NO174772C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive piperazinylderivater - Google Patents
Analogifremgangsmåte ved fremstilling av terapeutisk aktive piperazinylderivaterInfo
- Publication number
- NO174772C NO174772C NO895281A NO895281A NO174772C NO 174772 C NO174772 C NO 174772C NO 895281 A NO895281 A NO 895281A NO 895281 A NO895281 A NO 895281A NO 174772 C NO174772 C NO 174772C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- compounds
- therapeutically active
- analogous procedure
- piperazinyl derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888830312A GB8830312D0 (en) | 1988-12-28 | 1988-12-28 | Heterocyclic compounds |
Publications (4)
Publication Number | Publication Date |
---|---|
NO895281D0 NO895281D0 (no) | 1989-12-27 |
NO895281L NO895281L (no) | 1990-06-29 |
NO174772B NO174772B (no) | 1994-03-28 |
NO174772C true NO174772C (no) | 1994-07-06 |
Family
ID=10649223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO895281A NO174772C (no) | 1988-12-28 | 1989-12-27 | Analogifremgangsmåte ved fremstilling av terapeutisk aktive piperazinylderivater |
Country Status (17)
Country | Link |
---|---|
US (1) | US5002948A (fr) |
EP (1) | EP0376607B1 (fr) |
JP (1) | JP2895121B2 (fr) |
AT (1) | ATE102184T1 (fr) |
AU (1) | AU637991B2 (fr) |
CA (1) | CA2006356C (fr) |
DE (1) | DE68913487T2 (fr) |
DK (1) | DK169266B1 (fr) |
ES (1) | ES2062050T3 (fr) |
FI (1) | FI93005C (fr) |
GB (1) | GB8830312D0 (fr) |
IE (1) | IE62668B1 (fr) |
IL (1) | IL92990A (fr) |
NO (1) | NO174772C (fr) |
NZ (1) | NZ231855A (fr) |
PT (1) | PT92728B (fr) |
ZA (1) | ZA899960B (fr) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3923045A1 (de) * | 1989-07-13 | 1991-01-17 | Merck Patent Gmbh | Indolderivate |
EP0465254B1 (fr) * | 1990-07-06 | 1996-11-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Composés condensés de thiophen et leur usage |
US5643784A (en) * | 1990-12-04 | 1997-07-01 | H, Lundbeck A/S | Indan derivatives |
FR2670491B1 (fr) * | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
DE4127849A1 (de) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
CA2084531A1 (fr) * | 1991-12-19 | 1993-06-20 | David W. Smith | Derives antimigraines 4-pyrimidinyle et pyridinyle d'indol-3yl-alkylpiperazines |
DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
ES2050623B1 (es) * | 1992-11-06 | 1994-12-16 | Merck Patent Gmbh | Derivados de 1,4-benzodioxano. |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
KR950704252A (ko) * | 1992-12-21 | 1995-11-17 | 우에하라 아키라 | N-치환 이미다졸 유도체 |
GB9305623D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
RU2118322C1 (ru) * | 1993-07-05 | 1998-08-27 | Дюфар Интернэшнл Рисерч Б.В. | 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли |
DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
US5552402A (en) * | 1994-05-19 | 1996-09-03 | Merck, Sharp & Dohme Ltd. | Five-membered heteroaromatic compounds as 5-HT receptor agonists |
DE19512639A1 (de) | 1995-04-05 | 1996-10-10 | Merck Patent Gmbh | Benzonitrile und -fluoride |
CA2222532A1 (fr) * | 1995-05-31 | 1996-12-05 | Nisshin Flour Milling Co., Ltd. | Derives de l'indazole a groupe amino monocyclique |
JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する1−アリールアルキル−4−(アルコキシピリジニル)−又は4−(アルコキシピリミジニル)ピペラジン誘導体 |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
