NO20021783L - Alkylamino-substituerte bicykliske nitrogen-heterocykler som inhibitorer for P38-protein-kinase - Google Patents
Alkylamino-substituerte bicykliske nitrogen-heterocykler som inhibitorer for P38-protein-kinaseInfo
- Publication number
- NO20021783L NO20021783L NO20021783A NO20021783A NO20021783L NO 20021783 L NO20021783 L NO 20021783L NO 20021783 A NO20021783 A NO 20021783A NO 20021783 A NO20021783 A NO 20021783A NO 20021783 L NO20021783 L NO 20021783L
- Authority
- NO
- Norway
- Prior art keywords
- alkylamino
- inhibitors
- protein kinase
- substituted bicyclic
- nitrogen heterocycles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16080499P | 1999-10-21 | 1999-10-21 | |
US21371800P | 2000-06-22 | 2000-06-22 | |
PCT/EP2000/010077 WO2001029041A1 (en) | 1999-10-21 | 2000-10-13 | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20021783D0 NO20021783D0 (no) | 2002-04-16 |
NO20021783L true NO20021783L (no) | 2002-04-16 |
Family
ID=26857242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20021783A NO20021783L (no) | 1999-10-21 | 2002-04-16 | Alkylamino-substituerte bicykliske nitrogen-heterocykler som inhibitorer for P38-protein-kinase |
Country Status (25)
Country | Link |
---|---|
US (1) | US6642241B1 (no) |
EP (1) | EP1226144B1 (no) |
KR (1) | KR100537241B1 (no) |
CN (1) | CN1156477C (no) |
AR (1) | AR026187A1 (no) |
AT (1) | ATE349447T1 (no) |
AU (1) | AU776695B2 (no) |
BR (1) | BR0014973A (no) |
CA (1) | CA2388140C (no) |
CO (1) | CO5251408A1 (no) |
CZ (1) | CZ20021743A3 (no) |
DE (1) | DE60032623T2 (no) |
ES (1) | ES2277858T3 (no) |
HK (1) | HK1051040A1 (no) |
HR (1) | HRP20020327A2 (no) |
HU (1) | HUP0203477A3 (no) |
IL (1) | IL149230A0 (no) |
MA (1) | MA26836A1 (no) |
MX (1) | MXPA02003841A (no) |
NO (1) | NO20021783L (no) |
PE (1) | PE20010760A1 (no) |
PL (1) | PL357494A1 (no) |
TR (1) | TR200201058T2 (no) |
WO (1) | WO2001029041A1 (no) |
YU (1) | YU29202A (no) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040044012A1 (en) * | 1998-05-26 | 2004-03-04 | Dobrusin Ellen Myra | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
ES2310039T3 (es) | 1998-05-26 | 2008-12-16 | Warner-Lambert Company Llc | Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular. |
US7629350B2 (en) * | 2002-04-19 | 2009-12-08 | Smithkline Beecham Corporation | Compounds |
JP2005538066A (ja) | 2002-07-09 | 2005-12-15 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な抗コリン作用薬及びp38キナーゼ阻害剤を用いた新規な医薬組成物 |
PA8577501A1 (es) | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
KR100793688B1 (ko) * | 2002-08-06 | 2008-01-10 | 에프. 호프만-라 로슈 아게 | P-38 미토겐 활성 단백질 키나제 억제제로서6-알콕시-피리도-피리미딘 |
EP1539755B1 (en) | 2002-08-06 | 2007-09-26 | F. Hoffmann-La Roche Ag | 6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors |
US7084270B2 (en) * | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
US7129351B2 (en) | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
RU2350617C2 (ru) * | 2003-04-10 | 2009-03-27 | Ф.Хоффманн-Ля Рош Аг | Пиримидиновые соединения, обладающие свойствами селективного ингибирования активности кдр и фрфр |
EP1743945A4 (en) * | 2004-04-27 | 2009-06-10 | Takeda Pharmaceutical | SCREENING METHOD |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
DE602005013248D1 (de) | 2004-08-31 | 2009-04-23 | Hoffmann La Roche | Amidderivate von 3-phenyldihydropyrimidoä4,5-düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel |
BRPI0514750A (pt) | 2004-08-31 | 2008-06-24 | Hoffmann La Roche | derivados amida de 7-amino-3-fenil-diidropirimido[4, 5-d]pirimidinonas, sua fabricação e uso como inibidores de proteìna cinase |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
CA2636981A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
EP2108641A1 (en) * | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
LT3176170T (lt) | 2012-06-13 | 2019-04-25 | Incyte Holdings Corporation | Pakeisti tricikliniai junginiai, kaip fgfr inhibitoriai |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
US9663524B2 (en) | 2013-03-15 | 2017-05-30 | Celgene Car Llc | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors |
TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CN107438607B (zh) | 2015-02-20 | 2021-02-05 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
