NO180049C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-substituerte-8-usubstituerte-9-deazaguaniner - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-substituerte-8-usubstituerte-9-deazaguaniner

Info

Publication number
NO180049C
NO180049C NO913332A NO913332A NO180049C NO 180049 C NO180049 C NO 180049C NO 913332 A NO913332 A NO 913332A NO 913332 A NO913332 A NO 913332A NO 180049 C NO180049 C NO 180049C
Authority
NO
Norway
Prior art keywords
alkyl
trifluoromethyl
deazaguanines
unsubstituted
substituted
Prior art date
Application number
NO913332A
Other languages
English (en)
Norwegian (no)
Other versions
NO180049B (no
NO913332L (no
NO913332D0 (no
Inventor
John A Secrist
Mark David Erion
John A Montgomery
Steven E Ealick
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Publication of NO913332L publication Critical patent/NO913332L/no
Publication of NO913332D0 publication Critical patent/NO913332D0/no
Publication of NO180049B publication Critical patent/NO180049B/no
Publication of NO180049C publication Critical patent/NO180049C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO913332A 1989-02-27 1991-08-26 Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-substituerte-8-usubstituerte-9-deazaguaniner NO180049C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31606389A 1989-02-27 1989-02-27
PCT/US1990/001021 WO1990010631A1 (en) 1989-02-27 1990-02-27 9-substituted-8-unsubstituted-9-deazaguanines

Publications (4)

Publication Number Publication Date
NO913332L NO913332L (no) 1991-08-26
NO913332D0 NO913332D0 (no) 1991-08-26
NO180049B NO180049B (no) 1996-10-28
NO180049C true NO180049C (no) 1997-02-05

Family

ID=23227309

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913332A NO180049C (no) 1989-02-27 1991-08-26 Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-substituerte-8-usubstituerte-9-deazaguaniner

Country Status (15)

Country Link
US (2) US5565463A (de)
EP (1) EP0460116B1 (de)
JP (1) JP2760364B2 (de)
KR (1) KR100208315B1 (de)
AT (1) ATE157363T1 (de)
AU (1) AU640649B2 (de)
CA (1) CA2047216C (de)
DE (1) DE69031337T2 (de)
DK (1) DK0460116T3 (de)
ES (1) ES2106732T3 (de)
FI (1) FI95259C (de)
HU (1) HU217870B (de)
NO (1) NO180049C (de)
RU (1) RU2093513C1 (de)
WO (1) WO1990010631A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2866478B2 (ja) * 1989-10-31 1999-03-08 バイオクリスト・ファーマシューティカルズ・インコーポレイテッド プリンヌクレオシドホスホリラーゼの阻害剤
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5236926A (en) * 1992-02-03 1993-08-17 Warner-Lambert Company 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions
AU6855594A (en) 1993-06-30 1995-01-24 Biocryst Pharmaceuticals, Inc. 9-deazahypoxanthines as pnp inhibitors
US5650511A (en) * 1995-12-12 1997-07-22 Biocryst Pharmaceuticals, Inc. Process for the preparation of 9-deazaguanine derivatives
JP2002500658A (ja) * 1997-05-29 2002-01-08 ノバルティス アクチエンゲゼルシャフト ２−アミノ−７−（１−置換−２−ヒドロキシエチル）−３，５−ジヒドロピロロ［３，２−ｄ］ピリミジン−４−オン
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
US6174888B1 (en) 1998-05-28 2001-01-16 Novartis Ag 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
US7763257B2 (en) 2004-12-09 2010-07-27 Christina Juneau Compositions comprising transforming growth factor (TGF)-β1 and TGF-β2 in admixture of proteins obtained from dairy products
UA104579C2 (uk) 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
WO2014205199A2 (en) 2013-06-22 2014-12-24 Nitor Therapeutics Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
WO2020186187A1 (en) 2019-03-13 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772606A (en) * 1985-08-22 1988-09-20 Warner-Lambert Company Purine derivatives
IL76546A (en) * 1984-10-12 1988-12-30 Warner Lambert Co 9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
US4923872A (en) * 1986-08-26 1990-05-08 Warner-Lambert Co. Analogues of pyrrolo[3,2d]pyrimidin-4-ones
CA1294960C (en) * 1986-10-24 1992-01-28 Thomas C. Malone 7-deazaguanines as immunomodulators
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
EP0374096B1 (de) * 1988-12-14 1992-12-02 Ciba-Geigy Ag 2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür

Also Published As

Publication number Publication date
FI95259C (fi) 1996-01-10
CA2047216A1 (en) 1990-08-28
NO180049B (no) 1996-10-28
JP2760364B2 (ja) 1998-05-28
KR100208315B1 (ko) 1999-07-15
CA2047216C (en) 1999-03-30
ATE157363T1 (de) 1997-09-15
EP0460116B1 (de) 1997-08-27
JPH04503675A (ja) 1992-07-02
DE69031337D1 (de) 1997-10-02
HUT58737A (en) 1992-03-30
NO913332L (no) 1991-08-26
EP0460116A1 (de) 1991-12-11
AU5524890A (en) 1990-10-09
ES2106732T3 (es) 1997-11-16
EP0460116A4 (en) 1992-05-13
KR920701209A (ko) 1992-08-11
US5565463A (en) 1996-10-15
RU2093513C1 (ru) 1997-10-20
FI914015A0 (fi) 1991-08-26
US5721240A (en) 1998-02-24
AU640649B2 (en) 1993-09-02
DK0460116T3 (da) 1998-03-30
DE69031337T2 (de) 1998-03-05
WO1990010631A1 (en) 1990-09-20
NO913332D0 (no) 1991-08-26
HU217870B (hu) 2000-04-28
FI95259B (fi) 1995-09-29

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