NO20014963L - Cycloalkyl-substituerte benzimidazoler, samt fremstilling og anvendelse derav - Google Patents

Cycloalkyl-substituerte benzimidazoler, samt fremstilling og anvendelse derav

Info

Publication number
NO20014963L
NO20014963L NO20014963A NO20014963A NO20014963L NO 20014963 L NO20014963 L NO 20014963L NO 20014963 A NO20014963 A NO 20014963A NO 20014963 A NO20014963 A NO 20014963A NO 20014963 L NO20014963 L NO 20014963L
Authority
NO
Norway
Prior art keywords
cycloalkyl
preparation
well
substituted benzimidazoles
benzimidazoles
Prior art date
Application number
NO20014963A
Other languages
English (en)
Norwegian (no)
Other versions
NO20014963D0 (no
Inventor
Wilfried Lubisch
Michael Kock
Thomas Hoeger
Roland Grandel
Sabine Schult
Reinhold Mueller
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20014963D0 publication Critical patent/NO20014963D0/no
Publication of NO20014963L publication Critical patent/NO20014963L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20014963A 1999-04-22 2001-10-12 Cycloalkyl-substituerte benzimidazoler, samt fremstilling og anvendelse derav NO20014963L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918211A DE19918211A1 (de) 1999-04-22 1999-04-22 Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
PCT/EP2000/003231 WO2000064878A1 (fr) 1999-04-22 2000-04-11 Benzimidazoles a substitution cycloalkyle, et leur utilisation comme inhibiteurs de la parp

Publications (2)

Publication Number Publication Date
NO20014963D0 NO20014963D0 (no) 2001-10-12
NO20014963L true NO20014963L (no) 2001-11-13

Family

ID=7905444

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014963A NO20014963L (no) 1999-04-22 2001-10-12 Cycloalkyl-substituerte benzimidazoler, samt fremstilling og anvendelse derav

Country Status (27)

Country Link
US (1) US6737421B1 (fr)
EP (1) EP1171424B1 (fr)
JP (1) JP4002067B2 (fr)
KR (1) KR20020002435A (fr)
CN (1) CN1349510A (fr)
AR (1) AR023754A1 (fr)
AT (1) ATE432264T1 (fr)
AU (1) AU3965900A (fr)
BG (1) BG65513B1 (fr)
BR (1) BR0009948A (fr)
CA (1) CA2371174C (fr)
CO (1) CO5170500A1 (fr)
CZ (1) CZ20013775A3 (fr)
DE (2) DE19918211A1 (fr)
ES (1) ES2325674T3 (fr)
HK (1) HK1045513A1 (fr)
HU (1) HUP0200859A3 (fr)
IL (1) IL145882A0 (fr)
NO (1) NO20014963L (fr)
NZ (1) NZ514930A (fr)
PL (1) PL198919B1 (fr)
RU (1) RU2001131550A (fr)
SK (1) SK15222001A3 (fr)
TR (1) TR200103047T2 (fr)
TW (1) TWI278452B (fr)
WO (1) WO2000064878A1 (fr)
ZA (1) ZA200108204B (fr)