PL3691620T3 (pl) | 2017-10-05 | 2022-11-21 | Fulcrum Therapeutics, Inc. | Inhibitory kinazy p38 zmniejszają poziom ekspresji genu dux4 i dalszych genów do leczenia fshd |
WO2019213506A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
PE20210920A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Formas solidas de un inhibidor de fgfr y procesos para prepararlas |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
KR20220100879A (ko) | 2019-10-14 | 2022-07-18 | 인사이트 코포레이션 | Fgfr 저해제로서의 이환식 헤테로사이클 |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
GB201915828D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8814352D0 (en) | 1988-06-16 | 1988-07-20 | Smith Kline French Lab | Chemical compounds |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
ES2221213T3 (es) * | 1997-10-20 | 2004-12-16 | F. Hoffmann-La Roche Ag | Inhibidores de kinasa biciclicos. |
ES2310039T3 (es) * | 1998-05-26 | 2008-12-16 | Warner-Lambert Company Llc | Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular. |
PL347432A1 (en) | 1998-10-23 | 2002-04-08 | Hoffmann La Roche | Bicyclic nitrogen heterocycles |
-
2000
- 2000-10-13 DE DE60032623T patent/DE60032623T2/de not_active Expired - Fee Related
- 2000-10-13 PL PL00357494A patent/PL357494A1/xx not_active Application Discontinuation
- 2000-10-13 BR BR0014973-0A patent/BR0014973A/pt not_active IP Right Cessation
- 2000-10-13 CA CA002388140A patent/CA2388140C/en not_active Expired - Fee Related
- 2000-10-13 HU HU0203477A patent/HUP0203477A3/hu unknown
- 2000-10-13 AU AU11375/01A patent/AU776695B2/en not_active Ceased
- 2000-10-13 EP EP00972755A patent/EP1226144B1/en not_active Expired - Lifetime
- 2000-10-13 CZ CZ20021743A patent/CZ20021743A3/cs unknown
- 2000-10-13 IL IL14923000A patent/IL149230A0/xx unknown
- 2000-10-13 ES ES00972755T patent/ES2277858T3/es not_active Expired - Lifetime
- 2000-10-13 MX MXPA02003841A patent/MXPA02003841A/es active IP Right Grant
- 2000-10-13 TR TR2002/01058T patent/TR200201058T2/xx unknown
- 2000-10-13 KR KR10-2002-7005056A patent/KR100537241B1/ko not_active IP Right Cessation
- 2000-10-13 AT AT00972755T patent/ATE349447T1/de not_active IP Right Cessation
- 2000-10-13 YU YU29202A patent/YU29202A/sh unknown
- 2000-10-13 CN CNB00814544XA patent/CN1156477C/zh not_active Expired - Fee Related
- 2000-10-13 WO PCT/EP2000/010077 patent/WO2001029041A1/en not_active Application Discontinuation
- 2000-10-17 PE PE2000001106A patent/PE20010760A1/es not_active Application Discontinuation
- 2000-10-19 CO CO00079670A patent/CO5251408A1/es not_active Application Discontinuation
- 2000-10-20 US US09/693,364 patent/US6642241B1/en not_active Expired - Fee Related
- 2000-10-20 AR ARP000105524A patent/AR026187A1/es not_active Application Discontinuation
-
2002
- 2002-04-12 HR HR20020327A patent/HRP20020327A2/hr not_active Application Discontinuation
- 2002-04-16 NO NO20021783A patent/NO20021783L/no not_active Application Discontinuation
- 2002-04-19 MA MA26611A patent/MA26836A1/fr unknown
-
2003
- 2003-05-06 HK HK03103209A patent/HK1051040A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1226144B1 (en) | 2006-12-27 |
AU776695B2 (en) | 2004-09-16 |
NO20021783D0 (no) | 2002-04-16 |
PE20010760A1 (es) | 2001-07-21 |
CN1156477C (zh) | 2004-07-07 |
AU1137501A (en) | 2001-04-30 |
KR100537241B1 (ko) | 2005-12-19 |
PL357494A1 (en) | 2004-07-26 |
BR0014973A (pt) | 2002-07-16 |
HK1051040A1 (en) | 2003-07-18 |
CZ20021743A3 (cs) | 2002-08-14 |
CA2388140C (en) | 2008-09-02 |
TR200201058T2 (tr) | 2002-07-22 |
CO5251408A1 (es) | 2003-02-28 |
WO2001029041A1 (en) | 2001-04-26 |
YU29202A (sh) | 2004-12-31 |
HUP0203477A2 (hu) | 2003-01-28 |
ATE349447T1 (de) | 2007-01-15 |
DE60032623T2 (de) | 2007-10-11 |
JP2003512377A (ja) | 2003-04-02 |
CN1382142A (zh) | 2002-11-27 |
ES2277858T3 (es) | 2007-08-01 |
KR20020039375A (ko) | 2002-05-25 |
JP4028236B2 (ja) | 2007-12-26 |
US6642241B1 (en) | 2003-11-04 |
AR026187A1 (es) | 2003-01-29 |
DE60032623D1 (de) | 2007-02-08 |
HRP20020327A2 (en) | 2004-02-29 |
CA2388140A1 (en) | 2001-04-26 |
IL149230A0 (en) | 2002-11-10 |
MA26836A1 (fr) | 2004-12-20 |
MXPA02003841A (es) | 2002-09-30 |
HUP0203477A3 (en) | 2004-12-28 |
EP1226144A1 (en) | 2002-07-31 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |