NO20030394L - N-[5-[[[5-alkyl-2-oksazolyl]metyl]tio]-2-tiazolyl]karboksamid-inhibitorer for cyklin-avhengige kinaser - Google Patents

N-[5-[[[5-alkyl-2-oksazolyl]metyl]tio]-2-tiazolyl]karboksamid-inhibitorer for cyklin-avhengige kinaser

Info

Publication number
NO20030394L
NO20030394L NO20030394A NO20030394A NO20030394L NO 20030394 L NO20030394 L NO 20030394L NO 20030394 A NO20030394 A NO 20030394A NO 20030394 A NO20030394 A NO 20030394A NO 20030394 L NO20030394 L NO 20030394L
Authority
NO
Norway
Prior art keywords
cyclin
oxazolyl
thiazolyl
thio
alkyl
Prior art date
Application number
NO20030394A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030394D0 (no
Inventor
Raj Narain Misra
Hai-Yun Xiao
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/727,957 external-priority patent/US6515004B1/en
Priority claimed from US09/746,060 external-priority patent/US6414156B2/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20030394D0 publication Critical patent/NO20030394D0/no
Publication of NO20030394L publication Critical patent/NO20030394L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20030394A 2000-07-26 2003-01-24 N-[5-[[[5-alkyl-2-oksazolyl]metyl]tio]-2-tiazolyl]karboksamid-inhibitorer for cyklin-avhengige kinaser NO20030394L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61662700A 2000-07-26 2000-07-26
US09/727,957 US6515004B1 (en) 1999-12-15 2000-12-01 N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US09/746,060 US6414156B2 (en) 1998-10-21 2000-12-22 Process for preparing azacycloalkanoylaminothiazoles
PCT/US2001/015081 WO2002010162A1 (en) 2000-07-26 2001-05-09 N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases

Publications (2)

Publication Number Publication Date
NO20030394D0 NO20030394D0 (no) 2003-01-24
NO20030394L true NO20030394L (no) 2003-03-03

Family

ID=27417184

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030394A NO20030394L (no) 2000-07-26 2003-01-24 N-[5-[[[5-alkyl-2-oksazolyl]metyl]tio]-2-tiazolyl]karboksamid-inhibitorer for cyklin-avhengige kinaser

Country Status (26)

