NO20025004L - Fremgangsmåte for fremstilling av 2,5-diketopiperaziner, 2,5- diketopiperaziner, dipeptider samt anvendelse derav - Google Patents

Fremgangsmåte for fremstilling av 2,5-diketopiperaziner, 2,5- diketopiperaziner, dipeptider samt anvendelse derav

Info

Publication number
NO20025004L
NO20025004L NO20025004A NO20025004A NO20025004L NO 20025004 L NO20025004 L NO 20025004L NO 20025004 A NO20025004 A NO 20025004A NO 20025004 A NO20025004 A NO 20025004A NO 20025004 L NO20025004 L NO 20025004L
Authority
NO
Norway
Prior art keywords
diketopiperazines
dipeptides
preparation
Prior art date
Application number
NO20025004A
Other languages
English (en)
Other versions
NO323617B1 (no
NO20025004D0 (no
Inventor
Karlheinz Drauz
Guenter Knaup
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa filed Critical Degussa
Publication of NO20025004D0 publication Critical patent/NO20025004D0/no
Publication of NO20025004L publication Critical patent/NO20025004L/no
Publication of NO323617B1 publication Critical patent/NO323617B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20025004A 2000-04-20 2002-10-17 Fremgangsmate for fremstilling av 2,5-diketopiperaziner, 2,5-diketopiperaziner, dipeptider samt anvendelse derav NO323617B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019879A DE10019879A1 (de) 2000-04-20 2000-04-20 Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
PCT/EP2001/003322 WO2001081321A1 (de) 2000-04-20 2001-03-23 Verfahren zur herstellung von 2,5-diketopiperazinen, 2,5-diketopiperazine, dipeptide und deren verwendung

Publications (3)

Publication Number Publication Date
NO20025004D0 NO20025004D0 (no) 2002-10-17
NO20025004L true NO20025004L (no) 2002-12-19
NO323617B1 NO323617B1 (no) 2007-06-18

Family

ID=7639634

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025004A NO323617B1 (no) 2000-04-20 2002-10-17 Fremgangsmate for fremstilling av 2,5-diketopiperaziner, 2,5-diketopiperaziner, dipeptider samt anvendelse derav

Country Status (6)

Country Link
US (1) US20040024180A1 (no)
EP (1) EP1274693A1 (no)
JP (1) JP2003531197A (no)
DE (1) DE10019879A1 (no)
NO (1) NO323617B1 (no)
WO (1) WO2001081321A1 (no)

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AU2003281978A1 (en) * 2002-11-22 2004-06-18 Boehringer Ingelheim International Gmbh 2,5-diketopiperazines for the treatment of obesity
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JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
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EP1928423B1 (en) 2005-09-14 2015-12-09 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US8217047B2 (en) * 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101558026B1 (ko) 2008-06-13 2015-10-06 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
MX346331B (es) * 2011-02-10 2017-03-15 Mannkind Corp Formación de bis-3, 6-(4-aminoalquil) - 2, 5-dicetopiperazina con n protegido.
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
PL2766029T3 (pl) 2011-10-10 2020-08-24 Ampio Pharmaceuticals, Inc. Leczenie choroby zwyrodnieniowej stawów
KR20140075772A (ko) 2011-10-10 2014-06-19 앰피오 파마슈티컬스 인코퍼레이티드 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
US10881710B2 (en) 2011-10-28 2021-01-05 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
JP6241682B2 (ja) 2012-04-27 2017-12-06 マンカインド・コーポレイシヨン 活性化したエチルフマレートの合成のための方法および中間体としてのその使用
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
US10364262B2 (en) 2012-07-17 2019-07-30 Monsanto Technology Llc Method for the synthesis of N-phosphonomethyliminodiacetic acid
US10280189B2 (en) 2012-07-17 2019-05-07 Monsanto Technology Llc Method for the synthesis of aminoalkylenephosphonic acid
CN104812765B (zh) 2012-07-17 2017-06-06 斯特雷特马克控股股份公司 用于合成α‑氨基亚烷基膦酸的方法
BR112015000995B1 (pt) 2012-07-17 2020-04-28 Monsanto Technology Llc método para a síntese de n-(fosfonometil)glicina ou um de seus derivados selecionados a partir do grupo que consiste em seus sais, seus ésteres de fosfonato e seus sais de éster de fosfonato
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
KR20150132508A (ko) 2013-03-15 2015-11-25 앰피오 파마슈티컬스 인코퍼레이티드 줄기세포의 가동화, 회귀, 증식 및 분화를 위한 조성물 및 이의 사용 방법
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
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FR2629823B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Chimie Procede de purification de peptides
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
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DE69121502T2 (de) * 1990-03-15 1997-01-16 Nutrasweet Co Prozess zur darstellung von aspartam aus einem diketopiperazin sowie neue zwischenprodukte und derivate dafür
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US5418218A (en) * 1992-07-10 1995-05-23 The University Of Maryland At Baltimore Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent
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JP2000507970A (ja) * 1997-01-10 2000-06-27 メルク エンド カンパニー インコーポレーテッド キラルメディエータの効率的な合成

Also Published As

Publication number Publication date
DE10019879A1 (de) 2001-10-25
NO323617B1 (no) 2007-06-18
WO2001081321A1 (de) 2001-11-01
JP2003531197A (ja) 2003-10-21
EP1274693A1 (de) 2003-01-15
NO20025004D0 (no) 2002-10-17
US20040024180A1 (en) 2004-02-05

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