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BR0208010A (pt) 2001-03-12 2004-12-21 Avanir Pharmaceuticals Composto de benzimidazol para modulação de ige e inibição de proliferação celular
WO2004013333A2 (fr) 2002-07-26 2004-02-12 Basf Plant Science Gmbh Nouveaux procedes de selection
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
ES2380917T3 (es) 2002-10-01 2012-05-21 Mitsubishi Tanabe Pharma Corporation Compuestos de isoquinolina y su uso medicinal
EP1566380B1 (fr) 2002-11-22 2012-01-11 Mitsubishi Tanabe Pharma Corporation Composes d'isoquinolinone et leur utilisation a des fins medicinales
US9737511B2 (en) * 2004-05-24 2017-08-22 Geoffrey C. GURTNER Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
CA2568134A1 (fr) * 2004-05-24 2005-12-08 New York University Methode de traitement ou de prevention d'effets pathologiques d'augmentations aigues de l'hyperglycemie et/ou d'augmentations aigues de flux d'acides gras libres
EP2045327B8 (fr) 2005-03-08 2012-03-14 BASF Plant Science GmbH Expression à amélioration de séquences d'intron
WO2006110683A1 (fr) * 2005-04-11 2006-10-19 Abbott Laboratories 1h-benzimidazole-4-carboxamides 2-substitues en tant qu'inhibiteurs de parp
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
ES2378692T3 (es) 2005-09-29 2012-04-17 Abbott Laboratories Las 1H-benzimidazol-4-carboxamidas sustituidas con fenilo en la posición 2 son potentes inhibidores de PARP
JP5162465B2 (ja) * 2005-11-15 2013-03-13 アボット・ラボラトリーズ 置換１ｈ−ベンズイミダゾール−４−カルボキサミド類は強力なｐａｒｐ阻害薬である
JP4611441B2 (ja) * 2006-04-03 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール及びベンゾトリアゾール誘導体
WO2007131016A2 (fr) * 2006-05-02 2007-11-15 Abbott Laboratories 1h-benzimidazole-4-carboxamides substitués servant de puissants inhibiteurs de parp
EP2336120B1 (fr) 2007-01-10 2014-07-16 MSD Italia S.r.l. Combinaisons contenant indazoles à substitution amide utilisés comme inhibiteurs de la poly(ADP-ribose)polymérase (PARP)
WO2008154129A1 (fr) * 2007-06-08 2008-12-18 Bausch & Lomb Incorporated Compositions pharmaceutiques et procédé permettant de traiter, réduire, améliorer, atténuer, ou prévenir la sécheresse oculaire
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
US20090062268A1 (en) * 2007-08-27 2009-03-05 Lead Therapeutics, Inc. Novel inhibitors of poly(adp-ribose)polymerase (parp)
BRPI0906020A2 (pt) 2008-01-08 2015-06-30 Merck Sharp & Dohme Sais farmaceuticamente aceitáveis de 2-{4-[ (3s) - piperidina-3-il ] fenil} -2h - indazol - 7 - carboxamida, uso e método de tratamento
EP2286232B1 (fr) * 2008-05-16 2012-02-29 Cellzome Ag Procédés pour l'identification de molécules entrant en interaction avec parp et pour la purification de protéines parp
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
WO2010083199A1 (fr) * 2009-01-19 2010-07-22 Abbott Laboratories Inhibiteurs benzthiazole de la poly(adp-ribose)polymérase
CN102725412B (zh) 2009-11-27 2017-09-22 巴斯夫植物科学有限公司 优化的内切核酸酶及其用途
CA2781693C (fr) 2009-11-27 2018-12-18 Basf Plant Science Company Gmbh Endonucleases chimeriques et utilisations de celles-ci
EP2504430A4 (fr) 2009-11-27 2013-06-05 Basf Plant Science Co Gmbh Endonucléases chimériques et utilisations de celles-ci
US20130116284A1 (en) 2010-05-10 2013-05-09 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
RU2476224C2 (ru) * 2010-11-12 2013-02-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук (ФГБУ "НИИ фармакологии имени В.В. Закусова" РАМН) Лекарственное средство с кардиопротективной активностью
JP5902299B2 (ja) * 2011-07-26 2016-04-13 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Ｐａｒｐ−１阻害剤としての３−オキソ−２，３−ジヒドロ−１ｈ−インダゾール−４−カルボキサミド誘導体
PL2748111T3 (pl) 2011-11-17 2015-06-30 Alexander Schluttig Urządzenie i sposób wytwarzania sterylnej wody za pomocą sterylnego filtra cieczy z poprzecznym przepływem
JP6171003B2 (ja) * 2012-05-24 2017-07-26 ノバルティス アーゲー ピロロピロリジノン化合物
CA2977685C (fr) 2015-03-02 2024-02-20 Sinai Health System Facteurs de recombinaison homologue
DE102015006278B4 (de) 2015-05-15 2021-09-09 Alexander Schluttig Selbstdesinfizierender Geruchsverschluss
WO2019055490A1 (fr) 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University Conditionnement de tissu irradié pour rétention de greffe de graisse
WO2019101188A1 (fr) 2017-11-25 2019-05-31 Beigene, Ltd. Nouveaux benzoimidazoles en tant qu'inhibiteurs sélectifs de l'indoléamine 2, 3-dioxygénases
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN113891880A (zh) * 2019-05-22 2022-01-04 百济神州有限公司 作为吲哚胺2,3-双加氧酶的选择性抑制剂的酰胺取代的咪唑并化合物

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Also Published As

Publication number Publication date
AU3965900A (en) 2000-11-10
BG65513B1 (bg) 2008-10-31
CA2371174C (fr) 2007-02-20
TWI278452B (en) 2007-04-11
PL198919B1 (pl) 2008-07-31
CZ20013775A3 (cs) 2002-10-16
HUP0200859A3 (en) 2002-12-28
NO20014963D0 (no) 2001-10-12
HUP0200859A2 (hu) 2002-11-28
BG105993A (en) 2002-05-31
SK15222001A3 (sk) 2002-06-04
JP4002067B2 (ja) 2007-10-31
AR023754A1 (es) 2002-09-04
IL145882A0 (en) 2002-07-25
BR0009948A (pt) 2002-01-08
CA2371174A1 (fr) 2000-11-02
NZ514930A (en) 2003-10-31
ZA200108204B (en) 2004-05-26
TR200103047T2 (tr) 2002-05-21
DE19918211A1 (de) 2000-10-26
US6737421B1 (en) 2004-05-18
EP1171424A1 (fr) 2002-01-16
PL351557A1 (en) 2003-05-05
CO5170500A1 (es) 2002-06-27
JP2002543066A (ja) 2002-12-17
HK1045513A1 (zh) 2002-11-29
CN1349510A (zh) 2002-05-15
WO2000064878A1 (fr) 2000-11-02
EP1171424B1 (fr) 2009-05-27
KR20020002435A (ko) 2002-01-09
RU2001131550A (ru) 2004-02-27
ES2325674T3 (es) 2009-09-14
ATE432264T1 (de) 2009-06-15
DE50015651D1 (de) 2009-07-09

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