NO20014948D0 - Indigoidbisindolderivater - Google Patents
IndigoidbisindolderivaterInfo
- Publication number
- NO20014948D0 NO20014948D0 NO20014948A NO20014948A NO20014948D0 NO 20014948 D0 NO20014948 D0 NO 20014948D0 NO 20014948 A NO20014948 A NO 20014948A NO 20014948 A NO20014948 A NO 20014948A NO 20014948 D0 NO20014948 D0 NO 20014948D0
- Authority
- NO
- Norway
- Prior art keywords
- indigoidbisindolderivater
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99106207 | 1999-04-12 | ||
EP99107429 | 1999-04-27 | ||
PCT/EP2000/003285 WO2000061555A1 (en) | 1999-04-12 | 2000-04-12 | Indigoid bisindole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20014948L NO20014948L (no) | 2001-10-11 |
NO20014948D0 true NO20014948D0 (no) | 2001-10-11 |
Family
ID=26152940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20014948A NO20014948D0 (no) | 1999-04-12 | 2001-10-11 | Indigoidbisindolderivater |
Country Status (21)
Country | Link |
---|---|
US (1) | US6987092B1 (ru) |
EP (1) | EP1169305A1 (ru) |
JP (1) | JP2002541244A (ru) |
KR (1) | KR20010112424A (ru) |
CN (1) | CN1355789A (ru) |
AU (1) | AU4117800A (ru) |
BG (1) | BG105974A (ru) |
BR (1) | BR0009770A (ru) |
CA (1) | CA2369670A1 (ru) |
CZ (1) | CZ20013555A3 (ru) |
EA (1) | EA200101046A1 (ru) |
HK (1) | HK1041256A1 (ru) |
HR (1) | HRP20010735A2 (ru) |
HU (1) | HUP0200724A3 (ru) |
IL (1) | IL145743A0 (ru) |
MX (1) | MXPA01010214A (ru) |
NO (1) | NO20014948D0 (ru) |
NZ (1) | NZ514663A (ru) |
PL (1) | PL351261A1 (ru) |
SK (1) | SK14272001A3 (ru) |
WO (1) | WO2000061555A1 (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01010436A (es) | 1999-04-12 | 2002-09-18 | Eisenbrand Gerhard | El uso de una membrana celular para la penetracion de derivados bisindol indigoides. |
DE10053474A1 (de) * | 2000-10-24 | 2002-05-02 | Schering Ag | Schwefelhaltige Indirubinderivate, deren Herstellung und Verwendung |
DE10061162A1 (de) * | 2000-11-30 | 2002-07-11 | Schering Ag | Aryl-substituierte Indirubinderivate, deren Herstellung und Verwendung |
DE10114138C2 (de) * | 2001-03-16 | 2003-03-27 | Schering Ag | Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit |
DE10125763A1 (de) * | 2001-05-17 | 2002-11-28 | Schering Ag | Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren |
DE10129028A1 (de) * | 2001-06-11 | 2003-01-02 | Schering Ag | Lösliche Cdk-inhibitorische Indirubinderivate |
US7582670B2 (en) | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
CA2469649C (en) * | 2001-12-13 | 2011-05-03 | Natrogen Therapeutics, Inc. | Derivatives of isoindigo, indigo and indirubin and use in treating cancer |
US6566341B1 (en) * | 2001-12-13 | 2003-05-20 | Natrogen Therapeutics, Inc. | Derivative of isoindigo, indigo and indirubin for the treatment of cancer |
US20050154046A1 (en) | 2004-01-12 | 2005-07-14 | Longgui Wang | Methods of treating an inflammatory-related disease |
US8563525B2 (en) | 2004-01-12 | 2013-10-22 | Natrogen Therapeutics International, Inc. | Methods of treating an inflammatory-related disease |
EP1340745A1 (en) * | 2002-02-20 | 2003-09-03 | Gerhard Prof. Dr. Eisenbrand | Indirubin derivatives and their use for the treatment of cancer |
CN1199946C (zh) * | 2002-10-29 | 2005-05-04 | 无锡杰西医药科技有限公司 | 一种特异性吲哚类化合物及制备方法与其在治疗和预防癌症等疾病中的应用 |
