO2002030922A2/fr not_active Application Discontinuation
- 2001-10-15 US US09/976,249 patent/US20030013660A1/en not_active Abandoned
- 2001-10-15 CA CA002425359A patent/CA2425359A1/fr not_active Abandoned
- 2001-10-15 HU HU0301363A patent/HUP0301363A2/hu unknown
- 2001-10-15 KR KR10-2003-7005114A patent/KR20030096226A/ko not_active Application Discontinuation
- 2001-10-15 AU AU2002212015A patent/AU2002212015B2/en not_active Ceased
- 2001-10-15 MX MXPA03003278A patent/MXPA03003278A/es active IP Right Grant
- 2001-10-15 JP JP2002534308A patent/JP2004510832A/ja active Pending
- 2001-10-15 EP EP01980081A patent/EP1324997A2/fr not_active Withdrawn
- 2001-10-15 AU AU1201502A patent/AU1201502A/xx active Pending
- 2001-10-15 CN CNB018173659A patent/CN100376570C/zh not_active Expired - Lifetime
- 2001-10-15 NZ NZ537432A patent/NZ537432A/en unknown
- 2001-10-15 PL PL01361310A patent/PL361310A1/xx not_active Application Discontinuation
-
2003
- 2003-04-11 NO NO20031671A patent/NO20031671L/no unknown
-
2005
- 2005-06-10 US US11/149,193 patent/US20050256034A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002212015B2 (en) | 2007-01-25 |
| AU1201502A (en) | 2002-04-22 |
| HUP0301363A2 (hu) | 2005-12-28 |
| WO2002030922A3 (fr) | 2002-09-26 |
| CA2425359A1 (fr) | 2002-04-18 |
| JP2004510832A (ja) | 2004-04-08 |
| NO20031671D0 (no) | 2003-04-11 |
| MXPA03003278A (es) | 2005-07-01 |
| PL361310A1 (en) | 2004-10-04 |
| KR20030096226A (ko) | 2003-12-24 |
| WO2002030922A2 (fr) | 2002-04-18 |
| US20050256034A1 (en) | 2005-11-17 |
| EP1324997A2 (fr) | 2003-07-09 |
| CN100376570C (zh) | 2008-03-26 |
| CN1471526A (zh) | 2004-01-28 |
| NZ537432A (en) | 2005-05-27 |
| US20030013660A1 (en) | 2003-01-16 |
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