CA2297825C (fr) * | 1997-07-25 | 2006-03-14 | H. Lundbeck A/S | Derives indole et 2,3-dihydro-indole, leur preparation et utilisation |
AR013206A1 (es) * | 1997-07-25 | 2000-12-13 | Lundbeck & Co As H | Derivados indol y 2,3-dihidroindol, composiciones farmaceuticas que contienen estos compuestos y el uso de dichos compuestos para la preparacion de un medicamento para el tratamiento de desordenes sensibles a la inhibicion de la reabsorcion de serotonina y antagonismo de receptores 5-ht1a. |
JP2002510676A (ja) * | 1998-04-08 | 2002-04-09 | アメリカン・ホーム・プロダクツ・コーポレイション | うつ病治療用のn−アリールオキシエチルアミン誘導体 |
AR022303A1 (es) | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
AU772189B2 (en) * | 1999-08-23 | 2004-04-08 | Solvay Pharmaceuticals B.V. | New phenylpiperazines |
CZ20022319A3 (cs) * | 1999-12-30 | 2002-10-16 | H. Lundbeck A/S | Substituovaná fenylpiperazinová sloučenina a farmaceutický prostředek, který ji obsahuje |
SK11062002A3 (sk) * | 1999-12-30 | 2002-12-03 | H. Lundbeck A/S | Fenylpiperazínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
AR032712A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
WO2002085896A1 (fr) * | 2001-04-24 | 2002-10-31 | Wyeth | Derives azaheterocyclylmethyle antidepresseurs de 2,3-dihydro-1,4-benzodioxane |
US7041683B2 (en) | 2001-04-24 | 2006-05-09 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan |
WO2003007956A1 (fr) | 2001-07-20 | 2003-01-30 | Psychogenics, Inc. | Traitement des troubles de deficit de l'attention/hyperactivite |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
MXPA05006076A (es) * | 2002-12-10 | 2005-08-16 | Merck Patent Gmbh | Derivados de indol y su uso como ligandos 5-ht. |
US7276603B2 (en) * | 2003-05-02 | 2007-10-02 | Wyeth | Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use |
DE10326940A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
JP2007533686A (ja) * | 2004-04-22 | 2007-11-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 性的障害ii治療用の新規医薬組成物 |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
ATE382045T1 (de) * | 2004-05-11 | 2008-01-15 | Egis Gyogyszergyar Nyrt | Indol-2-onderivate zur behandlung von erkrankungen des zentralen nervensystems, erkrankungen des magen-darm-trakts und herzkreislauferkankungen |
EA010154B1 (ru) * | 2004-05-11 | 2008-06-30 | Эгиш Дьёдьсердьяр Нирт. | Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7 |
RS20060623A (en) * | 2004-05-11 | 2008-09-29 | Egis Gyogyszergyar Nyrt., | New piperazine derivatives of dialkyl oxindoles |
HUP0400953A3 (en) | 2004-05-11 | 2008-02-28 | Egis Gyogyszergyar Nyilvanosan | Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use |
US20070219209A1 (en) * | 2004-05-11 | 2007-09-20 | Gyógyszergyár Rt. | Piperazine Derivatives Of Alkyl Oxindoles |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
EP1789048A1 (fr) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Methode de traitement du trouble de l'hyperactivite avec deficit de l'attention |
US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
ATE425754T1 (de) * | 2004-12-07 | 2009-04-15 | Solvay Pharm Bv | Bezdioxan-piperazin-derivate mit einer kombination aus affinitat fur dopamin-d2- rezeptoren und serotonin-wiederaufnahme-stellen |
US20070072870A2 (en) | 2004-12-08 | 2007-03-29 | Solvay Pharmeceuticals B.V. | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
