NO20015992L - Fremgangsmåte for inhibering av amyloidprotein-aggregering og billeddannelse av amyloidavleiring ved bruk av isoindolin-derivater - Google Patents

Fremgangsmåte for inhibering av amyloidprotein-aggregering og billeddannelse av amyloidavleiring ved bruk av isoindolin-derivater

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Publication number
NO20015992L
NO20015992L NO20015992A NO20015992A NO20015992L NO 20015992 L NO20015992 L NO 20015992L NO 20015992 A NO20015992 A NO 20015992A NO 20015992 A NO20015992 A NO 20015992A NO 20015992 L NO20015992 L NO 20015992L
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Norway
Prior art keywords
amyloid
depletion
imaging
protein aggregation
inhibiting
Prior art date
Application number
NO20015992A
Other languages
English (en)
Norwegian (no)
Other versions
NO20015992D0 (no
Inventor
Corinne Elizab Augelli-Szafran
Yingjie Lai
Annette Theresa Sakkab
Lary Craswell Walker
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO20015992D0 publication Critical patent/NO20015992D0/no
Publication of NO20015992L publication Critical patent/NO20015992L/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO20015992A 1999-06-10 2001-12-07 Fremgangsmåte for inhibering av amyloidprotein-aggregering og billeddannelse av amyloidavleiring ved bruk av isoindolin-derivater NO20015992L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13854399P 1999-06-10 1999-06-10
PCT/US2000/015073 WO2000076969A1 (en) 1999-06-10 2000-05-31 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives

Publications (2)

Publication Number Publication Date
NO20015992D0 NO20015992D0 (no) 2001-12-07
NO20015992L true NO20015992L (no) 2002-02-06

Family

ID=22482508

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20015992A NO20015992L (no) 1999-06-10 2001-12-07 Fremgangsmåte for inhibering av amyloidprotein-aggregering og billeddannelse av amyloidavleiring ved bruk av isoindolin-derivater

Country Status (38)

Country Link
EP (1) EP1192131B1 (zh)
JP (1) JP2003502313A (zh)
KR (1) KR20020012266A (zh)
CN (1) CN1156445C (zh)
AP (1) AP1398A (zh)
AT (1) ATE272623T1 (zh)
AU (1) AU777747B2 (zh)
BG (1) BG106291A (zh)
BR (1) BR0011446A (zh)
CA (1) CA2373394A1 (zh)
CR (1) CR6530A (zh)
CZ (1) CZ20014366A3 (zh)
DE (1) DE60012742T2 (zh)
DK (1) DK1192131T3 (zh)
DZ (1) DZ3262A1 (zh)
EA (1) EA004405B1 (zh)
EE (1) EE200100666A (zh)
ES (1) ES2223531T3 (zh)
GE (1) GEP20043407B (zh)
HK (1) HK1046283B (zh)
HR (1) HRP20020027A2 (zh)
HU (1) HUP0201586A2 (zh)
IL (1) IL146455A0 (zh)
IS (1) IS6162A (zh)
MA (1) MA26807A1 (zh)
MX (1) MXPA01011112A (zh)
NO (1) NO20015992L (zh)
NZ (1) NZ515619A (zh)
OA (1) OA11958A (zh)
PL (1) PL352294A1 (zh)
PT (1) PT1192131E (zh)
SI (1) SI1192131T1 (zh)
SK (1) SK17622001A3 (zh)
TR (1) TR200200257T2 (zh)
UA (1) UA64842C2 (zh)
WO (1) WO2000076969A1 (zh)
YU (1) YU86801A (zh)
ZA (1) ZA200109164B (zh)

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CA2357450A1 (en) * 2000-09-29 2002-03-29 Warner-Lambert Company Phenoxazine analogs useful as amyloid aggregation inhibitors and treatment of alzheimer's disease and disorders related to amyloidosis
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AR061623A1 (es) 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico
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AU2008215948A1 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of AD and related conditions
PT2307381T (pt) * 2008-06-09 2021-03-15 Univ Muenchen Ludwig Maximilians Novas drogas para inibir a agregação de proteínas envolvidas em doenças relacionadas com a agregação de proteínas e/ou doenças neurodegenerativas
KR20110113197A (ko) 2009-02-06 2011-10-14 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물
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BR112012017442A2 (pt) 2010-01-15 2016-04-19 Janssen Pharmaceuticals Inc derivados de triazol bicíclicos substituídos como moduladores de gamma secretase
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BR112014028395B1 (pt) 2012-05-16 2022-02-01 Janssen Pharmaceuticals, Inc. Derivados 3,4-di-hidro-2h-pirido[1,2-a]pirazina-1,6-diona substituídos úteis para o tratamento de (inter alia) doença de alzheimer e composição farmacêutica que os compreende
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Also Published As

Publication number Publication date
AU5312000A (en) 2001-01-02
PL352294A1 (en) 2003-08-11
EE200100666A (et) 2003-02-17
BR0011446A (pt) 2002-03-19
EA200101133A1 (ru) 2002-06-27
JP2003502313A (ja) 2003-01-21
HUP0201586A2 (en) 2002-08-28
GEP20043407B (en) 2004-05-10
MXPA01011112A (es) 2002-06-04
OA11958A (en) 2006-04-13
BG106291A (bg) 2002-05-31
AP2002002389A0 (en) 2002-03-31
HRP20020027A2 (en) 2005-02-28
YU86801A (sh) 2004-07-15
TR200200257T2 (tr) 2002-06-21
CN1156445C (zh) 2004-07-07
AU777747B2 (en) 2004-10-28
PT1192131E (pt) 2004-11-30
ZA200109164B (en) 2003-02-06
SI1192131T1 (en) 2004-12-31
HK1046283B (zh) 2005-01-07
KR20020012266A (ko) 2002-02-15
DK1192131T3 (da) 2004-12-13
DE60012742D1 (de) 2004-09-09
MA26807A1 (fr) 2004-12-20
WO2000076969A1 (en) 2000-12-21
IL146455A0 (en) 2002-07-25
HK1046283A1 (en) 2003-01-03
CN1355790A (zh) 2002-06-26
AP1398A (en) 2005-04-21
DZ3262A1 (fr) 2000-12-12
DE60012742T2 (de) 2005-01-13
NZ515619A (en) 2003-05-30
IS6162A (is) 2001-11-15
CZ20014366A3 (cs) 2002-11-13
EP1192131B1 (en) 2004-08-04
EP1192131A1 (en) 2002-04-03
EA004405B1 (ru) 2004-04-29
CR6530A (es) 2004-03-24
SK17622001A3 (sk) 2003-06-03
CA2373394A1 (en) 2000-12-21
ES2223531T3 (es) 2005-03-01
UA64842C2 (uk) 2004-03-15
NO20015992D0 (no) 2001-12-07
ATE272623T1 (de) 2004-08-15

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