US20120070518A1 (en) * | 2004-01-12 | 2012-03-22 | Natrogen Therapeutics International, Inc. | Methods and compositions for treating psoriasis |
KR100588803B1 (ko) * | 2004-01-27 | 2006-06-12 | 학교법인조선대학교 | 암세포주에 항암활성을 지닌 인디루빈 유도체 |
AU2005239814B2 (en) * | 2004-05-12 | 2010-06-17 | Bayer Cropscience Ag | Plant growth regulation |
CA2633069A1 (en) * | 2005-12-23 | 2007-09-07 | Centre National De La Recherche Scientifique (Cnrs) | New 3'-, 7-substituted indirubins and their applications |
US8518903B2 (en) | 2007-04-19 | 2013-08-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Use of toll-like receptor-9 agonists |
CN101074229B (zh) * | 2007-06-08 | 2010-09-01 | 无锡杰西医药科技有限公司 | 7-氮杂靛玉红和7-氮杂异靛蓝衍生物制备及其药学用途 |
ATE529402T1 (de) | 2008-08-01 | 2011-11-15 | Centre Nat Rech Scient | 3',6-substituierte indirubine und ihre biologischen anwendungen |
EP2199292A1 (en) | 2008-12-22 | 2010-06-23 | Technische Universität Kaiserlautern | 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament |
WO2010072399A1 (en) | 2008-12-22 | 2010-07-01 | Gerhard Eisenbrand | 7-azaindirubins, 7'azaindirubins, 7,7'-diazaindirubins and the corresponding 3'-oxime ether derivatives thereof, their production and use as a medicament |
US9072760B2 (en) | 2010-09-24 | 2015-07-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | TLR4 inhibitors for the treatment of human infectious and inflammatory disorders |
WO2012040719A2 (en) * | 2010-09-24 | 2012-03-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Novel tlr4 inhibitors for the treatment of human infectious and inflammatory disorders |
US10668092B2 (en) | 2010-09-24 | 2020-06-02 | The John Hopkins University | Compositions and methods for treatment of inflammatory disorders |
WO2012088425A2 (en) | 2010-12-22 | 2012-06-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Gap junction-enhancing agents for treatment of necrotizing enterocolitis and inflammatory bowel disease |
JP6019412B2 (ja) * | 2011-07-15 | 2016-11-02 | 学校法人日本大学 | 悪性腫瘍に対する高選択的細胞毒性を有するインディルビン誘導体 |
US8524121B2 (en) * | 2012-01-27 | 2013-09-03 | Xerox Corporation | Bi-indoline-dithione polymers |
AU2013234955A1 (en) | 2012-03-23 | 2014-11-13 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
WO2014052453A1 (en) | 2012-09-25 | 2014-04-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Oral therapy of necrotizing enterocolitis |
CN103333161B (zh) * | 2013-05-28 | 2015-09-30 | 滁州市洛达生物科技有限公司 | 1’-氧代靛玉红的制备和用途 |
KR101855423B1 (ko) * | 2017-04-18 | 2018-05-09 | 주식회사 씨케이바이오텍 | 인디루빈 유도체를 유효성분으로 포함하는 약학 조성물 |
CA3080900C (en) * | 2017-10-31 | 2022-10-25 | Pelemed Co., Ltd. | Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer |
KR102326617B1 (ko) | 2019-06-20 | 2021-11-15 | 서울대학교산학협력단 | 인돌렌인온의 제조 방법 및 인돌렌인온 합성을 통한 인디루빈 유도체의 제조 방법 |
CN110590640B (zh) * | 2019-06-28 | 2020-12-15 | 贵州医科大学 | 一种靛玉红衍生物及其作为cdk/hdac双靶标抑制剂的应用 |
WO2021090172A1 (en) * | 2019-11-04 | 2021-05-14 | Ck Biotechnology Co. | Compositions and methods for suppressing and/or treating neurodegenerative diseases and/or a clinical condition thereof |
WO2021112626A1 (ko) * | 2019-12-06 | 2021-06-10 | 주식회사 펠레메드 | 신규한 인디루빈 유도체 및 이의 용도 |
EP4329748A1 (en) * | 2021-04-29 | 2024-03-06 | Jawaharlal Nehru Centre For Advanced Scientific Research | Indirubin compounds and methods thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS609022B2 (ja) * | 1981-06-19 | 1985-03-07 | イスクラ産業株式会社 | インジルビン誘導体およびそれを含有する抗腫瘍剤 |
