NO177863C - Method for Preparation of Recombinant Human IFN Type I, IFN1, IFN-Pseudo-2, -3, and -4, and Expression Vectors - Google Patents

Method for Preparation of Recombinant Human IFN Type I, IFN1, IFN-Pseudo-2, -3, and -4, and Expression Vectors

Info

Publication number
NO177863C
NO177863C NO853012A NO853012A NO177863C NO 177863 C NO177863 C NO 177863C NO 853012 A NO853012 A NO 853012A NO 853012 A NO853012 A NO 853012A NO 177863 C NO177863 C NO 177863C
Authority
NO
Norway
Prior art keywords
ifn
ifn1
pseudo
preparation
expression vectors
Prior art date
Application number
NO853012A
Other languages
Norwegian (no)
Other versions
NO853012L (en
NO177863B (en
Inventor
Rudolf Hauptmann
Peter Meindl
Eva Dworkin-Rastl
Gunther Adolf
Peter Swetly
Christiann Pieler
Norbert Hauel
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3428370A external-priority patent/DE3428370A1/en
Priority claimed from DE19853505060 external-priority patent/DE3505060A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO853012L publication Critical patent/NO853012L/en
Publication of NO177863B publication Critical patent/NO177863B/en
Publication of NO177863C publication Critical patent/NO177863C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The type I interferon peptides encoded by the genetic DNA sequences are called omega-interferons and are produced using appropriate expression vehicles and organisms.
NO853012A 1984-08-01 1985-07-30 Method for Preparation of Recombinant Human IFN Type I, IFN1, IFN-Pseudo-2, -3, and -4, and Expression Vectors NO177863C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3428370A DE3428370A1 (en) 1984-08-01 1984-08-01 Interferon, genetic sequences which code therefor, and organisms producing these
DE19853505060 DE3505060A1 (en) 1985-02-14 1985-02-14 Type I interferons, genetic sequences which code therefor, and organisms producing these

Publications (3)

Publication Number Publication Date
NO853012L NO853012L (en) 1986-02-03
NO177863B NO177863B (en) 1995-08-28
NO177863C true NO177863C (en) 1995-12-06

Family

ID=25823496

Family Applications (1)

Application Number Title Priority Date Filing Date
NO853012A NO177863C (en) 1984-08-01 1985-07-30 Method for Preparation of Recombinant Human IFN Type I, IFN1, IFN-Pseudo-2, -3, and -4, and Expression Vectors

Country Status (21)

Country Link
EP (1) EP0170204B1 (en)
JP (2) JP2566909B2 (en)
KR (1) KR0136799B1 (en)
AT (1) ATE67786T1 (en)
AU (1) AU600653B2 (en)
BG (1) BG60445B2 (en)
CA (1) CA1340184C (en)
DD (1) DD246318A5 (en)
DE (1) DE3584198D1 (en)
DK (1) DK175194B1 (en)
ES (2) ES8609475A1 (en)
FI (1) FI90667C (en)
GR (1) GR851866B (en)
HK (1) HK187896A (en)
HU (1) HU205779B (en)
IE (1) IE58942B1 (en)
IL (1) IL75963A (en)
MX (1) MX9203645A (en)
NO (1) NO177863C (en)
NZ (1) NZ212937A (en)
PT (1) PT80901B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231176A (en) * 1984-08-27 1993-07-27 Genentech, Inc. Distinct family DNA encoding of human leukocyte interferons
EP0490233A1 (en) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonal antibodies against Bgl III-hybrid interferons, their use and process for preparing them
DE3607835A1 (en) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int HYBRID INTERFERONS, THEIR USE AS MEDICINAL PRODUCTS AND AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF ANTIBODIES AND THE USE THEREOF AND METHOD FOR THEIR PRODUCTION
US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3633323A1 (en) * 1986-10-01 1988-04-07 Boehringer Ingelheim Int NEW MONOCLONAL ANTIBODIES AGAINST IFN-OMEGA, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CLEANING AND DETECTING IFN-OMEGA
DE3635867A1 (en) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int NEW YEAR EXPRESSION VECTORS FOR IFN-OMEGA, METHOD FOR THEIR PRODUCTION AND USE THEREOF
WO1999026663A2 (en) * 1997-11-20 1999-06-03 Vical, Inc. Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor
WO2000040273A2 (en) * 1999-01-08 2000-07-13 Vical Incorporated Treatment of viral diseases using an interferon omega expressing polynucleotide
CA2477794C (en) 2002-03-07 2013-08-20 Eidgenoessische Technische Hochschule Zuerich System and method for the production of recombinant glycosylated proteins in a prokaryotic host
KR101495616B1 (en) * 2002-03-07 2015-02-26 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 System and method for the production of recombinant glycosylated protein in a prokaryotic host
MXPA05010773A (en) 2003-04-09 2005-12-12 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods.
WO2004096852A1 (en) * 2003-04-25 2004-11-11 The Institute Of Microbiology And Epidemiology, Academy Of Military Medical Sciemces, Pla A RECOMBINANT HUMAN INTERFERON ϖ, THE METHOD FOR EXPRESSING IT AND THE USES OF IT
PT1888761E (en) 2005-05-11 2011-01-03 Eth Zuerich Recombinant n-glycosylated proteins from procaryotic cells
CN101983070B (en) 2008-02-20 2016-03-30 格林考瓦因有限公司 The recombinant N-glycosylated proteins that origin comes from prokaryotic cell prepares bioconjugates
PT2501406T (en) 2009-11-19 2018-02-21 Glaxosmithkline Biologicals Sa Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells
WO2011138361A1 (en) 2010-05-06 2011-11-10 Glycovaxyn Capsular gram-positive bacteria bioconjugate vaccines
WO2013024156A2 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection
WO2013024158A1 (en) 2011-08-17 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection
WO2014033266A1 (en) 2012-08-31 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1946283A (en) * 1982-08-18 1984-03-07 Cetus Corporation Interferon-alpha 6l
CA1217440A (en) * 1982-08-18 1987-02-03 Michael A. Innis INTERFERON .alpha. 6L
DE3247922A1 (en) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim DNA SEQUENCES, THEIR PRODUCTION, PLASMIDES CONTAINING THESE SEQUENCES AND THE USE THEREOF FOR THE SYNTHESIS OF EUKARYOTIC GENE PRODUCTS IN PROKARYOTS
ATE47864T1 (en) * 1984-08-27 1989-11-15 Genentech Inc MISCELLANEOUS FAMILY OF HUMAN WBC INTERFERONS, COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR PRODUCTION, AND DNA AND TRANSFECTED HOSTS THEREOF.