WO2006096435A1 (fr) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques utiles dans le traitement et/ou la prevention de la depression |
WO2006096439A2 (fr) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques destinees au traitement et/ou a la prevention de la schizophrenie et de maladies associees |
EP1858515A2 (fr) * | 2005-03-04 | 2007-11-28 | Boehringer Ingelheim International Gmbh | Compositions pharmaceutiques permettant de traiter et/ou de prevenir les troubles de l'anxiete |
US20070004777A1 (en) * | 2005-03-23 | 2007-01-04 | Bhagwat Shripad S | Methods for treating or preventing acute myelogenous leukemia |
CA2608249A1 (fr) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Methode de traitement de la toxicomanie |
EP1888071A1 (fr) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Procede pour le traitement de dysfonctionnements sexuels d origine medicamenteuse |
US20060264512A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunction due to medical conditions |
PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
WO2007048803A1 (fr) | 2005-10-29 | 2007-05-03 | Boehringer Ingelheim International Gmbh | Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme |
US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
JP2009536176A (ja) * | 2006-05-09 | 2009-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 閉経後の性的欲求障害の治療のためのフリバンセリンの使用 |
US20090312242A1 (en) * | 2006-06-30 | 2009-12-17 | Ramiro Castro | Flibanserin for the treatment of urinary incontinence and related diseases |
EP2043648A1 (fr) * | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Utilisation de flibansérine pour le traitement de troubles sexuels chez les femmes |
CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
AR062320A1 (es) | 2006-08-14 | 2008-10-29 | Boehringer Ingelheim Int | Formulaciones de flibanserina y metodo para fabricarlas |
CN104721168A (zh) | 2006-08-25 | 2015-06-24 | 贝林格尔·英格海姆国际有限公司 | 控制释放系统及其制造方法 |
UY31335A1 (es) * | 2007-09-12 | 2009-04-30 | Tratamiento de sintomas vasomotores | |
CN102574787B (zh) | 2009-07-30 | 2014-12-31 | 新加坡国立大学 | 具有潜在的抗癌活性的小分子异戊二烯基半胱氨酸羧基甲基转移酶抑制剂 |
EP2464227A4 (fr) * | 2009-08-10 | 2013-02-20 | Galenea Corp | Composés et leurs procédés d utilisation |
CN102993186B (zh) * | 2012-12-20 | 2015-11-18 | 北京海步国际医药科技发展有限公司 | 一种新型的哌嗪衍生物 |
EP3027607B1 (fr) | 2013-07-29 | 2020-08-26 | Sunshine Lake Pharma Co., Ltd. | Composés hétéroaryliques substitués et procédés d'utilisation |
US9714232B2 (en) | 2013-12-20 | 2017-07-25 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use thereof |
CN106065018B (zh) * | 2015-04-23 | 2020-04-21 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
WO2016192657A1 (fr) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Composés de pipérazine substitués, leurs procédés d'utilisation et leurs utilisations |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB944443A (fr) * | 1959-09-25 | 1900-01-01 | ||
GB1075156A (en) * | 1963-08-27 | 1967-07-12 | Luso Farmaco Inst | Substituted piperazines |
MC614A1 (fr) * | 1966-04-21 | 1967-05-31 | Cerm Cent Europ Rech Mauvernay | Nouveau composé analgésique et anti-inflammatoire. |
US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
US3678059A (en) * | 1969-10-07 | 1972-07-18 | Ciba Geigy Corp | 3-aminoalkylidene-indazoles |
US3900495A (en) * | 1971-05-27 | 1975-08-19 | American Cyanamid Co | Intermediate indolines |