Country Link
EP (1) EP1303513A1 (enrdf_load_stackoverflow)
JP (1) JP2004509857A (enrdf_load_stackoverflow)
KR (1) KR20030016429A (enrdf_load_stackoverflow)
CN (1) CN100457753C (enrdf_load_stackoverflow)
AR (1) AR030563A1 (enrdf_load_stackoverflow)
AU (1) AU2001259704A1 (enrdf_load_stackoverflow)
BG (1) BG65132B1 (enrdf_load_stackoverflow)
BR (1) BR0112674A (enrdf_load_stackoverflow)
CA (1) CA2417254A1 (enrdf_load_stackoverflow)
CZ (1) CZ2003237A3 (enrdf_load_stackoverflow)
EE (1) EE200300041A (enrdf_load_stackoverflow)
EG (1) EG24409A (enrdf_load_stackoverflow)
GE (1) GEP20043367B (enrdf_load_stackoverflow)
HR (1) HRP20030116A2 (enrdf_load_stackoverflow)
HU (1) HUP0303698A2 (enrdf_load_stackoverflow)
IL (2) IL153591A0 (enrdf_load_stackoverflow)
LV (1) LV13037B (enrdf_load_stackoverflow)
MX (1) MXPA03000774A (enrdf_load_stackoverflow)
MY (1) MY129635A (enrdf_load_stackoverflow)
NO (1) NO20030394L (enrdf_load_stackoverflow)
PL (1) PL365170A1 (enrdf_load_stackoverflow)
SI (1) SI21099A (enrdf_load_stackoverflow)
SK (1) SK18392002A3 (enrdf_load_stackoverflow)
TW (1) TWI302533B (enrdf_load_stackoverflow)
WO (1) WO2002010162A1 (enrdf_load_stackoverflow)
YU (1) YU4903A (enrdf_load_stackoverflow)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414156B2 (en) 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
AR038703A1 (es) 2002-02-28 2005-01-26 Novartis Ag Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
EP2311818B1 (en) * 2002-02-28 2013-01-16 Novartis AG Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
EP1545533A1 (en) 2002-09-04 2005-06-29 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PT1537116E (pt) 2002-09-04 2010-09-03 Schering Corp Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
TW200412967A (en) 2002-09-23 2004-08-01 Schering Corp Novel imidazopyrazines as cyclin dependent kinase inhibitors
ATE377600T1 (de) 2002-09-23 2007-11-15 Schering Corp Imidazopyrazine als cdk-inhibitoren
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
EP1555264A1 (en) * 2004-01-15 2005-07-20 Sireen AG Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.
DE102005008310A1 (de) * 2005-02-17 2006-08-24 Schering Ag Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle
US7446195B2 (en) 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
ES2349476T3 (es) 2005-09-09 2011-01-03 Schering Corporation Nuevos derivados de 4-ciano, 4-amino y 4-aminometilo de compuestos de pirazolo[1,5-a]piridinas, pirazolo[1,5-c]pirimidinas y 2h-indazol y derivados de 5-ciano, 5-amino y 5-aminometilo de compuestos de imidazo[1,2-a]piridinas e imidazo[1,5-a]pirazinas, como inhibidores de cinasa dependiente de ciclina.
TW200745123A (en) 2005-10-06 2007-12-16 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
EP2044066A2 (en) * 2006-06-06 2009-04-08 Bristol-Myers Squibb Company Crystalline forms of n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl] thio]-2-thiazolyl]-4-piperidinecarboxamide
US20090175852A1 (en) 2006-06-06 2009-07-09 Schering Corporation Imidazopyrazines as protein kinase inhibitors
PE20080928A1 (es) 2006-10-31 2008-08-15 Schering Corp Derivados de anilinopiperazina como inhibidores de proteina quinasa
KR20090075873A (ko) 2006-10-31 2009-07-09 쉐링 코포레이션 아닐리노피페라진 유도체 및 이의 사용방법
MX2009012054A (es) 2007-05-08 2009-11-19 Schering Corp Metodos de tratamiento que usan formulaciones intravenosas que comprenden temozolomida.
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
WO2010075542A1 (en) 2008-12-23 2010-07-01 Curis, Inc. Cdk inhibitors
US8669259B2 (en) 2009-08-26 2014-03-11 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
ES2685709T3 (es) 2012-03-30 2018-10-10 Merck Sharp & Dohme Corp. Biomarcador predictivo mediado por un inhibidor de CDK útil para la terapia contra el cáncer
EP3078671A4 (en) * 2013-12-04 2017-05-31 Hangzhou Minsheng Institutes for Pharma Research Co., Ltd. Gemcitabine derivative, composition containing the derivative and pharmaceutical use of the derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6262096B1 (en) * 1997-11-12 2001-07-17 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
DE69923681T2 (de) * 1998-06-18 2006-01-12 Bristol-Myers Squibb Co. Kohlenstoff substituierte aminothiazole als inhibitoren von cyclin-abhängigen kinasen
US6414156B2 (en) * 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
MY125768A (en) * 1999-12-15 2006-08-30 Bristol Myers Squibb Co N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

Also Published As

Publication number Publication date
CZ2003237A3 (cs) 2003-06-18
EE200300041A (et) 2005-04-15
EP1303513A1 (en) 2003-04-23
HRP20030116A2 (en) 2005-02-28
AR030563A1 (es) 2003-08-27
GEP20043367B (en) 2004-06-10
PL365170A1 (en) 2004-12-27
TWI302533B (en) 2008-11-01
CA2417254A1 (en) 2002-02-07
EG24409A (en) 2009-05-20
JP2004509857A (ja) 2004-04-02
IL153591A0 (en) 2003-07-06
SI21099A (sl) 2003-06-30
MXPA03000774A (es) 2003-09-10
MY129635A (en) 2007-04-30
YU4903A (sh) 2006-03-03
KR20030016429A (ko) 2003-02-26
NO20030394D0 (no) 2003-01-24
BR0112674A (pt) 2003-12-30
CN100457753C (zh) 2009-02-04
CN1444584A (zh) 2003-09-24
SK18392002A3 (sk) 2003-09-11
BG65132B1 (bg) 2007-03-30
LV13037B (en) 2003-11-20
AU2001259704A1 (en) 2002-02-13
IL153591A (en) 2009-07-20
BG107468A (en) 2004-01-30
WO2002010162A1 (en) 2002-02-07
HUP0303698A2 (hu) 2004-04-28

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