Also Published As

Publication number Publication date
DK346385A (en) 1986-02-02
EP0170204A3 (en) 1988-02-17
AU4554985A (en) 1986-02-06
JPS61181381A (en) 1986-08-14
DK346385D0 (en) 1985-07-30
JP2567195B2 (en) 1996-12-25
GR851866B (en) 1985-12-02
ES8708013A1 (en) 1987-09-01
FI852956L (en) 1986-02-02
KR0136799B1 (en) 1998-04-25
KR870001310A (en) 1987-03-13
NO853012L (en) 1986-02-03
PT80901A (en) 1985-09-01
HU205779B (en) 1992-06-29
FI852956A0 (en) 1985-07-31
IL75963A (en) 1992-05-25
ES552431A0 (en) 1987-09-01
NO177863B (en) 1995-08-28
DE3584198D1 (en) 1991-10-31
FI90667B (en) 1993-11-30
DD246318A5 (en) 1987-06-03
PT80901B (en) 1989-01-17
ES8609475A1 (en) 1986-08-01
CA1340184C (en) 1998-12-15
HUT39477A (en) 1986-09-29
HK187896A (en) 1996-10-18
FI90667C (en) 1994-03-10
JP2566909B2 (en) 1996-12-25
MX9203645A (en) 1992-09-01
DK175194B1 (en) 2004-07-05
JPH06181771A (en) 1994-07-05
ATE67786T1 (en) 1991-10-15
AU600653B2 (en) 1990-08-23
EP0170204A2 (en) 1986-02-05
IE58942B1 (en) 1993-12-01
IE851906L (en) 1986-02-01
ES545725A0 (en) 1986-08-01
BG60445B2 (en) 1995-03-31
IL75963A0 (en) 1985-12-31
NZ212937A (en) 1991-08-27
EP0170204B1 (en) 1991-09-25

Similar Documents

Publication Publication Date Title
NO177863C (en) Method for Preparation of Recombinant Human IFN Type I, IFN1, IFN-Pseudo-2, -3, and -4, and Expression Vectors
SE8105657L (en) MICROBIAL PREPARATION OF HUMAN FIBROBLAST INTERFERON
AU573523B2 (en) Functional human urokinase proteins
IT8119760A0 (en) POLYPEPTIDE PRODUCED MICROBIOLOGICALLY WITH THE AMINO ACIDS SEQUENCE OF HUMAN INTERFERON, DNA AND PLASMIDS THAT CODE FOR THIS SEQUENCE, MICROORGANISMS THAT CONTAIN THIS GENETIC INFORMATION AND PROCESS FOR THEIR PREPARATION.
DK453782A (en) DNA SEQUENCES, RECOMBINANT PLASMID AND USES THEREOF
GB2171703B (en) Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
IT8119759A0 (en) HUMAN, DNA AND PLASMIDS WHICH PRODUCT POLYPEPTIDE CODE FOR THIS SEQUENCE, MICROBIOLOGICALLY WITH THE SEQUENCE MICROORGANISMS THAT CONTAIN INTERFERON AMINO ACIDS THIS GENETIC INFORMATION AND PROCESS FOR THEIR PREPARATION.
EP0497911A4 (en) Recombinant production of lactoperoxidase
IT8521507A0 (en) CLONING VECTOR, RECOMBINANT DNA MOLECULES, STRAINS OF BACILLUS SUBTILIS TRANSFORMED WITH THE SAID MOLECULES AND METHODS FOR THE EXPRESSION OF HETEROLOGOUS GENES AND PRODUCTION AND SECRETION OF PROTEINS CODED BY THE SAID GENES.
PH31199A (en) Coding, promoter and regulator sequences of irf-1.
SG134394G (en) Genetic sequences, type I interferon peptide coded by them, and these organisms producing the same

Legal Events

Date Code Title Description
MK1K Patent expired