NO20021831L - Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra - Google Patents

Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra

Info

Publication number
NO20021831L
NO20021831L NO20021831A NO20021831A NO20021831L NO 20021831 L NO20021831 L NO 20021831L NO 20021831 A NO20021831 A NO 20021831A NO 20021831 A NO20021831 A NO 20021831A NO 20021831 L NO20021831 L NO 20021831L
Authority
NO
Norway
Prior art keywords
compound
formula
derivatives
casodex
bicalutamide
Prior art date
Application number
NO20021831A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021831D0 (no
Inventor
Nnochiri N Ekwuribe
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of NO20021831D0 publication Critical patent/NO20021831D0/no
Publication of NO20021831L publication Critical patent/NO20021831L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20021831A 1999-10-19 2002-04-18 Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra NO20021831L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16041299P 1999-10-19 1999-10-19
PCT/US2000/041233 WO2001028990A2 (en) 1999-10-19 2000-10-18 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof

Publications (2)

Publication Number Publication Date
NO20021831D0 NO20021831D0 (no) 2002-04-18
NO20021831L true NO20021831L (no) 2002-06-19

Family

ID=22576803

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021831A NO20021831L (no) 1999-10-19 2002-04-18 Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra

Country Status (18)

Country Link
US (2) US6583306B1 (da)
EP (1) EP1222165A2 (da)
JP (1) JP5112583B2 (da)
KR (1) KR20020091047A (da)
CN (1) CN1409702A (da)
AU (1) AU1968601A (da)
BR (1) BR0014889A (da)
CA (1) CA2387570A1 (da)
CZ (1) CZ20021340A3 (da)
HK (1) HK1048298A1 (da)
HU (1) HUP0203785A2 (da)
IL (2) IL149056A0 (da)
MX (1) MXPA02003884A (da)
NO (1) NO20021831L (da)
NZ (1) NZ518392A (da)
PL (1) PL354620A1 (da)
WO (1) WO2001028990A2 (da)
ZA (1) ZA200202947B (da)

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US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7547728B2 (en) 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
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US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
EP1462442B1 (en) 2001-12-13 2009-08-26 Sumitomo Chemical Company, Limited Crystals of bicalutamide and process for their production
EA200901492A1 (ru) 2002-02-07 2010-08-30 Юниверсити Оф Теннесси Рисерч Фаундейшн Лечение доброкачественной гиперплазии простаты селективным модулятором рецептора андрогенов (sarm)
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
US7344700B2 (en) 2002-02-28 2008-03-18 University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
DE10222104A1 (de) 2002-05-17 2003-12-04 Helm Ag Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
CA2489182A1 (en) 2002-06-17 2003-12-24 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
EP1402924B1 (de) * 2002-09-04 2008-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung eines Mittel zur Therapie der Herzhypertrophie
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
CN1726034A (zh) 2002-10-15 2006-01-25 田纳西大学研究基金会 亚甲基桥连的选择性雄激素受体调节剂及其应用方法
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
MXPA06000119A (es) 2003-12-16 2006-03-21 Gtx Inc Profarmacos de moduladores receptores de androgenos selectivos y metodos de uso de los mismos.
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
BRPI0714526A2 (pt) 2006-08-24 2013-04-30 Univ Tennessee Res Foundation acilanilidas substituÍdas e seus mÉtodos de uso
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
ITBO20090236A1 (it) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche Procedimento per la sintesi di composti per il trattamento del tumore alla prostata
WO2010116342A2 (en) * 2009-04-10 2010-10-14 Consiglio Nazionale Delle Ricerche Non-steroidal compounds for androgen receptor modulation
US8450374B2 (en) * 2009-06-29 2013-05-28 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
KR102122941B1 (ko) 2012-07-13 2020-06-15 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법

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Also Published As

Publication number Publication date
CA2387570A1 (en) 2001-04-26
CN1409702A (zh) 2003-04-09
BR0014889A (pt) 2002-12-31
NO20021831D0 (no) 2002-04-18
KR20020091047A (ko) 2002-12-05
CZ20021340A3 (cs) 2002-08-14
US7022869B2 (en) 2006-04-04
WO2001028990A3 (en) 2001-09-07
JP5112583B2 (ja) 2013-01-09
IL149056A (en) 2011-05-31
ZA200202947B (en) 2003-09-23
WO2001028990A2 (en) 2001-04-26
US20040030130A1 (en) 2004-02-12
JP2003512351A (ja) 2003-04-02
HK1048298A1 (zh) 2003-03-28
HUP0203785A2 (hu) 2003-04-28
IL149056A0 (en) 2002-11-10
NZ518392A (en) 2004-02-27
PL354620A1 (en) 2004-02-09
AU1968601A (en) 2001-04-30
US6583306B1 (en) 2003-06-24
EP1222165A2 (en) 2002-07-17
MXPA02003884A (es) 2004-09-06

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