NO175011C - Fremgangsmåte for separering av en blanding av vevplasminogenaktivator (tPA)-arter som har forskjellige molekylvekter - Google Patents

Fremgangsmåte for separering av en blanding av vevplasminogenaktivator (tPA)-arter som har forskjellige molekylvekter

Info

Publication number
NO175011C
NO175011C NO873332A NO873332A NO175011C NO 175011 C NO175011 C NO 175011C NO 873332 A NO873332 A NO 873332A NO 873332 A NO873332 A NO 873332A NO 175011 C NO175011 C NO 175011C
Authority
NO
Norway
Prior art keywords
tpa
species
separating
mixture
molecular weights
Prior art date
Application number
NO873332A
Other languages
English (en)
Other versions
NO873332D0 (no
NO175011B (no
NO873332L (no
Inventor
Mitsuyoshi Morii
Masaharu Ohoka
Toshihiko Suzuki
Katsuyuki Suzuki
Nobuhiro Kawashima
Noriko Morii
Kunizou Mori
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of NO873332D0 publication Critical patent/NO873332D0/no
Publication of NO873332L publication Critical patent/NO873332L/no
Publication of NO175011B publication Critical patent/NO175011B/no
Publication of NO175011C publication Critical patent/NO175011C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO873332A 1986-08-11 1987-08-10 Fremgangsmåte for separering av en blanding av vevplasminogenaktivator (tPA)-arter som har forskjellige molekylvekter NO175011C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61186851A JP2507339B2 (ja) 1986-08-11 1986-08-11 粗ｔＰＡの精製方法

Publications (4)

Publication Number Publication Date
NO873332D0 NO873332D0 (no) 1987-08-10
NO873332L NO873332L (no) 1988-02-12
NO175011B NO175011B (no) 1994-05-09
NO175011C true NO175011C (no) 1994-08-17

Family

ID=16195757

Family Applications (1)

Application Number Title Priority Date Filing Date
NO873332A NO175011C (no) 1986-08-11 1987-08-10 Fremgangsmåte for separering av en blanding av vevplasminogenaktivator (tPA)-arter som har forskjellige molekylvekter

Country Status (10)

Country Link
US (1) US5141863A (no)
EP (1) EP0256836B1 (no)
JP (1) JP2507339B2 (no)
AU (1) AU586756B2 (no)
CA (1) CA1302928C (no)
DE (1) DE3780883T2 (no)
DK (1) DK169680B1 (no)
FI (1) FI88308C (no)
NO (1) NO175011C (no)
ZA (1) ZA875902B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01238534A (ja) * 1988-03-17 1989-09-22 Mitsui Toatsu Chem Inc エンドトキシンの除去方法
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US20020064860A1 (en) * 2000-11-29 2002-05-30 Schering Corporation Method for purifying adenoviruses
WO2009092014A1 (en) * 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of antibodies and antibody fragments by apatite chromatography
US8617863B2 (en) 2008-06-04 2013-12-31 Grifols Therapeutics Inc. Composition, method, and kit for preparing plasmin
PT2403865E (pt) 2009-03-03 2015-11-18 Grifols Therapeutics Inc Métodos de preparação de plasminogénio
US8951807B2 (en) 2010-01-15 2015-02-10 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5881744B2 (ja) 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
CN102286449B (zh) * 2011-05-30 2013-04-03 云南省地方病防治所 鼠疫菌纤溶酶原激活因子Pla的提取与纯化方法
WO2013180933A1 (en) 2012-05-30 2013-12-05 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
US10099157B2 (en) 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
WO2015200282A1 (en) 2014-06-23 2015-12-30 Bio-Rad Laboratories, Inc. Apatite pretreatment
CN111909920B (zh) * 2020-08-24 2022-04-15 武汉人福药业有限责任公司 一种重组人组织型纤溶酶原激活剂的表达纯化方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542646A (en) * 1966-11-22 1970-11-24 Green Cross Corp Process for fractionally obtaining urokinase and blood coagulation accelerator in human urine
IL43343A (en) * 1972-10-24 1976-03-31 Lilly Co Eli Production of plasminogen activator
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
JPS55130918A (en) * 1979-03-30 1980-10-11 Toubishi Yakuhin Kogyo Kk Plasminogen-activating agent and its preparation
JPS57146580A (en) * 1981-03-09 1982-09-10 Seikagaku Kogyo Co Ltd Separation and purification of enzyme in human urine
DE3382389D1 (de) * 1982-12-14 1991-10-02 South African Inventions Plasminogenaktivator.
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
US4928620A (en) * 1988-09-01 1990-05-29 Currey Lesley B Seat pedestal mount

Also Published As

Publication number Publication date
FI873470A0 (fi) 1987-08-10
JP2507339B2 (ja) 1996-06-12
DK418487D0 (da) 1987-08-11
AU7666687A (en) 1988-02-18
NO873332D0 (no) 1987-08-10
ZA875902B (en) 1988-02-12
NO175011B (no) 1994-05-09
EP0256836B1 (en) 1992-08-05
CA1302928C (en) 1992-06-09
DE3780883D1 (de) 1992-09-10
DE3780883T2 (de) 1993-02-04
FI88308B (fi) 1993-01-15
EP0256836A1 (en) 1988-02-24
JPS6342687A (ja) 1988-02-23
NO873332L (no) 1988-02-12
US5141863A (en) 1992-08-25
FI873470A (fi) 1988-02-12
AU586756B2 (en) 1989-07-20
FI88308C (fi) 1993-04-26
DK169680B1 (da) 1995-01-09
DK418487A (da) 1988-02-12

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