US3751417A (en) * | 1971-08-12 | 1973-08-07 | American Cyanamid Co | 1-acyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines |
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
FR2475898A1 (fr) * | 1980-02-14 | 1981-08-21 | Andre Buzas | Medicament analgesique contenant de la 1-(3'-benzofuryl)-4-benzylpiperazine et son procede de preparation |
US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4710573A (en) * | 1983-08-22 | 1987-12-01 | Hoechst Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)-and 3-(pyrrolidinyl)-1H-indazoles |
EP0190472B1 (fr) * | 1984-12-21 | 1989-07-12 | Duphar International Research B.V | Médicaments à activité antipsychotique |
DE3604949A1 (de) * | 1986-02-17 | 1987-08-20 | Merck Patent Gmbh | Hydroxyindolester |
US4831156A (en) * | 1987-09-30 | 1989-05-16 | The University Of Tennessee Research Corp. | 3-substituted 2-alkyl indole derivatives |
US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
DE3923045A1 (de) * | 1989-07-13 | 1991-01-17 | Merck Patent Gmbh | Indolderivate |
-
1988
- 1988-12-28 GB GB888830312A patent/GB8830312D0/en active Pending
-
1989
- 1989-12-12 IE IE397689A patent/IE62668B1/en not_active IP Right Cessation
- 1989-12-19 NZ NZ231855A patent/NZ231855A/en unknown
- 1989-12-19 DK DK645689A patent/DK169266B1/da not_active IP Right Cessation
- 1989-12-20 AT AT89313371T patent/ATE102184T1/de not_active IP Right Cessation
- 1989-12-20 ES ES89313371T patent/ES2062050T3/es not_active Expired - Lifetime
- 1989-12-20 DE DE68913487T patent/DE68913487T2/de not_active Expired - Fee Related
- 1989-12-20 EP EP89313371A patent/EP0376607B1/fr not_active Expired - Lifetime
- 1989-12-21 CA CA002006356A patent/CA2006356C/fr not_active Expired - Lifetime
- 1989-12-22 AU AU47198/89A patent/AU637991B2/en not_active Ceased
- 1989-12-26 US US07/456,938 patent/US5002948A/en not_active Expired - Lifetime
- 1989-12-27 PT PT92728A patent/PT92728B/pt not_active IP Right Cessation
- 1989-12-27 NO NO895281A patent/NO174772C/no not_active IP Right Cessation
- 1989-12-27 JP JP1336755A patent/JP2895121B2/ja not_active Expired - Fee Related
- 1989-12-28 ZA ZA899960A patent/ZA899960B/xx unknown
- 1989-12-28 FI FI896300A patent/FI93005C/fi active IP Right Grant
-
1990
- 1990-01-07 IL IL9299090A patent/IL92990A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK169266B1 (da) | 1994-09-26 |
CA2006356A1 (fr) | 1990-06-28 |
FI896300A0 (fi) | 1989-12-28 |
DE68913487D1 (de) | 1994-04-07 |
EP0376607A1 (fr) | 1990-07-04 |
PT92728B (pt) | 1995-12-29 |
US5002948A (en) | 1991-03-26 |
DK645689A (da) | 1990-06-29 |
IE893976L (en) | 1990-06-13 |
EP0376607B1 (fr) | 1994-03-02 |
NO174772B (no) | 1994-03-28 |
DE68913487T2 (de) | 1994-08-04 |
AU637991B2 (en) | 1993-06-17 |
IL92990A (en) | 1995-01-24 |
ATE102184T1 (de) | 1994-03-15 |
GB8830312D0 (en) | 1989-02-22 |
CA2006356C (fr) | 1999-09-14 |
AU4719889A (en) | 1990-07-05 |
NZ231855A (en) | 1992-02-25 |
NO895281D0 (no) | 1989-12-27 |
IL92990A0 (en) | 1990-09-17 |
FI93005B (fi) | 1994-10-31 |
PT92728A (pt) | 1990-06-29 |
IE62668B1 (en) | 1995-02-22 |
ES2062050T3 (es) | 1994-12-16 |
JPH02225460A (ja) | 1990-09-07 |
ZA899960B (en) | 1990-11-28 |
JP2895121B2 (ja) | 1999-05-24 |
DK645689D0 (da) | 1989-12-19 |
FI93005C (fi) | 1995-02-10 |
NO895281L (no) | 1990-06-29 |
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