JPS609023B2 (ja) * | 1981-06-19 | 1985-03-07 | イスクラ産業株式会社 | インジルビン誘導体およびそれを含有する抗腫瘍剤 |
JPS617254A (ja) * | 1984-06-20 | 1986-01-13 | Isukura Sangyo Kk | ビスインドリノンおよびそれを主成分とする制癌剤 |
HU198946B (en) | 1985-06-12 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing new bisindole derivatives with antitumour action and pharmaceutical compositions comprising same |
JPH03223363A (ja) * | 1989-12-06 | 1991-10-02 | Mitsui Toatsu Chem Inc | ロープ染色用染料および染料組成物、これらを用いる染色法、ならびに染色物 |
AU762830B2 (en) | 1998-05-29 | 2003-07-03 | Cnrs (Centre National De Recherche Scientifique) France Innovation Scientifique Et Transfert | Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases |
EP0966963A1 (en) * | 1998-05-29 | 1999-12-29 | Gerhard Prof. Dr. Eisenbrand | Use of indigoid bisindole derivatives as CDK1 inhibitors |
-
2000
- 2000-04-12 EA EA200101046A patent/EA200101046A1/ru unknown
- 2000-04-12 WO PCT/EP2000/003285 patent/WO2000061555A1/en not_active Application Discontinuation
- 2000-04-12 CN CN00808852A patent/CN1355789A/zh active Pending
- 2000-04-12 CZ CZ20013555A patent/CZ20013555A3/cs unknown
- 2000-04-12 IL IL14574300A patent/IL145743A0/xx unknown
- 2000-04-12 US US09/958,476 patent/US6987092B1/en not_active Expired - Fee Related
- 2000-04-12 KR KR1020017013056A patent/KR20010112424A/ko not_active Application Discontinuation
- 2000-04-12 CA CA002369670A patent/CA2369670A1/en not_active Abandoned
- 2000-04-12 SK SK1427-2001A patent/SK14272001A3/sk unknown
- 2000-04-12 PL PL00351261A patent/PL351261A1/xx not_active Application Discontinuation
- 2000-04-12 BR BR0009770-5A patent/BR0009770A/pt not_active Application Discontinuation
- 2000-04-12 NZ NZ514663A patent/NZ514663A/xx unknown
- 2000-04-12 MX MXPA01010214A patent/MXPA01010214A/es unknown
- 2000-04-12 AU AU41178/00A patent/AU4117800A/en not_active Abandoned
- 2000-04-12 JP JP2000610830A patent/JP2002541244A/ja active Pending
- 2000-04-12 HU HU0200724A patent/HUP0200724A3/hu unknown
- 2000-04-12 EP EP00920695A patent/EP1169305A1/en not_active Withdrawn
-
2001
- 2001-10-03 BG BG105974A patent/BG105974A/bg unknown
- 2001-10-11 NO NO20014948A patent/NO20014948D0/no not_active Application Discontinuation
- 2001-10-11 HR HR20010735A patent/HRP20010735A2/hr not_active Application Discontinuation
-
2002
- 2002-01-14 HK HK02100234.4A patent/HK1041256A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
NO20014948L (no) | 2001-10-11 |
BG105974A (bg) | 2002-06-28 |
NZ514663A (en) | 2002-09-27 |
HRP20010735A2 (en) | 2002-12-31 |
CZ20013555A3 (cs) | 2002-05-15 |
HK1041256A1 (zh) | 2002-07-05 |
WO2000061555A1 (en) | 2000-10-19 |
JP2002541244A (ja) | 2002-12-03 |
IL145743A0 (en) | 2002-07-25 |
CA2369670A1 (en) | 2000-10-19 |
AU4117800A (en) | 2000-11-14 |
KR20010112424A (ko) | 2001-12-20 |
CN1355789A (zh) | 2002-06-26 |
EP1169305A1 (en) | 2002-01-09 |
PL351261A1 (en) | 2003-04-07 |
US6987092B1 (en) | 2006-01-17 |
MXPA01010214A (es) | 2002-03-27 |
HUP0200724A3 (en) | 2002-10-28 |
SK14272001A3 (sk) | 2002-05-09 |
BR0009770A (pt) | 2002-01-08 |
EA200101046A1 (ru) | 2002-04-25 |
HUP0200724A2 (hu) | 2002-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |